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Isoform 2 has been described as a component of preformed T-cell receptor (TCR) complex. Additionally we are shipping CD3e Molecule, epsilon Associated Protein Antibodies (85) and many more products for this protein.
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yeast A34.5/A49 and mammalian PAF49/PAF53 heterodimeric complexes interact through species-specific sequence elements that appear to assume similar structural motifs.
These results strongly suggest that RNA polymerase I (Pol I)-associated factor PAF49/ASE-1 plays an important role in rRNA transcription.
Serial deletion analysis revealed that amino acids 199-338 were necessary for the nucleolar localization of PAF49.
Haplotypes consisting of PPP1R13L, CD3EAP and GLTSCR1 SNPs on Chr19q13.3 may associate with lung cancer risk in the Chinese population.
The expression of CD3EAP exon 1 was demonstrated to be significantly associated with PPP1R13L exon 1, while CD3EAP exon 3 was significantly associated with ERCC1 exon 11 in normal and non-small cell lung cancer (NSCLC) tissues. It was observed that short transcripts of ERCC1, CD3EAP and PPP1R13L are co-expressed in A549 NSCLC cell line.
a genetic variant in the CD3EAP gene is associated with outcome of patients treated for multiple myeloma
These findings demonstrate that 19p13.3-GADD45B rs7354 variant and interaction between 19p13.3-GADD45B rs3783501 and 19q13.3-CD3EAP rs967591 may play a role in association with smoke-exposed lung cancer among Chinese.
we were able to reproduce previously found associations between PPP1R13L and CD3EAP polymorphisms and lung cancer risk in an increased study group, and we found interactions between NFKB1 rs28362491-PPP1R13L rs1970764 and smoking duration and between CD3EAP rs735482 and smoking duration
There was no interaction between NFKB1 polymorphisms and PPP1R13L and CD3EAP and smoking status in relation to lung cancer risk
In nonsmoking Chinese women CD3EAP rs967591 variant allele carriers are at increased risk of lung cancer.
variant alleles of PPP1R13L rs1970764 and CD3EAP rs967591 may contribute to risk factors of lung cancer.
Polymorphism in RAI and CD3EAP are associated with outcome of myeloma patients treated with high dose treatment.
model for CAST/hPAF49 function in which the network of interactions of Pol I-specific subunits with UBF facilitates conformational changes of the polymerase, leading to stabilization of the Pol I-template complex and, thereby, activation of transcription
The ASE-1 polymorphism was associated with an increased risk of adenomas, OR of 1.39 (95% CI 1.06-1.81), which upon stratification was apparent among women only, OR of 1.66 (95% CI 1.15-2.39)
ASE-1 polymorphisms and the previously identified ASE-1 haplotype are not associated with risk of colorectal cancer.
A SNP in the 5' noncoding region of exon 1 at position -21 from the first codon, which does not affect the final AA sequence but may affect transcription/translation, was associated with drug sensitivity in the NC160 human cancer cell line panel.
ASE-1 co-localises with the RNA polymerase I transcription initiation factor UBF/NOR-90 throughout all stages of the cell cycle and these two proteins associate with each other in vitro.
Isoform 2 has been described as a component of preformed T-cell receptor (TCR) complex. DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Isoform 1 is involved in UBTF-activated transcription, presumably at a step following PIC formation.
CD3E antigen, epsilon polypeptide associated protein
, DNA-directed RNA polymerase I subunit RPA34
, CD3e molecule, epsilon associated protein
, DNA-directed RNA polymerase I subunit RPA34-like
, CD3 epsilon associated protein; antisense to Ercc1
, CD3-epsilon-associated protein
, CD3E-associated protein
, RNA polymerase I-associated factor PAF49
, anti-sense to ERCC-1 protein
, CD3 epsilon associated protein
, CD3e antigen, epsilon polypeptide associated protein
, antisense to ERCC 1
, antisense to ERCC-1 protein
, CD3E antigen, epsilon polypeptide-associated protein