anti-CD47 (CD47) Antibodies

CD47 encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. Additionally we are shipping CD47 Proteins (62) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CD47 16423 Q61735
CD47 961 Q08722
CD47 29364 P97829
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Top anti-CD47 Antibodies at antibodies-online.com

Showing 10 out of 357 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Sheep Un-conjugated CyTOF, FACS, IHC, Neut, WB 100 μg Log in to see 8 to 9 Days
$416.30
Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC Immunohistochemistry: CD47 Antibody [NBP2-32031] - Ovarian cancer Immunohistochemistry: CD47 Antibody [NBP2-32031] - Prostate 0.1 mL Log in to see 7 to 9 Days
$491.63
Details
Human Rabbit Un-conjugated WB Western blot analysis of CD47 using anti-CD47 antibody . Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each  Lane was loaded with 50ug of sample under reducing conditions.  Lane 1: human MCF-7 whole cell lysates, Lane 2: human SK-OV-3 whole cell lysates, Lane 3: human PANC-1 whole cell lysates. After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-CD47 antigen affinity purified polyclonal antibody (Catalog # ) at 0.5 ug/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for CD47 at approximately 41KD. The expected band size for CD47 is at 35KD. 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Mouse APC FACS Detection of CD47 in Human Blood Lymphocytes by Flow Cytometry. Human peripheral blood lymphocytes were stained with Mouse Anti-Human CD47 APC-conjugated Monoclonal Antibody. 100 Tests Log in to see 8 to 9 Days
$351.90
Details
Human Mouse FITC FACS, IHC (f), WB Surface staining of lysed and washed porcine peripheral blood with purified anti-CD47 (MEM-122) (detection by anti-mouse IgM FITC). Panel A - porcine PBMC stained with Isotype mouse IgM control (PFR-03 Surface staining of human peripheral blood with anti-CD47 (MEM-122) FITC. 100 Tests Log in to see 5 to 7 Days
$316.25
Details
Human Mouse Un-conjugated FACS, IHC (f), WB Surface staining of lysed and washed porcine peripheral blood with purified anti-CD47 (MEM-122) (detection by anti-mouse IgM FITC). Panel A - porcine PBMC stained with Isotype mouse IgM control (PFR-03 0.1 mg Log in to see 5 to 7 Days
$265.65
Details
Human Rabbit Un-conjugated FACS, IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat tongue tissue labeled with Anti-CD47/MER6 Polyclonal Antibody, Unconjugated (ABIN739530) at 1:200 followed by conjugation to the secondary antibody Formalin-fixed and paraffin embedded rat tongue tissue labeled with Anti-CD47 MER6 Polyclonal Antibody, unconjugated  (ABIN739530)  at 1: 200  followed by incubation with conjugated secondary antibody 100 μL Log in to see 3 to 7 Days
$318.45
Details
Human Mouse Un-conjugated CyTOF, FACS, IHC, IHC (p), IP, WB Western Blot: CD47 Antibody (B6H12.2) [Azide Free] [NBP2-31106] - Human brain (lane 1) and testis (lane 2) protein was separated on a 12% gel by SDS-PAGE. Protein was transferred to PVDF membrane, blocked and then probed with 2 ug/ml of anti-CD47. CD47 protein was detected using an anti-mouse HRP secondary antibody. Immunohistochemistry-Paraffin: CD47 Antibody (B6H12.2) [Azide Free] [NBP2-31106] - IHC analysis of formalin-fixed paraffin-embedded tissue section of human normal breast using mouse monoclonal CD47 antibody (clone B6H12.2) at 0.5ug/ml concentration. The ductal/acinar epithelial cells in the breast section developed specific membrane-cytoplasmic staining. 0.1 mg Log in to see 7 to 9 Days
$556.31
Details
Mouse Rabbit Un-conjugated ICC, IHC, WB Figure. DAB staining on IHC-P; Samples: Mouse Stomach Tissue. 100 μg Log in to see 13 to 16 Days
$342.00
Details

Top referenced anti-CD47 Antibodies

  1. Mouse (Murine) Monoclonal CD47 Primary Antibody for FM, FACS - ABIN1177307 : Jiang, Lagenaur, Narayanan: Integrin-associated protein is a ligand for the P84 neural adhesion molecule. in The Journal of biological chemistry 1999 (PubMed)
    Show all 5 Pubmed References

  2. Rat (Rattus) Monoclonal CD47 Primary Antibody for FACS, IP - ABIN2480655 : Carlström: Viral infections and birth defects. in Acta obstetricia et gynecologica Scandinavica. Supplement 1977 (PubMed)
    Show all 4 Pubmed References

