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CD48 encodes a member of the CD2 subfamily of immunoglobulin-like receptors which includes SLAM (signaling lymphocyte activation molecules) proteins. Additionally we are shipping CD48 Antibodies (344) and CD48 Kits (16) and many more products for this protein.
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Molecular dynamic simulation explains unbinding and unfolding of CD48-2B4 (show CD244 Proteins) protein complexes.
These data demonstrate the important role of CD48 in SA/exotoxins-eosinophil activating interactions that can take place during allergic responses and indicate CD48 as a novel therapeutic target for allergy and especially of AD.
ORMDL3 (show ORMDL3 Proteins) promotes eosinophil trafficking and activation via regulation of CD18 (show ITGB2 Proteins), CD49d, and CD48.
Ox-LDL significantly promoted the interaction of natural killer cells and dendritic cells via CD48-2B4 (show CD244 Proteins) contact-dependent mechanisms.
B6-specific background genes modulate the effect of CD48 on lupus nephritis in a recessive manner
CD48 plays a vital role as an environmental sensor for regulating hematopoietic stem cells and progenitor cell numbers and inhibiting tumor development
CD48 on surrounding NK or non-NK cells serves primarily as a ligand to stimulate 2B4 (show CD244 Proteins) on the adjacent NK cells in mice
CD137 (show TNFRSF9 Proteins) and CD28 (show CD28 Proteins) can promote bcl-2 (show BCL2 Proteins) expression at both mRNA and protein level in T cells.
molecular mechanism of heterophilic adhesion between the murine T-cell adhesion glycoprotein (show CD226 Proteins) CD2 (show CCND2 Proteins) and its ligand CD48
CD48 interactions with NK cell receptor 2B4 (show CD244 Proteins) among neighboring T cells during T cell priming augment CTL lysis of their specific targets.
mCD48 and sCD48 are differentially expressed in the peripheral blood of asthma patients of varying severity. sCD48 inhibits CD244 (show CD244 Proteins)-mediated eosinophil activation. These findings suggest that CD48 may play an important role in human asthma.
The present study provides further insights into the role of the 2B4 (show CD244 Proteins)-CD48 interaction in the fine regulation of CD8 (show CD8A Proteins)(+) T-cell effector function upon antigenic stimulation.
Data show that 2B4 (show CD244 Proteins) not only can bind to CD48 in trans but also interacts with CD48 in cis (show CISH Proteins) by using the same binding interface. Also, the results demonstrated that constitutive phosphorylation of 2B4 (show CD244 Proteins) occurs only in the presence of CD48, and that cis (show CISH Proteins) binding is sufficient to induce substantial levels of baseline phosphorylation.
Our data indicate sCD48 as a SEB-induced 'decoy' receptor derived from eosinophil and therefore as a potential anti-inflammatory tool in S. aureus-induced eosinophil inflammation often associated with allergy.
CD48 expression was increased in patients with a short disease duration compared to both controls and patients with longer disease duration. In patients with short disease duration, increased CD48 expression was associated with alveolar inflammation.
Blockade of 2B4 (show CD244 Proteins)/CD48 interaction resulted in improvement in function via perforin (show PRF1 Proteins) expression and degranulation as measured by CD107a (show LAMP1 Proteins) surface mobilization on HTLV-1 specific CD8 (show CD8A Proteins)+ T cells.
we propose that SLAMF2 engagement regulates adaptive immune responses
Monocyte-induced natural killer cell dysfunction was markedly attenuated by blocking CD48 receptor 2B4 (show CD244 Proteins) on NK cells, but not by blockade of NKG2D (show KLRK1 Proteins) and NKp30 (show NCR3 Proteins).
replication study of association of 2 SNPs in HERV-K18 (show KRT18 Proteins) and 19 tagSNPs in CD48 with schizophrenia (SZ)and type 2 diabetes (T2D) in patients with SZ in 2 Danish samples; no association was found with SZ or with T2D among individuals with SZ for any of the SNPs
This gene encodes a member of the CD2 subfamily of immunoglobulin-like receptors which includes SLAM (signaling lymphocyte activation molecules) proteins. The encoded protein is found on the surface of lymphocytes and other immune cells, dendritic cells and endothelial cells, and participates in activation and differentiation pathways in these cells. The encoded protein does not have a transmembrane domain, however, but is held at the cell surface by a GPI anchor via a C-terminal domain which maybe cleaved to yield a soluble form of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene.
BCM1 surface antigen
, MRC OX-45 surface antigen
, SLAM family member 2
, signaling lymphocytic activation molecule 2
, CD48 antigen
, B-lymphocyte activation marker BLAST-1
, CD48 antigen (B-cell membrane protein)
, leukocyte antigen MEM-102