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The protein encoded by BRAP was identified by its ability to bind to the nuclear localization signal of BRCA1 and other proteins. Additionally we are shipping BRAP Proteins (4) and BRAP Kits (3) and many more products for this protein.
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Human Polyclonal BRAP Primary Antibody for WB - ABIN1881119
Fulcher, Roth, Fatima, Alvisi, Jans: The BRCA-1 binding protein BRAP2 is a novel, negative regulator of nuclear import of viral proteins, dependent on phosphorylation flanking the nuclear localization signal. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010
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IMPACT data were consistent with increased risks of onset among BRCA1 and BRCA2 (show BRCA2 Antibodies) mutation carriers
Expression of BRAP is increased in esophageal squamous cell carcinoma samples compared with non-tumor esophageal tissues; increased expression correlates with reduced patient survival time and promotes metastasis of xenograft tumors in mice.
Together the results indicate for the first time that BRAP2 may play an important NRNI role in germ cells of the testis, with an additional, scaffold/structural role in mature spermatozoa.
BRAP gene may confer vulnerability for schizophrenia in Han Chinese population.
ectopic expression of BRAP2 inhibits nuclear localization of HMG20A (show HMG20A Antibodies) and NuMA1 (show NUMA1 Antibodies), and prevents nuclear envelope accumulation of SYNE2 (show SYNE2 Antibodies).
genetic association studies in population of Chinese Han young adults in Beijing: Data suggest that 2 SNPs in BRAP (rs11066001; rs3782886) are associated with decreased risk of metabolic syndrome in this population.
BAP1 (show RNF2 Antibodies) expression closely correlates with age, clinical stage, pathologic differentiation and histological type in colorectal cancer (CRC (show CALR Antibodies)). BAP1 (show RNF2 Antibodies) may serve as a novel prognostic biomarker for CRC (show CALR Antibodies).
Brap2 regulates temporal control of NF-kappaB (show NFKB1 Antibodies) localization mediated by inflammatory response.
The BRAP polymorphism may not play an important role in ischemic stroke in the Taiwanese population.
The dominant effect of prolonged USP15 (show USP15 Antibodies) depletion upon signal amplitude is due to a decrease in CRAF (show RAF1 Antibodies) levels while allowing for the possibility that USP15 (show USP15 Antibodies) may also function to dampen MAPK (show MAPK1 Antibodies) signaling through direct stabilization of BRAP.
A molecular complex composed of Nde1, Lis1 (show PAFAH1B1 Antibodies), and Brap regulates the dynamic MAPK (show MAPK1 Antibodies) signaling threshold in a spatially dependent fashion.
p21 (show D4S234E Antibodies) Ras/Imp regulate cytokine production and migration in CD4 (show CD4 Antibodies) T cells
The protein encoded by this gene was identified by its ability to bind to the nuclear localization signal of BRCA1 and other proteins. It is a cytoplasmic protein which may regulate nuclear targeting by retaining proteins with a nuclear localization signal in the cytoplasm.
BRCA1 associated protein
, BRCA1-associated protein
, BRCA1-associated protein-like
, brca1-associated protein
, RING finger protein 52
, galectin-2-binding protein
, impedes mitogenic signal propagation
, renal carcinoma antigen NY-REN-63