  3. Human Monoclonal CD47 Primary Antibody for FACS - ABIN1177375 : Brown, Hooper, Ho, Gresham: Integrin-associated protein: a 50-kD plasma membrane antigen physically and functionally associated with integrins. in The Journal of cell biology 1991 (PubMed)
    Show all 2 Pubmed References

  4. Human Monoclonal CD47 Primary Antibody for IHC (fro), FACS - ABIN2689294 : Gresham, Goodwin, Allen, Anderson, Brown: A novel member of the integrin receptor family mediates Arg-Gly-Asp-stimulated neutrophil phagocytosis. in The Journal of cell biology 1989 (PubMed)
    Show all 2 Pubmed References

  5. Human Polyclonal CD47 Primary Antibody for CyTOF, FACS - ABIN4899369 : Baccelli, Schneeweiss, Riethdorf, Stenzinger, Schillert, Vogel, Klein, Saini, Bäuerle, Wallwiener, Holland-Letz, Höfner, Sprick, Scharpff, Marmé, Sinn, Pantel, Weichert, Trumpp: Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay. in Nature biotechnology 2013 (PubMed)
    Show all 2 Pubmed References

  6. Human Polyclonal CD47 Primary Antibody for FACS, IF (p) - ABIN739530 : Miedel, Dishowitz, Myers, Dopkin, Yu, Miclau, Marcucio, Ahn, Hankenson: Disruption of thrombospondin-2 accelerates ischemic fracture healing. in Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2013 (PubMed)

  7. Human Monoclonal CD47 Primary Antibody for FACS, IHC (f) - ABIN94154 : Smith, Patel, Seatter, Deehan, Brown, Brooke, Goodridge, Howard, Rigley, Harnett, Harnett: A novel MyD-1 (SIRP-1alpha) signaling pathway that inhibits LPS-induced TNFalpha production by monocytes. in Blood 2003 (PubMed)
    Show all 4 Pubmed References

  8. Human Monoclonal CD47 Primary Antibody for FACS, IHC (f) - ABIN192129 : Isenberg, Pappan, Romeo, Abu-Asab, Tsokos, Wink, Frazier, Roberts: Blockade of thrombospondin-1-CD47 interactions prevents necrosis of full thickness skin grafts. in Annals of surgery 2007 (PubMed)
    Show all 4 Pubmed References

  9. Human Monoclonal CD47 Primary Antibody for FACS - ABIN4896002 : Albert, Veréb, Csomós, Moe, Johnsen, Olstad, Nicolaissen, Rajnavölgyi, Fésüs, Berta, Petrovski: Cultivation and characterization of cornea limbal epithelial stem cells on lens capsule in animal material-free medium. in PLoS ONE 2012 (PubMed)

  10. Human Monoclonal CD47 Primary Antibody for CyTOF, FACS - ABIN4261427 : Kojima, Volkmer, McKenna, Civelek, Lusis, Miller, Direnzo, Nanda, Ye, Connolly, Schadt, Quertermous, Betancur, Maegdefessel, Matic, Hedin, Weissman, Leeper: CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis. in Nature 2016 (PubMed)

More Antibodies against CD47 Interaction Partners

Mouse (Murine) CD47 interaction partners

  1. CD11c (show ITGAX Antibodies) and its partner Itgb2 (show ITGB2 Antibodies) were required for DC capture of CD47-deficient cells. CD11b (show ITGAM Antibodies) was not necessary for this process but could partially compensate in the absence of CD11c (show ITGAX Antibodies). Mice with DCs lacking Talin1, Itgb2 (show ITGB2 Antibodies), or CD11c (show ITGAX Antibodies) were defective in supporting T-cell proliferation and differentiation induced by CD47-deficient cell associated antigen.

  2. this study shows that inhibition of IAP (show ALPI Antibodies) represses inflammatory status via nuclear factor-kappa B pathway in murine endometriosis lesions

  3. Our results support an intrinsic role of CD47 in ovarian cancer progression and immune evasion

  4. Mechanistic studies suggest a PKC (show PKC Antibodies)-Syk (show SYK Antibodies)-mediated signaling pathway, to which IL-10 (show IL10 Antibodies) conversely inhibits, is required for activating macrophage self-targeting, followed by phagocytosis independent of calreticulin (show CALR Antibodies) Moreover, we identified spleen red pulp to be one specific tissue that provides stimuli constantly activating macrophage phagocytosis albeit lacking in Cd47(-/-) or Sirpalpha(-/-) mice.

  5. mice deficient in CD47 (CD47 Knockout) had significantly less brain neutrophil infiltration at 24h, upregulated VEGF (show VEGFA Antibodies) expression in peri (show POSTN Antibodies)-lesion cortex at 7 and 14day

  6. TSP1 (show GZMA Antibodies) significantly accelerates replicative senescence and associated cell cycle arrest in a CD47-dependent manner.

