anti-Bone Marrow Stromal Cell Antigen 1 (BST1) Antibodies

Mouse (Murine) Bone Marrow Stromal Cell Antigen 1 (BST1) interaction partners

1. Results indicate a neuronal role for CD157 in addition to its known functions in the digestive and immune systems. Less abundant expression of CD157 in the adult brain raises questions about the common features associated with the late onset of Parkinson's disease. Because CD157 is expressed abundantly in the embryonic brain, it may be involved in the processes of neuronal development that relate to psychiatric disorders.

2. These results demonstrate for the first time that CD157 plays a role as a neuro-regulator and suggest a potential role in pre-motor symptoms in Parkinson's disease.

3. CD157 molecule displays two distinct domains in its extracellular component. The first is implicated in the enzymic activities of the molecule and the second features adhesion/signalling properties [review]

4. results suggest that the BST-1-catalyzed generation of extracellular cADPR, followed by the concentrative uptake of the cyclic nucleotide by HP, may be physiologically relevant in normal hemopoiesis

5. TNF but not RANK-L led to the sustained upregulation of both CD38 and CD157 as demonstrated by real-time PCR and flow cytometry

6. Two ADPR cyclase family members (CD38 and CD157) are present in renal preglomerular resistance arterioles, and CD38 participation in acute vascular responses to vasoconstrictors is important in renal microcirculation.

Human Bone Marrow Stromal Cell Antigen 1 (BST1) interaction partners

1. Comparative phylogenetics indicate that exon 1b is a genomic innovation acquired during primate evolution, pointing to the importance of alternative splicing for CD157 function.

2. SNPs rs28532698 and rs4301112 in CD157 are not significantly associated with childhood autism spectrum disorder or the severity of the disease in a Chinese Han population.

3. the rs4698412 variant of BST-1 may increase the Parkinson disease susceptibility. [META-ANALYSIS]

4. A ligand-receptor complex SCRG1/BST1 axis facilitate mesenchymal stem cells migration, preserve OCT4 and CD271 expression, self-renewal and osteogenic differentiation.

5. A pre-steady state and steady state kinetic analysis of the N-ribosyl hydrolase activity of hCD157.

6. Studies indicate that vertebrate ADP-ribosyl cyclases (ARCs) Bst1 and CD38 with common gene structure of invertebrate ARC, suggesting the origin to the ancestor of bilaterian animals.

7. Autism and with features of regression-previously acquired speech lost in the second year of life. The younger sister, who also had asthma, inherited a maternal deletion of 4p15.32 that results in a BST1-CD38 fusion transcript.

8. BST1 rs11724635 polymorphism can interact with well water drinking to increase the risk of Parkinson's disease in a Taiwanese population.

9. These findings indicate a central role of CD157 in cell-extracellular matrix interactions and make CD157 an attractive therapeutic target in inflammation and cancer.

10. These results demonstrate for the first time that CD157 plays a role as a neuro-regulator and suggest a potential role in pre-motor symptoms in Parkinson's disease.

11. The results of this study indicated that the SNCA and BST1 SNPs generally increase the risk of developing PD and that SNCA rs11931074 in particular is associated with a higher risk of parkinson disease with family history.

12. The results of this study showed that no causative mutation in the BST1 gene in patients with Parkinson's disease.

13. This study confirmed the associations of BST1 with parkinson disease susceptibility and fail to show significant associations of alzheimer disease genome-wide association study (GWAS) top hits with PD susceptibility in a Korean population.

14. BST1 SNPs rs11931532, rs12645693, & rs11724635 did not correlate with sporadic PD. The relationship of rs11724635 & sporadic PD had borderline significance. Smoking or caffeine intake did not correlate with SNP rs11724635 affecting sporadic PD.

15. Findings implicate CD157 in the progression of EOC to metastatic disease and suggest that CD157 may represent a valuable therapeutic target.

16. The SNPs investigated in the BST1, PARK15 and PARK9 genes associated with PD susceptibility are not associated with PD in the northern Han Chinese population.

17. Direct replication of single nucleotide polymorphisms (SNPs) within SNCA and BST1 confirmed these two genes to be associated with the Parkinson's Disease in the Netherlands.

18. The CD157-integrin partnership provides optimal adhesion and transmigration of human monocytes.

19. found converging evidence of association with Parkinson's disease on 12q24 (rs4964469, combined P = 2.4 x 10(-7)) and confirmed the association on 4p15/BST1 (rs4698412, combined P = 1.8 x 10(-6)), previously reported in Japanese data