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The protein encoded by CNOT4 is a subunit of the CCR4-NOT complex, a global transcriptional regulator. Additionally we are shipping CNOT4 Antibodies (136) and CNOT4 Proteins (4) and many more products for this protein.
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These results indicate that CNOT4 is a ubiquitin ligase of influenza A virus nucleoprotein, and ubiquitination of the nucleoprotein plays a positive role in viral RNA replication.
CNOT4 controls the degradation of chromatin-unbound PAF1 (show PEX2 ELISA Kits) via the 26S proteasome (show Psmd4 ELISA Kits).
Single nucleotide polymorphism in CNOT4 gene is associated with osteosarcoma susceptibility.
Data show that Not4/CNOT4 is a novel positive regulator of the JAK (show JAK3 ELISA Kits)/STAT (show STAT1 ELISA Kits) pathway in Drosophila and in humans.
Data show that binding of the CNOT4 RING finger to the ubiquitin-conjugating enzyme (E2) UbcH5B is highly selective
Data show that Ccr4-Not function in RNA splicing and nuclear export, and that CNOT4 binds CNOT1 in yeast two-hybrid assays.
The protein encoded by this gene is a subunit of the CCR4-NOT complex, a global transcriptional regulator. The encoded protein interacts with CNOT1 and has E3 ubiquitin ligase activity. Several transcript variants encoding different isoforms have been found for this gene.
CCR4-NOT transcription complex, subunit 4
, CCR4-NOT transcription complex subunit 4
, CCR4-associated factor 4
, E3 ubiquitin-protein ligase CNOT4
, NOT4 (negative regulator of transcription 4, yeast) homolog
, potential transcriptional repressor NOT4Hp
, negative regulator of transcription 4
, transcriptional repressor NOT4Hp
, uncharacterized protein LOC394144