CKLF-Like MARVEL Transmembrane Domain Containing 6 Proteins (CMTM6)

CMTM6 belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and transmembrane 4 superfamilies. Additionally we are shipping CMTM6 Kits (41) and CMTM6 Antibodies (24) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CMTM6 67213 Q9CZ69
CMTM6 54918 Q9NX76
Rat CMTM6 CMTM6 316035  
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Top CMTM6 Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$5,262.31
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
$7,493.38
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 11 Days
$547.80
Details
Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 11 to 18 Days
$582.75
Details

CMTM6 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , , ,
, ,

More Proteins for CKLF-Like MARVEL Transmembrane Domain Containing 6 (CMTM6) Interaction Partners

Human CKLF-Like MARVEL Transmembrane Domain Containing 6 (CMTM6) interaction partners

  1. CMTM6 plays an important role in regulating T cell activation and antitumor responses.

  2. CMTM6 is present at the cell surface, associates with the PD-L1 protein, reduces its ubiquitination and increases PD-L1 protein half-life; CMTM6 enhances the ability of PD-L1-expressing tumour cells to inhibit T cells; collectively, our data reveal that PD-L1 relies on CMTM6/4 to efficiently carry out its inhibitory function, and suggest potential new avenues to block this pathway

  3. CMTM6 depletion, via the reduction of PD-L1, significantly alleviates the suppression of tumour-specific T cell activity in vitro and in vivo; findings provide insights into the biology of PD-L1 regulation, identify a previously unrecognized master regulator of this critical immune checkpoint and highlight a potential therapeutic target to overcome immune evasion by tumour cells

  4. Bioinformatics based on CKLF2 cDNA and protein sequences in combination with experimental validation identified CKLFSF1-8 gene clusters, between the SCY and the TM4SF gene families. The 8 family members were cloned and characterized.

CMTM6 Protein Profile

Protein Summary

This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene is widely expressed in many tissues, but the exact function of the encoded protein is unknown.

Gene names and symbols associated with CMTM6

  • CKLF-like MARVEL transmembrane domain containing 6 (cmtm6)
  • CKLF like MARVEL transmembrane domain containing 6 (CMTM6)
  • CKLF-like MARVEL transmembrane domain containing 6 (Cmtm6)
  • CKLF like MARVEL transmembrane domain containing 6 (Cmtm6)
  • 2810051A14Rik protein
  • AA536733 protein
  • Cklfsf6 protein
  • Da2-17 protein
  • DKFZp469L0821 protein
  • LRRGT00102 protein
  • MGC127534 protein
  • PRO2219 protein
  • sb:cb551 protein
  • si:dkey-11p23.2 protein
  • wu:fc75b06 protein

Protein level used designations for CMTM6

CKLF-like MARVEL transmembrane domain-containing protein 6 , chemokine-like factor super family 6 , chemokine-like factor superfamily 6 , CKLF-like MARVEL transmembrane domain containing 6 , chemokine-like factor superfamily member 6

GENE ID SPECIES
368348 Danio rerio
420667 Gallus gallus
508881 Bos taurus
548405 Xenopus (Silurana) tropicalis
609718 Canis lupus familiaris
704441 Macaca mulatta
746602 Pan troglodytes
100171512 Pongo abelii
67213 Mus musculus
54918 Homo sapiens
316035 Rattus norvegicus
100717163 Cavia porcellus
Selected quality suppliers for CMTM6 Proteins (CMTM6)
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