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BLNK encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development.
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The pre-B-cell receptor (pre-BCR (show BCR Proteins)) signaling molecules BLNK, BTK (show BTK Proteins) and BANK1 (show BANK1 Proteins) were positively regulated by the ZFP521 gene, leading to enhancement of the pre-BCR (show BCR Proteins) signaling pathway.
Authors demonstrate leukemogenicity of PAX5 (show PAX5 Proteins)-PML (show PML Proteins) by introducing it into normal mouse pro-B cells; B-cell linker protein (Blnk) is repressed by PAX5 (show PAX5 Proteins)-PML (show PML Proteins) in leukemia cells; enforced expression of Blnk increases survival despite introduction of PAX5 (show PAX5 Proteins)-PML (show PML Proteins).
B-cell linker protein expression contributes to controlling allergic and autoimmune diseases by mediating IL-10 (show IL10 Proteins) production in regulatory B cells.
Tumor suppressor BLNK is a target of transcriptional activation by PU.1 and Spi-B (show SPIB Proteins) in the B cell lineage.
a novel negative feedback regulation of BCR (show BCR Proteins) signaling by HPK1 (show MAP4K1 Proteins)-mediated phosphorylation, ubiquitination, and subsequent degradation of the activated BLNK
CMTM7 (show CMTM7 Proteins) functions to link sIgM and BLNK in the plasma membrane.
Live cell imaging and co-immunoprecipitation experiments confirmed that both SLP65 and CIN85 (show SH3KBP1 Proteins) are both required for the onset and progression phases of B-cell antigen receptor signal transduction.
malignant transformation of Btk (show BTK Proteins)/Slp65 double-deficient pre-B cells is independent of deregulated V(D)J recombination activity.
Swip-1 (show WSB1 Proteins) provides a membrane scaffold that is required for the Syk (show SYK Proteins)-, SLP-65-, and PLCgamma2 (show PLCG2 Proteins)-dependent BCR (show BCR Proteins)-induced calcium flux.
malignant transformation of Slp65(-/-) pre-B cells involves disruption of the p19(Arf)-Mdm2-p53 tumor suppressor pathway
vesicular signaling scaffolds are required for B cell activation indicates that vesicles may deliver preassembled signaling cargo to sites of BCR (show BCR Proteins) activation.
early Ca(2 (show CA2 Proteins)+) fluxing provides feed-forward signal amplification by promoting anchoring of the PLCgamma2 (show PLCG2 Proteins) C2 domain to phospho-SLP65.
up-regulation of BLNK is associated with RUNX1 (show RUNX1 Proteins) mutations in cytogenetically normal acute myeloid leukemia (show BCL11A Proteins).
16 of the 34 childhood pre-B acute lymphoblastic leukaemia samples that were tested showed a complete loss or drastic reduction of SLP-65 expression
The BLNK protein is present in the majority of mediastinal B cell lymphomas.
In B cells SLP-65 exists in a 180 kDa complex as well as in monomeric form.
V(H) gene rearrangement represents a frequent feature in B-lymphoid malignancy, which can be attributed to SLP65 deficiency in many cases.
Syk (show SYK Proteins) is required to link phosphorylated SLP-65 to Ca(2 (show CA2 Proteins)+) mobilization.
Plasmacytoid dendritic cells express a signalosome consisting of Lyn (show LYN Proteins), Syk (show SYK Proteins), Btk (show BTK Proteins), Slp65 (Blnk) and PLCgamma2 (show PLCG2 Proteins). Triggering CD303 leads to tyrosine phosphorylation of Syk (show SYK Proteins), Slp65, PLCgamma2 (show PLCG2 Proteins) & cytoskeletal proteins.
This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene.
, B-cell linker protein
, b-cell linker protein-like
, B-cell adapter containing a SH2 domain protein
, B-cell adapter containing a Src homology 2 domain protein
, cytoplasmic adapter protein
, lymphocyte antigen 57
, src homology 2 domain-containing leukocyte protein of 65 kDa
, B cell adaptor containing SH2 domain
, B cell linker protein
, B-cell activation
, Src homology 2 domain-containing leukocyte protein of 65 kDa
, Src homology [SH2] domain-containing leukocyte protein of 65 kD
, B cell linker protein BLNK
, B-cell adapter SH2 domain-containing protein