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The protein encoded by COPS3 possesses kinase activity that phosphorylates regulators involved in signal transduction.
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Here the authors identify a potential mechanism by which desmosomes assist the de-neddylating COP9 (show COPS8 Antibodies) signalosome (CSN) in attenuating EGFR (show EGFR Antibodies) through an association between the Cops3 subunit of the CSN and desmosomal components, Desmoglein1 (Dsg1 (show DSG1 Antibodies)) and Desmoplakin (Dp (show DSP Antibodies)), to promote epidermal differentiation.
this study demonstrates Csn3 (show CSN3 Antibodies) as an oncogene (show RAB1A Antibodies) that regulates the tumorigenesis process in hepatocellular carcinoma (HCC (show FAM126A Antibodies)) cells.
of the COPS3 gene might have important roles in metastasis of osteosarcoma cells.
This is the first study toward understanding the role of the CSN3 (show CSN3 Antibodies) in skeletal muscle differentiation and proliferation. Our results show that knockdown of CSN3 (show CSN3 Antibodies) in C2C12 cells leads to impaired differentiation, proliferation and cell cycle regulation of myoblasts.
CSN3 (show CSN3 Antibodies) and CSN5 (show COPS5 Antibodies) are involved in oocyte meiosis by regulating degradation of Cyclin B1 (show CCNB1 Antibodies) and Securin (show PTTG1 Antibodies) via APC (show APC Antibodies)/C.
Cops3 encodes the third subunit of the COP9 (show COPS8 Antibodies) signalosome, which controls a wide vasriety of molecules of different functions.
The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I kappa-Balpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene.
COP9 complex subunit 3
, COP9 constitutive photomorphogenic homolog subunit 3
, COP9 signalosome complex subunit 3
, JAB1-containing signalosome subunit 3
, signalosome subunit 3
, COP9 (constitutive photomorphogenic), subunit 3
, COP9 complex S3