CD70 Molecule (CD70) ELISA Kits

The protein encoded by CD70 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. Additionally we are shipping CD70 Antibodies (264) and CD70 Proteins (37) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
CD70 21948 O55237
CD70 970 P32970
Anti-Rat CD70 CD70 301132  
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Top CD70 ELISA Kits at antibodies-online.com

Showing 3 out of 19 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Mouse 10pg/mL 31.2-2000 pg/mL Mouse CD70/TNFSF7/cd27L PicoKine ELISA Kit standard curve 96 Tests Log in to see 4 to 6 Days
$369.00
Details
Human 0.039 ng/mL 0.156-10 ng/mL Typical standard curve 96 Tests Log in to see 15 to 18 Days
$910.56
Details
Pig
  96 Tests Log in to see 15 to 18 Days
$1,029.60
Details

More ELISA Kits for CD70 Interaction Partners

Mouse (Murine) CD70 Molecule (CD70) interaction partners

  1. that both human and mouse CD70-specific CAR T cells recognize primary CD70+ glioblastomas (GBM) tumors in vitro and mediate the regression of established GBM in xenograft and syngeneic models without illicit effect

  2. CD70 mitigates atherosclerosis at least in part by modulating macrophage function.

  3. these findings demonstrate for the first time, to our knowledge, that T cell-derived CD70 plays a novel immune checkpoint role in inhibiting inflammatory T cell responses

  4. findings demonstrate that host CD70 serves as a unique negative regulator of allogeneic T cell response by contributing to donor T cell apoptosis and inhibiting expansion of donor effector T cells.

  5. CD70 reverse signaling enhances NK cell function and immunosurveillance in CD27-expressing B-cell malignancies.

  6. Mice lacking CD70 did not accumulate memory T cells and did not develop hypertension.

  7. find that while stimulation of CD27 in isolation drives weak Eomesodermin(hi) T-bet(lo) CD8(+) T-cell responses to OVA immunization

  8. Data show that although CD70 is required for the activation of the antiviral adaptive response, it has a regulatory role in early cytokine responses to viruses such as MCMV, possibly through maintenance of Treg survival and function.

  9. the ability of CD70 to trigger costimulation is self-regulated when it binds its complementary receptor.

  10. under conditions of constitutive CD70 expression reflecting chronic immune activation, the CD27/CD70 system inhibits OC differentiation and favors DC differentiation

  11. mTECs and DCs form dedicated niches in the thymic medulla, in which CD27-CD70 co-stimulation rescues developing Treg cells from apoptosis, subsequent to Foxp3 induction by TCR and CD28 signals.

  12. Expression of CD70 by B cells aggravates experimental autoimmune encephalomyelitis by reducing the number of regulatory T cells.

  13. CD70-deficient mice infected with lymphocytic choriomeningitis virus produced only half as many T8 cells. Viral clearance was substantially delayed. CD70-mediated costimulation is not required for secondary or T4 responses.

  14. The CD27 and CD70 costimulatory pathway inhibits effector function of T helper 17 cells and attenuates associated autoimmunity.

  15. population of CD27(-) Th2 cells was significantly reduced by the anti-CD70 mAb treatment

  16. The CD4+ T-cell help signal is transmitted from APC to CD8+ T-cells via CD27-CD70 interactions.

  17. Although CD70 is required for dendritic cell-mediated delay of T cell tolerance induction, CD80 and CD86 are necessary for refunctionalizing the tolerized T cells in prostate tumor tissue

  18. CD70-driven costimulation induces survival or Fas-mediated apoptosis of T cells depending on antigenic load.

  19. Our findings suggest that antigen persistence may determine the opposing effects of CD27/CD70 signaling on CD8 T cell responses during acute and chronic lymphocytic choriomeningitis virus infection of mice.

