anti-CD33 Molecule (CD33) Antibodies

Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Additionally we are shipping CD33 Proteins (32) and CD33 Kits (21) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CD33 945 P20138
CD33 12489 Q63994
CD33 690492  
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Top anti-CD33 Antibodies at antibodies-online.com

Showing 10 out of 527 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Mouse Rabbit Un-conjugated FACS, IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human gastric carcinoma labeled with Rabbit Anti CD33/Siglec-3 Polyclonal Antibody, Unconjugated at 1:200 followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin-embedded mouse intestine labeled with Anti-CD33/Siglec-3 Polyclonal Antibody, Unconjugated (ABIN687607) 1:200, overnight at 4°C, The secondary antibody was Goat Anti-Rabbit IgG, Cy3 conjugated used at 1:200 dilution for 40 minutes at 37°C. 100 μL 3 to 7 Days
$339.90
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-CD33 Antibody Titration: 1.0 ug/ml Positive Control: Fetal Heart 100 μL 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated FACS, IHC, ELISA, WB 0.1 mg 3 to 4 Days
$430.10
Details
Human Mouse PerCP FACS, Func, ICC, IHC (f), IP, MCA, WB Surface staining of human peripheral blood with anti-CD33 (WM53) PerCP. 100 Tests 5 to 7 Days
$484.24
Details
Human Mouse APC FACS, Func, ICC, IHC (f), IP, MCA, WB Surface staining of human peripheral blood with anti-CD33 (WM53) APC. 100 Tests 5 to 7 Days
$484.24
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB CD33 was detected in paraffin-embedded sections of human tonsil tissues using rabbit anti- CD33 Antigen Affinity purified polyclonal antibody (Catalog # ) at 1 µg/mL. The immunohistochemical section was developed using SABC method (Catalog # SA1022). Flow Cytometry analysis of U937 cells using anti-CD33 antibody . Overlay histogram showing U937 cells stained with  (Blue line).The cells were blocked with 10% normal goat serum. And then incubated with rabbit anti-CD33 Antibody (,1µg/1x106 cells) for 30 min at 20°C. DyLight?488 conjugated goat anti-rabbit IgG (BA1127, 5-10µg/1x106 cells) was used as secondary antibody for 30 minutes at 20°C. Isotype control antibody (Green line) was rabbit IgG (1µg/1x106) used under the same conditions. Unlabelled sample (Red line) was also used as a control. 100 μg 4 to 6 Days
$280.00
Details
Mouse Rabbit Un-conjugated IHC (p), WB CD33 was detected in paraffin-embedded sections of mouse pleen tissues using rabbit anti- CD33 Antigen Affinity purified polyclonal antibody (Catalog # ) at 1 ??g/mL. The immunohistochemical section was developed using SABC method (Catalog # SA1022). Western blot analysis of CD33 expression in mosue lung extract ( Lane 1). CD33 at 45KD was detected using rabbit anti-CD33 Antigen Affinity purified polyclonal antibody (Catalog # ) at 0.5 µg/mL. The blot was developed using chemiluminescence (ECL) method (Catalog # EK1002). 100 μg 4 to 6 Days
$280.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL 6 to 8 Days
$522.50
Details
Human Mouse Un-conjugated FACS, Func, ICC, IHC (f), IP, MCA, WB Surface staining of human peripheral blood with anti-CD33 (WM53) purified, GAM-APC. 0.1 mg 5 to 7 Days
$333.96
Details
Human Rabbit Un-conjugated WB Western blot analysis of CD33 expression in HepG2 (A), KB (B), NIH3T3 (C) whole cell lysates. 200 μL 13 to 14 Days
$487.50
Details

Top referenced anti-CD33 Antibodies

  1. Human Monoclonal CD33 Primary Antibody for FACS, Func - ABIN1302947 : Garnache-Ottou, Chaperot, Biichle, Ferrand, Remy-Martin, Deconinck, de Tailly, Bulabois, Poulet, Kuhlein, Jacob, Salaun, Arock, Drenou, Schillinger, Seilles, Tiberghien, Bensa, Plumas, Saas: Expression of the myeloid-associated marker CD33 is not an exclusive factor for leukemic plasmacytoid dendritic cells. in Blood 2005 (PubMed)
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  2. Human Monoclonal CD33 Primary Antibody for FACS, Func - ABIN1303156 : Schenk, Bouchon, Birrer, Colonna, Mueller: Macrophages expressing triggering receptor expressed on myeloid cells-1 are underrepresented in the human intestine. in Journal of immunology (Baltimore, Md. : 1950) 2004 (PubMed)
    Show all 8 Pubmed References

