C-Type Natriuretic Peptide (NPPC) ELISA Kits

Mouse (Murine) C-Type Natriuretic Peptide (NPPC) interaction partners

1. in ovarian follicles, following the luteinizing hormone surge, NPPC levels increase initially and then decline rapidly

2. In cultured interstitial aortic valve cells, CNP inhibited pathological differentiation via the guanylate cyclase NPR2 and not natriuretic peptide receptor 3. CNP/NPR2 signaling is a novel regulator of aortic valve development and disease.

3. elevated in ovaries of polycystic ovary syndrome model

4. the overexpression CNP in endothelial cells promoted BAT thermogenesis, leading to increased energy expenditure and decreased MesWAT adipocyte hypertrophy, fatty liver, insulin resistance, and inflammation in HFD-fed Tg mice.

5. the present study indicates that CNP and its cognate receptor NPR2 mainly expressed in neurons represent an innate neuroprotective mechanism in neonataI hypoxia-ischemia brain injury.

6. this study shows that Nppc induces sperm attraction for fertilization

7. E2-ERs system was functional in maintaining oocyte meiotic arrest by regulating the expression of natriuretic peptide C and natriuretic peptide receptor 2 (NPPC/NPR2)

8. CNP activates bone turnover and remodeling in vivo and possibly accelerates fracture healing in a mouse model.

9. The up-to-day world-wide data about the structure, distribution, and physiological effects of the most poorly known among the natriuretic peptides--the C-type (CNP)--are summarized in the review.

10. Connexin mimetics directed against connexin-43 (Cx43 CMP) overcame NPPC-mediated meiotic arrest in both isolated cumulus oocyte complexes and antral follicles.

11. CNP/NPR-C pathway has potential as a disease-modifying therapeutic target for cardiovascular disorders

12. Data indicate an important, previously neglected, role of NEP for regulation of luminal factors in the epididymis and suggest a novel role for CNP/guanylyl cyclase B in the epididymal epithelium

13. CNP overexpression in chondrocytes can prevent endochondral growth delay and protect against cartilage damage in a mouse model of inflammatory arthritis.

14. Data suggest that intracerebroventricular administration of C-type natriuretic peptide (CNP-22 or CNP-53) has anorexigenic effect on hypothalamic neurons via activation of melanocortin/melanocortin receptor signal transduction.

15. CNP/NPR2 signaling is essential for oocyte meiotic arrest in early antral follicles and activated LH/amphiregulin/EGFR signaling pathway suppresses this signal by downregulating Nppc expression.

16. we show that CNP plays important region-specific roles in the GI tract of mice.

17. CNP secreted by growing follicles is capable of stimulating preantral and antral follicle growth

18. NPPC/NPR2 signaling is essential for oocyte meiotic arrest and cumulus oophorus formation, which affects female fertility through the production of oocytes with developmental capacity.

19. GTP-binding protein betagamma subunit-dependent potentiation of TRPV1 as novel signaling cascades recruited by CNP in dorsal root ganglia neurons leads to enhanced nociceptor excitability and thermal hypersensitivity and increases neuronal firing frequency.

20. These results demonstrate that lbab/lbab is a novel mouse model of chondrodysplasia caused by insufficient CNP action on endochondral ossification.

Human C-Type Natriuretic Peptide (NPPC) interaction partners

1. C-type natriuretic peptide may dampen FGF-23 expression via MAPK signaling pathway in mesangial cells

2. receptor signaling and NEP are involved in the resistance of CNP to human mesangial proliferation and Col-IV expression.

3. This review will focus on the novel physiological functions ascribed to CNP, the receptors/signalling mechanisms involved in mediating its cardioprotective effects, and the development of therapeutics targeting CNP signalling pathways in different disease pathologies.

4. Community elderly adults with myocardial ageing have lower NTproCNP levels compared to those with preserved myocardial function. Given that impaired myocardial relaxation probably represents early changes within the myocardium with ageing, NTproCNP may be useful as an 'upstream' biomarker useful for charting myocardial ageing

5. A link was found between circulating C-type natriuretic peptide and autonomic dysfunction in chronic kidney disease patients.

6. The Post-ictal serum NT-pro CNP levels were lower in epileptic seizures compared to psychogenic non-epileptic seizures as well as healthy controls.

7. two heterozygous NPPC mutations, located in the highly conserved ring, were identified; mutations cause autosomal dominant short stature in humans

8. This study showed that Plasma concentrations of amino-terminal proCNP are depressed in Parkinson's Disease.

9. C-type natriuretic peptide (CNP)administration significantly decreased the secretion and expression of MMP-2 and MMP-9 in the cultured mesangial cells ; (2) the secretion and expression of TIMP-1 progressively elevated after treatment with CNP for 24 and 48 h, whereas declined at later time point; (3) CNP expression was negatively correlated with MMP-2 and MMP-9 expression.

10. CNP level in pericardial fluid is a more sensitive marker of LV dysfunction than CNP levels in plasma in coronary artery disease patients undergoing coronary artery bypass grafting.

11. Data suggest mutations in NPR2 in patients with skeletal overgrowth alter conformation: A488P/R655C missense mutations yield conformation mimicking allosterically activated NPR2; A488P mutation sets phosphorylation as requirement for CNP-dependent activation; R655C mutation abrogates need for phosphorylation; ATP analog inhibits mutants. (NPR2 = atrial natriuretic factor receptor B; CNP = C-type natriuretic peptide)

12. CNP may play a more important role than BNP and ANP related peptides, as risk marker of obesity

13. CNP and FGF-23 act through a close or reciprocal pathway and are in agreement with recent studies demonstrating a down-regulatory role of the mitogen-activated protein kinase activity by CNP

14. CNP/NPR-B can affect sperm motility and acrosome reaction, thus regulating the reproductive function of males

15. CNP levels rose after paroxysmal supraventricular tachycardia and continued to rise after the termination.

16. examined whether CNP reduces hyaluronan production and export via members of the multidrug resistance protein (MRP) and diminishes pro-inflammatory effects in chondrocytes

17. Plasma CNP might serve as a useful predictor for the therapeutic efficacy of metoprolol on postural tachycardia syndrome in children.

18. CNP/proCNP could be new markers in human prostate cancer

19. This case supports the concept that NPPC is overexpressed because of the loss of a specific negative regulatory control in the normal chromosomal location, and demonstrates the effectiveness of targeted resequencing in the mapping of breakpoints.

20. An increased level of NT-pro CNP is a promising non-invasive marker of hepatitis C related CLD complications and disease progression.