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CMTM6 belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and transmembrane 4 superfamilies. Additionally we are shipping CMTM6 Kits (41) and CMTM6 Antibodies (24) and many more products for this protein.
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CMTM6 is present at the cell surface, associates with the PD-L1 (show CD274 Proteins) protein, reduces its ubiquitination and increases PD-L1 (show CD274 Proteins) protein half-life; CMTM6 enhances the ability of PD-L1 (show CD274 Proteins)-expressing tumour cells to inhibit T cells; collectively, our data reveal that PD-L1 (show CD274 Proteins) relies on CMTM6/4 to efficiently carry out its inhibitory function, and suggest potential new avenues to block this pathway
CMTM6 depletion, via the reduction of PD-L1 (show CD274 Proteins), significantly alleviates the suppression of tumour-specific T cell activity in vitro and in vivo; findings provide insights into the biology of PD-L1 (show CD274 Proteins) regulation, identify a previously unrecognized master regulator of this critical immune checkpoint and highlight a potential therapeutic target to overcome immune evasion by tumour cells
Bioinformatics based on CKLF2 (show CKLF Proteins) cDNA and protein sequences in combination with experimental validation identified CKLFSF1 (show CMTM1 Proteins)-8 gene clusters, between the SCY and the TM4SF (show TSPAN1 Proteins) gene families. The 8 family members were cloned and characterized.
This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene is widely expressed in many tissues, but the exact function of the encoded protein is unknown.
CKLF-like MARVEL transmembrane domain-containing protein 6
, chemokine-like factor super family 6
, chemokine-like factor superfamily 6
, CKLF-like MARVEL transmembrane domain containing 6
, chemokine-like factor superfamily member 6