  7. CD47, TSP1 (show GZMA Antibodies), and to a lesser extent SIRPalpha facilitate exosome-mediated myeloid-derived suppressor cells chemotaxis and migration.

  8. In pulmonary hypertension TSP1 (show GZMA Antibodies)-CD47 is upregulated, and contributes to pulmonary arterial vasculopathy and dysfunction.

  9. thrombospondin-1 (show THBS1 Antibodies) via CD47 inhibits renal tubular epithelial cell recovery after ischemia reperfusion injury through inhibition of proliferation/self-renewal.

  10. these findings have demonstrated how tumor cells inhibit innate sensing in dendritic cells and suggested that the CD47-SIRPalpha axis is critical for dendritic cell-driven antitumor immunity

Human CD47 interaction partners

  1. High CD47 expression is associated with the increase in the ability of surviving breast cancer cells to evade innate and adaptive immunity.

  2. CD47 expression is decreased on the surface of erythrocytes in obese subjects. These changes in CD47 expression on the erythrocytes surface may be an adaptive response to hyperfibrinogenemia associated with obesity.

  3. Results show that the thrombospondin 1 (TSP1 (show THBS1 Antibodies)) and its receptor CD47 (CD47) axis selectively regulates NADPH oxidase 1 (Nox1 (show NOX1 Antibodies)) in the regulation of endothelial senescence and suggest potential targets for controlling the aging process at the molecular level.

  4. CD47 is overexpressed in primary non-small cell lung cancer (NSCLC) tissues and cell lines, suggesting that CD47 is a promising therapeutic target for NSCLC.

  5. Among the various candidate genes involved in acute rejection, CD47 inhibits monocyte/macrophage-mediated phagocytosis by identifying the CD47 signal regulatory protein alpha (SIRP (show SIRPA Antibodies)-alpha) as self/non-self. Tissue factor pathway inhibitor (TFPI (show TFPI Antibodies)) is involved in the regulation of the coagulation pathway and is able to bind to another ligand of CD47, thrombospondin-1 (TSP-1 (show THBS1 Antibodies)).

  6. Blocking CD47 using antibodies could efficiently induce macrophage-mediated phagocytosis of tumor cells and treat cancers.

  7. High CD47 expression is not associated with Fibrolamellar Hepatocellular Carcinoma.

  8. TTI-621 (SIRPalphaFc) is a fully human recombinant fusion protein that blocks the CD47-SIRPalpha axis by binding to human CD47 and enhancing phagocytosis of malignant cells..These data indicate that TTI-621 is active across a broad range of human tumors.

  9. this review highlights the various functions of CD47, discusses anti-tumor responses generated by both the innate and adaptive immune systems as a consequence of administering anti-CD47 blocking antibody, and finally elaborates on the clinical potential of CD47 blockade.

  10. we observed neutrophilic infiltration was slightly increased in anti-CD47 treated tumors compared to IgG control.

Pig (Porcine) CD47 interaction partners

  1. Amyloid-beta inhibits No-cGMP signaling in a CD36 (show CD36 Antibodies)- and CD47-dependent manner

  2. Genetic induction of human CD47 on porcine cells could provide inhibitory signaling to SIRPalpha on human macrophages, providing a novel approach to preventing macrophage-mediated xenograft rejection.

Cow (Bovine) CD47 interaction partners

CD47 Antigen Profile

Protein Summary

This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes. Alternatively spliced transcript variants have been found for this gene.

Gene names and symbols associated with anti-CD47 (CD47) Antibodies

  • CD47 antigen (Rh-related antigen, integrin-associated signal transducer) (Cd47) antibody
  • CD47 molecule (CD47) antibody
  • Cd47 molecule (Cd47) antibody
  • 9130415E20Rik antibody
  • AA407862 antibody
  • AI848868 antibody
  • AW108519 antibody
  • B430305P08Rik antibody
  • CD47/IAP antibody
  • IAP antibody
  • Itgp antibody
  • MER6 antibody
  • OA3 antibody

Protein level used designations for anti-CD47 (CD47) Antibodies

Rh-related antigen , integrin-associated protein , leukocyte surface antigen CD47 , CD47 antigen (Rh-related antigen, integrin-associated signal transducer) , CD47 glycoprotein , antigen identified by monoclonal antibody 1D8 , antigenic surface determinant protein OA3 , integrin associated protein , integrin-associated signal transducer , CD47 antigen , IAP

GENE ID SPECIES
16423 Mus musculus
961 Homo sapiens
478552 Canis lupus familiaris
397042 Sus scrofa
282661 Bos taurus
101111153 Ovis aries
29364 Rattus norvegicus
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