  3. Human Monoclonal CD33 Primary Antibody for FACS, Func - ABIN1302526 : Leone, Rutella, Bonanno, Abbate, Rebuzzi, Giovannini, Lombardi, Galiuto, Liuzzo, Andreotti, Lanza, Contemi, Leone, Crea: Mobilization of bone marrow-derived stem cells after myocardial infarction and left ventricular function. in European heart journal 2005 (PubMed)
    Show all 8 Pubmed References

  4. Human Monoclonal CD33 Primary Antibody for FACS, Func - ABIN1302476 : Shin, Choi, Kim, Chung, Chung, Park, Jung, Kim, Park, Kim, Park, Min, Kim, Park: Expression of leukemia-associated antigen, JL1, in bone marrow and thymus. in The American journal of pathology 2001 (PubMed)
    Show all 8 Pubmed References

  5. Human Monoclonal CD33 Primary Antibody for FACS, Func - ABIN780369 : Vitale, Romagnani, Puccetti, Olive, Costello, Chiossone, Pitto, Bacigalupo, Moretta, Mingari: Surface expression and function of p75/AIRM-1 or CD33 in acute myeloid leukemias: engagement of CD33 induces apoptosis of leukemic cells. in Proceedings of the National Academy of Sciences of the United States of America 2001 (PubMed)
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  6. Human Monoclonal CD33 Primary Antibody for FACS, Func - ABIN775711 : Bradstock, Kirk, Grimsley, Kabral, Hughes: Unusual immunophenotypes in acute leukaemias: incidence and clinical correlations. in British journal of haematology 1989 (PubMed)
    Show all 8 Pubmed References

  7. Mouse (Murine) Polyclonal CD33 Primary Antibody for FACS, IF (p) - ABIN687607 : Shi, Jiang, Li, Shan, Li, An, Yang, Xu: Sodium selenite alters microtubule assembly and induces apoptosis in vitro and in vivo. in Journal of hematology & oncology 2013 (PubMed)
    Show all 5 Pubmed References

  8. Human Monoclonal CD33 Primary Antibody for FACS - ABIN2689195 : Favaloro, Moraitis, Koutts, Exner, Bradstock: Endothelial cells and normal circulating haemopoietic cells share a number of surface antigens. in Thrombosis and haemostasis 1989 (PubMed)
    Show all 3 Pubmed References

  9. Human Monoclonal CD33 Primary Antibody for FACS - ABIN2689194 : Nakamura, Noma, Kidokoro, Kobayashi, Takei, Kurashima, Mukaiyama, Kato: Expression of CD33 antigen on normal human activated T lymphocytes. in Blood 1994 (PubMed)
    Show all 3 Pubmed References

  10. Human Polyclonal CD33 Primary Antibody for IHC (p), ELISA - ABIN544590 : Yousef, Ordon, Foussias, Diamandis: Genomic organization of the siglec gene locus on chromosome 19q13.4 and cloning of two new siglec pseudogenes. in Gene 2002 (PubMed)
    Show all 3 Pubmed References

More Antibodies against CD33 Interaction Partners

Human CD33 Molecule (CD33) interaction partners

  1. CD33 expression of monocytes in human blood samples processed at different temperatures and in dependence on their phagocytic activity against opsonized Escherichia coli

  2. In normal hematopoiesis by CRISPR/Cas9-deletion of CD33 exon 2.

  3. A potent CD3/CD33 bispecific FynomAb.

  4. Identify a subset of cord blood cells with CD33(+)CD34(+)CD38(-)CD45RA(-)CD90(+)CD49f(+) phenotype which are serially transplantable, but have diverse cell output profiles.

  5. Data show that the intensity level of CD33 protein (CD33) on the monocytes is directly related to the rs12459419 single nucleotide polymorphism (SNP) genotypes CC, CT and TT.

