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The protein encoded by CD163 is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. Additionally we are shipping CD163 Antibodies (426) and CD163 Proteins (15) and many more products for this protein.
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Human CD163 ELISA Kit for Sandwich ELISA - ABIN1979418
Wang, Yu, Yang, Wu, Zhu, Liu, Liu, Hu, Wu, Xia, Chen: Expression of serum sCD163 in patients with liver diseases and inflammatory disorders. in International journal of clinical and experimental pathology 2015
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Mouse (Murine) CD163 ELISA Kit for Sandwich ELISA - ABIN425050
Mukai, Komatsu, Nakajima, Urai, Nasruddin, Sugama, Nakatani: The effect of 17?-estradiol on cutaneous wound healing in protein-malnourished ovariectomized female mouse model. in PLoS ONE 2014
Human CD163 ELISA Kit for Sandwich ELISA - ABIN578184
Hedegaard, Sellebjerg, Krakauer, Hesse, Bendtzen, Nielsen: Interferon-beta increases systemic BAFF levels in multiple sclerosis without increasing autoantibody production. in Multiple sclerosis (Houndmills, Basingstoke, England) 2011
house dust mite -challenged Cd163-/- mice displayed increases in airway eosinophils and mucous cell metaplasia
In diabetic mice, increased sCD163 at wk 5 and decreased percentage of CD163(+) monocytes at wk 10 preceded alteration in kidney collagen IV mRNA at wk 20. In vitro incubation of monocytes in anti-inflammatory glucocorticoid increased the percentage of CD163(+) monocytes.
During ischaemia, soluble CD163 functions as a decoy receptor for TWEAK (show TNFSF12 ELISA Kits), to regulate TWEAK (show TNFSF12 ELISA Kits)-induced activation of canonical nuclear factor-kappaB and Notch (show NOTCH1 ELISA Kits) signalling necessary for myogenic progenitor cell proliferation.
Data indicate an essential substrate motif for ADAM17 (show ADAM17 ELISA Kits)-mediated CD163 and proTNF-alpha cleavage in macrophages.
alpha(1)-Acid glycoprotein (show ORM1 ELISA Kits) up-regulates CD163 via TLR4 (show TLR4 ELISA Kits)/CD14 protein (show ERGIC2 ELISA Kits) pathway: possible protection against hemolysis-induced oxidative stress.
Data show that telmisartan reduced the mRNA expression of CD11c (show ITGAX ELISA Kits) and TNF-alpha (show TNF ELISA Kits), M1 macrophage markers, and significantly increased the expressions of M2 markers, such as CD163, CD209 (show CD209 ELISA Kits).
Assignment of the CD163 antigen to mouse chromosome 6 band F2.
Although sCD163 level cannot predict the development of varices, it serves as a good predictor for the detection of size of varices (large varices), the need of prophylactic interventions, and risk of variceal bleeding. sCD163 level is a helpful indicator with the progression of cirrhosis and portal hypertension.
CD163 and ferritin (show FTL ELISA Kits) are biomarkers of functional outcomes in intracerebral hemorrhage.
the simultaneous detection of both plasma sCD14 and IL-6 (show IL6 ELISA Kits) is a promising diagnostic approach to identify active pulmonary tuberculosis, and further, measurement of TNF-alpha (show TNF ELISA Kits) and sCD163 can identify the most severe cases of tuberculosis.
The macrophage activation marker CD163 was increased in patients with active pulmonary TB compared with age- and sex-matched control subjects.
alveolar macrophages from asthmatic subjects have reduced cell-surface expression of CD163, which suggests that CD163 might modulate the pathogenesis of asthma
Serum sCD163 might be a potential biomarker for predicting the severity and prognosis of PM/DM-related interstitial lung disease
Soluble CD163 reflecting macrophage activation is associated with morphological features of non-alcoholic fatty liver disease. An independent association between sCD163 and cytokeratin-18 (show KRT18 ELISA Kits) suggests that apoptosis may contribute to macrophage activation in NAFLD (show TSC2 ELISA Kits)/NASH (show SAMSN1 ELISA Kits).
Most cases of histiocytic sarcoma expressed histiocytic markers CD68 (show CD68 ELISA Kits) (6 of 7 cases), CD163 (5 of 5 cases), and PU.1 (3 of 4 cases).
Within a diabetic cohort, the percentage of monocytes expressing CD163 was decreased in those subjects with complications, compared to those without complications. These changes were not accompanied by a change in gene expression. Glucocorticoids increased CD163 expression in cultured peripheral blood monocytes from non-diabetic persons.
sCD163 was markedly elevated in autoimmune hepatitis (AIH) in the acute phase, normalised by successful treatment in complete responders, but remained higher in the incompletely responding cases. Our results demonstrate macrophage activation in AIH paralleling disease activity, severity and treatment response, suggesting a role for macrophage activation in AIH.
deletion of Exon 7 of the CD163 gene, encoding SRCR5 had no adverse effects in pigs and these animals showed complete resistance to viral infection by the positive-strand RNA PRRS virus
CD163 is not necessary for infection with African swine fever virus.
CD163 represents an additional candidate gene for resistance against porcine reproductive and respiratory syndrome.
Overexpression of ADAM17 (show ADAM17 ELISA Kits) induced downregulation of CD163 expression and a reduction in reproductive and respiratory syndrome virus infection.
Fusion protein of sialoadhesin (show SIGLEC1 ELISA Kits) and domains 5-9 of CD163 receptors blocked the respiratory syndrome virus infection.
GP4 (show CD36 ELISA Kits) is involved in interaction with cellular receptor CD163.
). These results provided fundamental evidence for CD163 and SN as two functional candidate genes affecting immunity in pigs.
Porcine reproductive and respiratory syndrome virus GP4 (show CD36 ELISA Kits) was found to co-localize with CD163 in the lipid rafts on the plasma membrane.
Our results suggest that the intracellular domain of CD163 may be associated with an important yet-unknown function during porcine reproductive and respiratory syndrome virus replication.
The newly established porcine alveolar macrophage cell lines were demonstrated to express robust levels of CD163 and to be fully permissive for both type 1 and 2 porcine reproductive and respiratory syndrome virus strains.
The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
, CD163 molecule
, scavenger receptor cysteine-rich type 1 protein M130-like
, scavenger receptor cysteine-rich type 1 protein M130
, hemoglobin scavenger receptor
, macrophage-associated antigen