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CTDSPL encodes an essential structural component of the synaptonemal complex.
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data suggest that overexpression of p-RB1 (show RB1 Proteins) in basal-parabasal layers of normal cervical epithelium was due to methylation/low functional-linked non-synonimous SNPs of P16 and RBSP3. This pattern was maintained during cervical carcinogenesis by additional deletion/mutation
CTDSPL and Rb directly interact and can be involved in the common mechanism of cell cycle regulation.
identified RBSP3, a phosphatase-like tumor suppressor, as a bona fide target of miR (show MLXIP Proteins)-100 and validated that RBSP3 was involved in cell differentiation and survival in acute myeloid leukemia (show BCL11A Proteins)
tumor suppressor genes RBSP3/CTDSPL, NPRL2/G21 (show NPRL2 Proteins) and RASSF1A (show RASSF1 Proteins) are downregulated in primary non-small cell lung cancer
dysregulation of hMLH1 (show MLH1 Proteins), ITGA9, and RBSP3 associated multiple cellular pathways are needed for the development of early dysplastic lesions of the head and neck.
In cervical intraepithelial neoplasms and uterine cervical carinoma, RBSP3 is oftne deletd, compared with other genes.
analysis of RBSP3/HYA22located in the AP20 region, and evidence for tumor suppressor function
SCP3 acts as a phosphatase for regulatory phosphorylations in the linker regions of Smad1 (show GARS Proteins) and Smad2 (show SMAD2 Proteins).
Frequent alterations of RBSP3 at chromosomal 3p22.3 region in early and late-onset breast carcinoma are reported with reference to clinical and prognostic significance.
Down-regulation of RBSP3/CTDSPL, NPRL2/G21 (show NPRL2 Proteins), RASSF1A (show RASSF1 Proteins), ITGA9, HYAL1 (show HYAL1 Proteins) and HYAL2 (show HYAL2 Proteins) genes in non-small cell lung cancer
R-Smads are the key components of TGFbeta (show TGFB1 Proteins) beta signals in germ layer induction. SCP3 (show SYCP3 Proteins) serves as a vegetally enriched, intrinsic factor (show GIF Proteins) to ensure a prepared status of Smads for their activation.
This gene encodes an essential structural component of the synaptonemal complex. This complex is involved in synapsis, recombination and segregation of meiotic chromosomes. Mutations in this gene are associated with azoospermia in males and susceptibility to pregnancy loss in females. Alternate splicing results in multiple transcript variants that encode the same protein.
CTD small phosphatase-like protein
, NIF-like protein
, NLI-interacting factor 1
, RB protein serine phosphatase from chromosome 3
, carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 3
, nuclear LIM interactor-interacting factor 1
, small C-terminal domain phosphatase 3
, small CTD phosphatase 3
, small CTD phosphatase 3-like
, NLI/Ldb1/CLIM interacting factor
, CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
, CTD small phosphatase like L homeolog
, CTD small phosphatase like S homeolog