  6. These findings demonstrate that C1q and it's globular region interact with CD33 to activate its inhibitory motifs, while the collagen-like region does not. Whole C1q is required to crosslink CD33 and LAIR-1 and concurrently activate CD33/LAIR-1 inhibitory motifs.

  7. rs3865444 CD33 acts as a protective factor against late-onset Alzheimer's disease.

  8. Genetic variations in CD33 influence atrophy of specific Alzheimer's Disease-related brain structures; specifically the hippocampus and parahippocampal gyrus.

  9. The mean percentage of CD33-positivity of the myeloblast population was 80.5% in acute myeloid leukemia (AML), 81.8% in chronic myelomonocytic leukemia (CMML) and 75% in myelodysplastic syndromes (MDS).

  10. The 161533 TriKE induced superior NK cell cytotoxicity, degranulation, and cytokine production against CD33(+) HL-60 targets and increased NK survival and proliferation.

  11. High efficacy of CD33/CD3 TandAbs in various preclinical models of human AML.

  12. The use of CD33(+)CD11b(+)HLA-DR(-) cells as a predictive and prognostic biomarker.

  13. Data suggest that two SNPs in CD33 (rs3865444A, rs12459419T) that are protective of Alzheimer disease result in splice variants (CD33M, CD33m); CD33M localizes predominantly at cell surface in macrophage cell line; CD33m is primary intracellular form in neutrophils and a microglia cell line; intracellular CD33m accumulates in peroxisomes; activation of macrophages/neutrophils does not mobilize CD33m to cell surface.

  14. In cutaneous diffuse large b-cell lymphoma, a considerable proportion of CD33(+) myeloid-derived suppressor cells (MDSCs) with PD-L1 coexpression was admixed. Tumor cells expressed CD33 to variable degrees (2% to 60%). We propose that PD-L1(+) tumor cells and PD-L1(+) MDSCs shield the tumor against PD-1(+) tumor-infiltrating lymphocytes, consequently leading to inhibition and diminution of tumor-infiltrating lymphocytes.

  15. patients with the CC genotype for rs12459419 have a substantial response to Gemtuzumab Ozogamicin, making this a potential biomarker for the selection of patients with a likelihood of significant response to Gemtuzumab Ozogamicin.

  16. CD33-expressing microglia play a central role in the development of leukoencephalopathy in Nasu-Hakola disease brains

  17. There is substantial evidence that rs3865444 (CD33) function is related to AD pathways and pathology, but our data does not support an interaction with rs670139 (MS4A4E) that impacts AD risk.

  18. this study investigated the contribution of the immunoregulatory receptor CD33 to a uniquely human postreproductive disease, Alzheimer's dementia.

  19. the CD33 rs3865444 polymorphism is associated with Alzheimer's disease susceptibility in Chinese, European, and North American populations.

  20. CD33 and MS4A cluster variants are associated with LOAD susceptibility in East Asian populations.

Mouse (Murine) CD33 Molecule (CD33) interaction partners

  1. Lectin galactoside-binding soluble 3 binding protein (LGALS3BP) is a tumor-associated immunomodulatory ligand for CD33-related Siglecs.

  2. CD33-related Siglec-E recognizes the intact neuron and has neuroprotective function by preventing phagocytosis.

  3. mCD33 is expressed on myeloid precursors in the bone marrow

  4. SOCS3 inhibited the CD33-induced block on cytokine-induced proliferation. SOCS3 and its target protein CD33 are degraded concomitantly concomitantly.

CD33 Antigen Profile

Protein Summary

Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro).

Gene names and symbols associated with anti-CD33 Molecule (CD33) Antibodies

  • CD33 molecule (CD33) antibody
  • CD33 antigen (Cd33) antibody
  • CD33 molecule (Cd33) antibody
  • gp67 antibody
  • p67 antibody
  • Siglec-3 antibody
  • SIGLEC3 antibody

Protein level used designations for anti-CD33 Molecule (CD33) Antibodies

CD33 antigen (gp67) , gp67 , myeloid cell surface antigen CD33 , sialic acid binding Ig-like lectin 3 , sialic acid-binding Ig-like lectin 3

GENE ID SPECIES
945 Homo sapiens
456242 Pan troglodytes
12489 Mus musculus
690492 Rattus norvegicus
102117580 Macaca fascicularis
719855 Macaca mulatta
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