  20. Adoptively transferred CD70-specific T cells induced sustained regression of established murine xenografts.

Human CD70 Molecule (CD70) interaction partners

  1. that both human and mouse CD70-specific CAR T cells recognize primary CD70+ glioblastomas (GBM) tumors in vitro and mediate the regression of established GBM in xenograft and syngeneic models without illicit effect

  2. This dose-escalation phase I trial provides evidence of good tolerability of ARGX-110, pharmacokinetics, and preliminary antitumor activity at all dose levels in generally heavily pretreated patients with advanced CD70-positive malignancies

  3. Results show that CD70 promoter region methylation and expression are regulated by MBD4. Indeed, the study shows that downregulation of MBD4 contributed to overexpression and hypomethylation of the CD70 gene in CD4+ T cells from patients from systemic lupus erythematosus.

  4. CD70 mitigates atherosclerosis at least in part by modulating macrophage function.

  5. Preclinical testing supports the safety and efficacy of a CD27-containing CAR targeting CD70-expressing tumors

  6. This study demonstrated that Expression of CD70 (CD27L) Is Associated With Epithelioid and Sarcomatous Features in IDH-Wild-Type Glioblastoma.

  7. CD27 is engaged by CD70 cross-presented by other AML blasts or stem/progenitor cells in a paracrine manner.

  8. the CD70-CD27 pathway appears to be a crucial component of EBV-specific T cell immunity and more generally for the immune surveillance of B cells and may be a target for immunotherapy of B cell malignancies.

  9. human CD70-CD27 interactions therefore play a nonredundant role in T and B cell-mediated immunity, especially for protection against EBV and humoral immunity.

  10. These data demonstrate the important role of the CD70/CD27 axis in immune responses in HTLV-1 carriers and ATL patients.

  11. CD70: An emerging target in cancer immunotherapy

  12. Both monomeric and trimeric forms of CD70 were detected in tumour cell membrane fractions, whereas cytoplasmic fractions contained almost exclusively monomeric CD70

  13. CD70 is overexpressed in systemic lupus erythematosus CD4+ T cells, but expression is not linked to the typical clinical and serological parameters associated with the disease.

  14. CD70-blocking of alphaDC1s from both controls and patients with chronic lymphocytic leukaemia had a negative influence on the production of both IL-12p70 and the Th1 cytokine IFN-gamma.

  15. These results highlight the importance of the CD27-CD70 costimulation pathway for the development of CMV-specific T cell immunity during acute and persistent infection.

  16. CD70 acts as a functional receptor binding to soluble CD27, resulting in lymphoma progression and that immunotherapy using anti-CD70 antibody may be a potential candidate for treatment for NNKTL.

  17. These results indicate that CD27 and CD70 gene polymorphisms may affect the risk of breast cancer and show that some SNPs are associated with breast cancer characteristics in a northern Chinese population.

  18. The mean expression of CD70 was almost twice as high in renal cell carcinoma relative to normal kidney tissue

  19. Regulation of Langerhans cell CD70 expression is important in enhancing immunity against cutaneous epithelial pathogens and cancer.

  20. Findings suggest that demethylation of CD70 promoter region contributes to the overexpression of CD70 in CD4+ T cells and may contribute to autoimmune response in systemic sclerosis (SSc).

CD70 Antigen Profile

Antigen Summary

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.

Gene names and symbols associated with CD70 Molecule (CD70) ELISA Kits

  • CD70 antigen (Cd70) antibody
  • CD70 molecule (CD70) antibody
  • Cd70 molecule (Cd70) antibody
  • CD27L antibody
  • CD27LG antibody
  • TNFSF7 antibody

Protein level used designations for CD70 Molecule (CD70) ELISA Kits

CD27 ligand , CD27-L , Ki-24 antigen , tumor necrosis factor (ligand) superfamily, member 7 , tumor necrosis factor ligand superfamily member 7 , CD70 antigen , surface antigen CD70

GENE ID SPECIES
21948 Mus musculus
970 Homo sapiens
733577 Sus scrofa
301132 Rattus norvegicus
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