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CLEC4A encodes a member of the C-type lectin\\/C-type lectin-like domain (CTL\\/CTLD) superfamily. Additionally we are shipping C-Type Lectin Domain Family 4, Member A Antibodies (71) and C-Type Lectin Domain Family 4, Member A Proteins (6) and many more products for this protein.
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DCIR SNP rs2377422 is a novel genetic susceptibility factor for both SLE and primary SS.
this study shows that sulfo-Lewis(a) is a high affinity ligand for DCIR and that DCIR interacts with ligands from both pathogenic and endogenous origin of which most are shared by DC-SIGN (show CD209 ELISA Kits).
No association was found between our inflammatory bowel disease cohort and the candidate single nucleotide polymorphisms for DCIR (CD/HC: P=0.22 and UC/HC: P=0.41)
Data provide evidence for association between DCIR rs2377422 and RA in non-Caucasian populations and confirm the influence of DCIR polymorphisms on RA susceptibility, especially on ACPA (show PRTN3 ELISA Kits)-negative RA.
An involvement of ITIM domain in HIV-1-mediated signaling events and a relationship between phosphorylation events and DCIR function with respect to HIV-1 biology.
Data show that antigen targeting via the DCIR receptor allows activation of specific CD8 (show CD8A ELISA Kits)(+) T-cell immunity.
CLECSF6 is involved in the control of inflammation in neutrophils
The phosphorylation of SHP-2 (show PTPN11 ELISA Kits) by GM-CSF (show CSF2 ELISA Kits) promotes the binding of SHP-2 (show PTPN11 ELISA Kits) to the GM-CSF (show CSF2 ELISA Kits) receptor to the disadvantage of CLECSF6.
Human APLEC and DCIR may be associated with susceptibility to anti-CCP (show CRYGD ELISA Kits)-negative rheumatoid arthritis.
The data show that targeting of DCIR can modulate human plasmacytoid dendritic cell function and may be applied in disease prevention and treatment.
DCIR modulates immunity to M. tuberculosis through sustaining type I IFN signaling in DCs, which reduces IL-12 (show IL12A ELISA Kits)-p70 (show ANXA6 ELISA Kits) production and Th1 (show HAND1 ELISA Kits) expansion. As a consequence, DCIR-deficient mice control M. tuberculosis infection better than their WT counterparts but also develop more immunopathology in the lungs.
this study shows that upon injection of d-galactosamine and lipopolysaccharide, Dcir1-/- mice show decreased mortality rates and serum levels of alanine aminotransferase (show ALT ELISA Kits)
Dcir1 enhances the pathogenesis of DSS (show PMP22 ELISA Kits) colitis by altering neutrophil recruitment and their functions.
While DCIR1 was ubiquitously expressed on myeloid cells in various immune organs, significant expression of DCAR2 was detected only on subpopulations of conventional dendritic cells from bone marrow and skin-draining lymph nodes.
MCL (show CLEC4D ELISA Kits)-/- as well as DCIR-/- mice exhibited only a slightly increased severity of disease compared to wild-type mice indicating a limited role for MCL (show CLEC4D ELISA Kits) and DCIR in the regulation of intestinal immunity.
our findings show that DCIR plays an important role in maintaining bone homeostasis.
DCIR is a novel receptor for IVIg, mediating interaction of innate and adaptive immunity in tolerogenic responses.
This study indicates that DCIR is critically involved in Cerebral malaria induction
These results suggest that DCIR plays a protective role in limiting the Chikungunya virus-induced inflammatory response and subsequent tissue and joint damage.
These observations indicate that Dcir is a negative regulator of dendritic cell expansion and has a crucial role in maintaining the homeostasis of the immune system.
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in inflammatory and immune response. Multiple transcript variants encoding distinct isoforms have been identified for this gene. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.
C-type lectin domain family 4, member A
, C-type lectin, superfamily member 6
, C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 6
, C-type lectin DDB27
, C-type lectin domain family 4 member A
, C-type lectin superfamily member 6
, dendritic cell immunoreceptor
, lectin-like immunoreceptor
, C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 6
, dendritic cell inhibitory receptor 1