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The protein encoded by CD63 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family.
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In renal proximal tubules, CD63 determines the insertion of OCT2 (show SLC22A2 Proteins) into the proper membrane domain and mediates transporter regulation by trafficking processes.
TIMP1 (show TIMP1 Proteins) signaling via CD63 leads to activation of hepatic stellate cells, which create an environment in the liver that increases its susceptibility to pancreatic tumor cells.
The Muted protein (show MUTED Proteins) is important for the steady-state level of CD63.
Data show that CD63 is a crucial player in the regulation of the tumor cell-intrinsic metastatic potential by affecting cell plasticity.
These findings identify CD63 as an important component of allergic inflammation.
CD63 serves to bridge between beta1 integrin and VEGFR2 (show KDR Proteins) because CD63 silencing disrupted VEGFR2 (show KDR Proteins)-beta1 integrin complex formation identified using proximity ligation assay
Loss of CD63 is associated impairment of amyloidogenesis and downstream melanosome morphogenesis.
Loss of CD63 has a similar phenotype to loss of P-selectin (show SELP Proteins) itself, thus CD63 is an essential cofactor to P-selectin (show SELP Proteins).
CXCR4 (show CXCR4 Proteins) can be downregulated on activated B cells by IL-21 (show IL21 Proteins)-induced endocytosis and CD63-mediated endosomal recruitment.
The findings identify palmitoylation-dependent association with the tetraspanin CD63 as the mechanism by which Syt VII (show SYT7 Proteins) is targeted to lysosomes.
our results identify the CD63-syntenin-1 (show SDCBP Proteins)-ALIX (show PDCD6IP Proteins) complex as a key regulatory component in post-endocytic HPV trafficking.
Exosomal markers CD63 and CD9 (show CD9 Proteins) are elevated in pancreatic tumor tissues.
CD63 and exosome expression is altered in scleroderma dermal fibroblasts
CD63 is a critical player in LMP1 (show PDLIM7 Proteins) exosomal trafficking and LMP1 (show PDLIM7 Proteins)-mediated enhancement of exosome production and may play further roles in limiting downstream LMP1 (show PDLIM7 Proteins) signaling.
Concentrations of Cd63 were elevated in gingival crevicular fluid of patients with pre-eclampsia.
CD163 (show CD163 Proteins)(+) TAMs in oral premalignant lesions coexpress CD163 (show CD163 Proteins) and STAT1 (show STAT1 Proteins), suggesting that the TAMs in oral premalignant lesions possess an M1 phenotype in a Th1 (show TH1L Proteins)-dominated micromilieu.
Our findings reveal that elevated levels of TIMP-1 (show TIMP1 Proteins) impact on neutrophil homeostasis via signaling through CD63.
These findings indicate that rhTIMP-1 promotes clonogenic expansion and survival in human progenitors via the activation of the CD63/PI3K (show PIK3CA Proteins)/pAkt (show AKT1 Proteins) signaling pathway
It was shown that treatment of macrophages with anti-CD63 inhibits CCR5-mediated virus infection in a cell type-specific manner, but that no inhibition of CXCR4 (show CXCR4 Proteins)-tropic viruses occurs.
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Alternative splicing results in multiple transcript variants encoding different protein isoforms.
melanoma 1 antigen
, CD63 antigen
, CD63 antigen (melanoma 1 antigen)
, lysosomal-associated membrane protein 3
, lysosome-associated membrane glycoprotein 3
, melanoma-associated antigen ME491
, melanoma-associated antigen MLA1
, ocular melanoma-associated antigen
, ME491/CD63 antigen
, mast cell antigen AD1