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The protein encoded by CELSR3 is a member of the flamingo subfamily, part of the cadherin superfamily. Additionally we are shipping CELSR3 Antibodies (79) and CELSR3 Proteins (5) and many more products for this protein.
Study identifies four likely Tourette disorder risk genes with multiple de novo damaging variants in unrelated probands: WWC1 (WW and C2 domain containing 1 (show WWC1 ELISA Kits)), CELSR3 (Cadherin EGF LAG seven-pass G-type receptor 3), NIPBL (show NIPBL ELISA Kits) (Nipped (show RPL38 ELISA Kits)-B-like), and FN1 (fibronectin 1 (show FN1 ELISA Kits)).
marked reduction in the prominence of TUJ1 bundles in number, thickness, and length. Our results showed that deregulation of the planar cell polarity genes CELSR3 and FZD3 (show FZD3 ELISA Kits) might disrupt the enteric innervation pattern
A moderate positive correlation between CELSR3 and patient age was also evident.
seven-transmembrane domain receptors Celsr3 and Fzd3 (show FZD3 ELISA Kits), in particular, control the development of most longitudinal tracts in the central nervous system. [Review]
CELSR3 promoter hypermethylation is associated with oral squamous cell carcinoma.
CELSR3 was found to be selectively up-regulated in tumor stellate cells.
CELSR3 is one of the core PCP (show PRCP ELISA Kits) signaling molecules.
Results suggest that Celsr3 and Fzd3 (show FZD3 ELISA Kits) orchestrate the formation of a scaffold of pioneer neurons and their axons during embryogenesis. This scaffold extends from prethalamus to ventral telencephalon and subcortex, and steers reciprocal corticothalamic fibers.
Celsr3 and Fzd3 (show FZD3 ELISA Kits) enable immature neurons to respond to Wnt7 (show WNT7B ELISA Kits), upregulate Jag1 (show JAG1 ELISA Kits) and thereby facilitate feedback signals that tune the timing of neural progenitor cell fate decisions via Notch (show NOTCH1 ELISA Kits) activation.
Our results provide evidence that the Celsr3-Fzd3 (show FZD3 ELISA Kits) pathway interacts with EphA-ephrinA reverse signaling to guide motor axons in the hindlimb.
The essential role of Celsr3 in globus pallidus development.
The first signal, controlled by cadherin, EGF (show EGF ELISA Kits)-like, laminin G-like, seven-pass, G-type receptor (Celsr) 2 (show CELSR2 ELISA Kits), Celsr3, Frizzled3 (Fzd3 (show FZD3 ELISA Kits)) and Van Gogh (show VANGL2 ELISA Kits) like2 (Vangl2 (show VANGL2 ELISA Kits)) organizes multicilia in individual cells (single-cell polarity)
Celsr2 (show CELSR2 ELISA Kits)-3 and Fzd3 (show FZD3 ELISA Kits) regulate axonal navigation in the forebrain by using mechanisms different from classical epithelial core planar cell polarity, and require interacting partners other than Vangl1 (show Vangl1 ELISA Kits)-2 that remain to be identified.
This study demonistrated that Celsr3/Foxg1 (show FOXG1 ELISA Kits) mutation mice show the spinal motor network does not mature fully in the absence of corticofugal connections, and that some motor function is preserved despite congenital absence of the corticospinal tract.
Celsr3 and Fzd3 (show FZD3 ELISA Kits) are required during murine embryogenesis to specifically control the guidance and growth of enteric neuronal projections relative to the longitudinal and radial gut (show GUSB ELISA Kits) axes.
Celsr3/Foxg1 & Celsr3/Dlx mutant mice were hyperactive, learning- & memory-impaired. Celsr3/Foxg1 caused abnormal cytoarchitecture of CA1, CA3, & dentate gyrus. Celsr3|Dlx mildly affected hippocampal and extrinsic & intrinsic connectivity.
Celsr2 (show CELSR2 ELISA Kits) and Celsr3 control the development and function of ependymal cilia; findings suggest that planar cell polarity signaling is involved in ependymal cilia development and in the pathophysiology of hydrocephalus, and possibly other ciliopathies
The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins\; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined.
EGF-like protein 1
, EGF-like-domain, multiple 1
, anchor protein
, cadherin EGF LAG seven-pass G-type receptor 3
, cadherin family member 11
, cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)
, epidermal growth factor-like protein 1
, flamingo homolog 1
, multiple EGF-like domains protein 2
, multiple epidermal growth factor-like domains protein 2
, multiple epidermal growth factor-like domains 2