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BMPR1B encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. Additionally we are shipping BMPR1B Kits (26) and BMPR1B Proteins (20) and many more products for this protein.
Showing 10 out of 197 products:
Human Polyclonal BMPR1B Primary Antibody for IHC (p), WB - ABIN388739
Kan, Liu, McGuire, Berger, Awatramani, Dymecki, Kessler: Dysregulation of local stem/progenitor cells as a common cellular mechanism for heterotopic ossification. in Stem cells (Dayton, Ohio) 2009
Show all 5 Pubmed References
Human Monoclonal BMPR1B Primary Antibody for FACS - ABIN4895799
Wang, He, Zhang, Shi, Dong, Pei, Zhu: A Selective Cell Population From Dermis Strengthens Bone Regeneration. in Stem cells translational medicine 2016
Show all 3 Pubmed References
Human Monoclonal BMPR1B Primary Antibody for CyTOF, FACS - ABIN4899243
Hegarty, Sullivan, OKeeffe: Endocytosis contributes to BMP2-induced Smad signalling and neuronal growth. in Neuroscience letters 2017
These results indicate a germ-cell-autonomous role for BMP signal transduction in germ-cell differentiation.
Study concludes that growth/differentiation factor-5 (GDF-5 (show GDF5 Antibodies)) protects hippocampal neurons against kainic acid-induced neurodegeneration by signaling through bone morphogenetic protein receptor type IB, suggesting a therapeutic potential for GDF-5 (show GDF5 Antibodies) in neurodegenerative diseases.
dermal BMPRIB+ cells possessed a similar osteogenic differentiation potential with BMSCs in a mouse model. Dermal BMPRIB+ subpopulations possessed low immunogenicity and immunosuppressive properties before and after osteogenic differentiation.
BMPR1B plays distinct roles from BMPR1A and ACVR1 in maintaining bone mass and transducing BMP signaling
This study demonistrated that BMP signaling has no major role in the development of excitatory and inhibitory synapses in the lateral superior olive.
Local administration of adenovirus expressing siRNA-targeting BMPR-IB may be a feasible and effective therapeutic candidate to treat or prevent wear debris-associated osteolysis.
Type Ib BMP receptors mediate the rate of commissural axon extension through inhibition of cofilin (show CFL1 Antibodies) activity
the BMP-2 (show BMP2 Antibodies)-BMPR-IB-ODAM (show ODAM Antibodies)-MAPK (show MAPK1 Antibodies) signaling cascade has important roles in ameloblast differentiation and enamel mineralization
Variation in BMPR1B is associated with dizygotic twinning.
signaling through BMPR1A (show BMPR1A Antibodies);B performs at least two roles in early respiratory development: first, it promotes tracheal formation through repression of Sox2 (show SOX2 Antibodies); and second, it restricts the site of lung bud initiation.
These studies support a role for a functional BMP signaling axis as a tumor suppressor pathway in the ovary, with BMPR1A (show BMPR1A Antibodies) and BMPR1B acting downstream of BMP ligands and upstream of BMP receptor (show BMPR1A Antibodies) SMADs.
Results identified the tumor-suppressive BMPR1B regulated by miR (show MLXIP Antibodies)-1274a in clear cell renal cell carcinoma (show MOK Antibodies).
We detected two BMPR1B mutations in two unrelated PRS families, suggesting that BMPR1B disruption is probably a cause of human PRS.
over-expression of CYP2J2 (show CYP2J2 Antibodies) in MDA-MB-468-derived breast cancer cells activates BMPR1B expression that may contribute to increased migration
BMPR1A and the ubiquitous isoform of BMPR1B differed in mode of translocation into the endoplasmic reticulum; and (ii) BMPR1A was N-glycosylated while BMPR1B was not, resulting in greater efficiency of processing and plasma membrane expression of BMPR1A.
Mutations in three genes (GDF5 (show GDF5 Antibodies), NPR2 (show NPRL2 Antibodies), BMPR1B) have been reported to cause different forms of acromesomelic dysplasia
Data show that protein kinase (show CDK7 Antibodies) LKB1 (show STK11 Antibodies) physically interacts with BMP type I receptors and requires Smad7 (show SMAD7 Antibodies) protein to promote downregulation of the receptor.
Results show an association between age-induced depletion of the ovarian reserve and BMPR1B receptor density and suggest that the dysregulation of BMP receptor (show BMPR1A Antibodies) signalling may inhibit the normal steroidogenic differentiation required for maturation in older patients.
Low expression of BMPRIB is associated with breast cancer.
Two novel mutations in BMPR1B were identified in two patients with brachydactyly type A1.
Using computational analyses with the COREX/BEST algorithm, the study uncovered an overall pattern connecting various regions of BMPR-1B ectodomain, including the four conserved residues in the protein-protein interface.
These findings provide an important role of BMPRIB in the regulation of apoptosis and steroidogenesis of porcine granulosa cells.
Report temporal regulation of BMPR1B mRNA expression in the oocyte, granulosa and theca cells of developing preovulatory follicles in the pig.
Polymorphisms within the BMPR1B gene are associated with reproductive performance.
This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. Several transcript variants encoding two different isoforms have been found for this gene.
BMP receptor IB
, activin receptor-like kinase 6
, bone morphogenetic protein receptor type-1B
, bone morphogenetic protein receptor, type IB
, bone morphogenetic protein receptor type IB,b
, bone morphogenetic protein receptor type-1B-like
, BMP type-1B receptor
, serine/threonine-protein kinase receptor R6
, bone morphogenetic protein receptor, type 1b
, serine/threonine receptor kinase
, bone morphogenetic protein receptor IB
, bone morphogenetic protein binding serine/threonine kinase receptor
, receptor protein kinase
, bone morphogenetic protein receptor 1B