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Plays a role in B-cell proliferation and differentiation..
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CD72 appears to specifically inhibit B cell response to the endogenous TLR7 (show TLR7 Proteins) ligand Sm/RNP (show RNPC3 Proteins).
CD72 negatively regulates mouse mast cell functions and down-regulates the expression of KIT and FcepsilonRIalpha.
CD5 (show CD5 Proteins) and CD72 play a critical role in maintaining regulatory T and B cell homeostasis
These results strongly suggest that the Cd72(c) is a crucial modifier gene that regulates Fas(lpr (show FAS Proteins))-induced autoimmune disease due to its reduced activity of B cell signal regulation.
Cd72 polymorphism affects susceptibility to lupus phenotypes.
Inhibitory coreceptors CD72 and CD22 (show CD22 Proteins) are responsible for setting the requirement of CD40 (show CD40 Proteins) signaling for survival and proliferation of antigen-stimulated spleen B cells.
results strongly suggest that the apoptosis preventing signal evoked by CD72 ligation is delivered through the pathway of NF-kappaB (show NFKB1 Proteins), c-Myc (show MYC Proteins), p27(Kip1 (show CDKN1B Proteins)) and cyclin (show PCNA Proteins)
Strength of B-cell antigen receptor signals is strictly tuned by the interaction of CD100 (show SEMA4D Proteins) with CD72; this interaction is essential for maintaining immunological homeostasis as well as generating a proper immune response.
CD72 plays a dominant role as a negative regulator of BCR (show BCR Proteins) signaling in primary mature B lymphocytes.
CD72 is required to maintain B cell anergy and functions as a regulator of peripheral B cell tolerance
Interferon-alpha (show IFNA Proteins)-induced CD100 (show SEMA4D Proteins) expression on naive CD8 (show CD8A Proteins)(+) T cells enhances antiviral responses to hepatitis C infection through CD72 signal transduction.
Increased soluble CD72 in systemic lupus erythematosus is in association with disease activity and lupus nephritis
CD72 expression on activated B cells of SLE patients was significantly lower than that of normal controls. sema3A (show SEMA3A Proteins) enhanced CD72 expression of B cells, but it was still lower in SLE patients than in normal individuals.
data demonstrated aberrant expression of CD72 exists on B cells of myasthenia gravis and multiple sclerosis patients and expression level of CD72 molecule has a significantly negative correlation with anti-AchR antibody levels in myasthenia gravis
CD72 mRNA expression level correlates with Sema4D (show SEMA4D Proteins) expression in peripheral blood mononuclear cells in immune thrombocytopenia.
CD100 (show SEMA4D Proteins), CD72 and CD45 (show PTPRC Proteins) were expressed in placenta and exhibited different mRNA and protein levels in normal pregnancy and miscarriage. Protein levels were highly dysregulated around 10 weeks of gestation in first and second miscarriage placentas.
CD100 (show SEMA4D Proteins)-CD72 interaction can be the mechanism by which NK cell communicate with B cells.
Data show that ligation of CD72 with the BU40, or with rCD100 negatively regulates KIT-mediated mast cell proliferation, chemotaxis, and chemokine (show CCL1 Proteins) production.
results indicated that the presence of CD72-*2 allele decreases risk for human systemic lupus erythematosus conferred by FCGR2B-232Thr, possibly by increasing the AS isoform of CD72
CD72 is a key molecule in regulating mature B cell differentiation; CD72 signaling reduces the expression of X-box binding protein 1 (show XBP1 Proteins) in B cells
Plays a role in B-cell proliferation and differentiation.
B-cell differentiation antigen CD72
, lymphocyte antigen 32
, CD72 antigen