Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 1 (CACNA2D1) ELISA Kits

CACNA2D1 encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Additionally we are shipping CACNA2D1 Antibodies (81) and CACNA2D1 Proteins (8) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human CACNA2D1 CACNA2D1 781 P54289
Anti-Mouse CACNA2D1 CACNA2D1 12293 O08532
CACNA2D1 25399  
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Catalog No. Reactivity Sensitivity Range Images Quantity Delivery Price Details
Rat 7.81 pg/mL 31.25-2000 pg/mL Typical standard curve 96 Tests 15 to 18 Days

More ELISA Kits for CACNA2D1 Interaction Partners

Human Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 1 (CACNA2D1) interaction partners

  1. TROY may therefore be a new molecular marker to aid in identifying and selecting patients undergoing radical cystectomy who could potentially benefit from multimodal treatment.

  2. Using human genome-wide association study (GWAS) data, evidence for association of a CACNA2D1 single-nucleotide polymorphism and primary open angle glaucoma is found.

  3. we report an additional patient with the 7q21.11 deletion syndrome and provide evidence that haploinsufficiency for a single gene may not be the disease mechanism. In vitro studies of the interaction between PCLO and CACNA2D1 will be required to examine the hypothesis that combined haploinsufficiency for these two synaptic proteins results in neuronal dysfunction

  4. detected a joint effect of SNP and G x E interaction in BMP2 and CACNA2D1 for depressive state.

  5. All three patients present with epilepsy and intellectual disability pinpointing the CACNA2D1 gene as an interesting candidate gene for these clinical features.

  6. Compound mutation of CACNA2D1 and RANGRF genes were found. To the best of our knowledge, this is the first comprehensive description of the concurrence of these two mutations and histiocytoid cardiomyopathy.

  7. High prevalence of CACNA2D1, SCN5A, and CACNB2 genetic variants in the Danish population previously associated with Brugada syndrome has been found in new exome data.

  8. Functional expression of CACNA2D1 is inhibited by prion protein expression with competition at glycosylphosphatidylinositol.

  9. this study reports the identification and characterization of the human alpha2delta-1 subunit gene promoter region and its regulation by specific transcription factor 1.

  10. (Review) In neurons, alpha2delta1 subunits are present mainly in presynaptic terminals; peripheral sensory nerve injury results in up-regulation of alpha2delta1 in dorsal root ganglion neurons, and there is consequent increase in trafficking of alpha2delta1 to their terminals.

  11. In neocortical slices from transgenic mice having a point mutation (i.e., R217A) of the alpha2delta-1 subunit of voltage-sensitive calcium channels, pregabalin does not affect potassium-evoked glutamate release, yet inhibits this release in wild-type mice.

  12. Results show that mutation of CACNA2D1 gene causes a new varant of SCTS.

  13. CACNA2D1 is a novel Brugada Syndrome susceptibility gene.

  14. CACNA2D1 has structural domains which contribute to the regulation of N-type calcium channel inactivation

  15. loss-of-function mutations in genes encoding the cardiac L-type calcium channel to be associated with a familial sudden cardiac death syndrome in which a Brugada syndrome phenotype is combined with shorter-than-normal QT intervals

  16. Ion channel gating is regulated by calcium and calmodulin binding.

  17. Timothy syndrome is a disease of excessive cellular Ca(2+) entry and life-threatening arrhythmias caused by a mutation in the primary cardiac L-type Ca(2+) channel (Ca(V)1.2).

Rabbit Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 1 (CACNA2D1) interaction partners

  1. data support a model in which small neutral hydrophobic residues facilitate the post-translational cleavage of the CaValpha2delta1 subunit at the predicted membrane interface and further suggest that preventing GPI anchoring of CaValpha2delta1 averts its cell-surface expression

  2. these findings provide evidence for a new role of Homer1 supporting the regulation of Cav1.2 channels by STIM1.

Pig (Porcine) Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 1 (CACNA2D1) interaction partners

  1. analgesic actions of pregabalin are mediated through the alpha2-delta-1 subunit of voltage-gated calcium channels and establish this subunit as a therapeutic target for pain control

Cow (Bovine) Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 1 (CACNA2D1) interaction partners

  1. Based on the impact of both candidate genes,TLR4 and CACNA2D1, on udder health, linear or generalized linear mixed models was applied for testing the associations of SNPs located in the genes and clinical mastitis

  2. Results show that expression level decline in each genotypic group after treatment and expression level of GG are again significantly higher than AA and AG.

  3. The objective of the present study was to identify polymorphisms of the CACNA2D1 gene, and to analyze associations between these polymorphisms and mastitis in several cattle breeds.

  4. CACNA2D1 gene is one of the potential candidate genes influencing carcass and meat quality traits.

Mouse (Murine) Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 1 (CACNA2D1) interaction partners

  1. Cacna2d1 overexpression potentiates presynaptic and postsynaptic NMDAR activity of spinal dorsal horn neurons to cause pain hypersensitivity.

  2. large conductance calcium-activated potassium (BK) channels interact with the Cavalpha2delta subunit.

  3. the interaction between alpha2delta-1 and NMDARs is of high physiological relevance

  4. Cacna2d1 regulated the intraocular pressure and glaucoma susceptibility.

  5. Study identified a critical role for alpha2delta-1 in freeze-lesion-induced developmental cortical malformation pathologies and in mediating the neuroprotective effects of gabapentin (GBP). Genetic deletion of alpha2delta-1 did not eliminate GBP's effects on synaptogenesis, suggesting that GBP can have alpha2delta-1-independent effects.

  6. Results show that overexpression of alpha2delta-1 alone in TG mice can enhance excitatory connectivity in neocortex and lead to neural circuit hyperexcitability and episodes of electrographic epileptiform activity, associated with behavioral arrests in transgenic mice.

  7. Loss of the Ca(2+) channel alpha2delta-1 subunit function increases the susceptibility for developing diabetes in a sex-dependent manner.

  8. Linkage mapping, transcript covariance and pharmacological testing suggest that genetic variation affecting Cacna2d1 may contribute to individual differences in von Frey filament response.

  9. a TSP4/Cavalpha2delta1-dependent pathway activated by TSP4 or peripheral nerve injury promotes exaggerated presynaptic excitatory input and evoked sensory neuron hyperexcitability and excitatory synaptogenesis.

  10. Our findings support a role of peripheral nerve injury-induced alpha2delta1 in enhancing pre-synaptic excitatory

  11. CaV2.2 and alpha2delta-1 are intimately associated at the plasma membrane

  12. These results suggest calcium channel-independent effects of alpha2delta-1 on feeding and implicate alpha2delta-1-thrombospondin interactions known to facilitate excitatory synapse assembly

  13. These findings suggest that the alpha(2)delta(4) subunit participates in the modulation of L-type Ca(2+) current regulating neurotransmitter release from photoreceptor terminals

  14. alpha2delta-1 is essential for rapid development of mechanical hypersensitivity in a nerve injury model of neuropathic pain.

  15. Expression of Cacna2d1 is enhanced in the amygdala in a model of innate anxiety.

  16. This study of the rabbit ortholog of dihydropyridine-sensitive calcium channel alpha 2 provides N-terminal sequencing evidence of the cleavage junction of the alpha2 and delta subunits from the preprotein

  17. This study demonistrated that Cacna2d1 gene expression in mouse dorsal raphe nucleus

  18. The alpha(2) delta(1) subunit, previously described as an L-type auxiliary subunit, complexes with the T-type Ca(v)3.2 (alpha(1H)) subunit in MLO-Y4 cells.

  19. association of calcium channel alpha2/delta subunit 1 and ATP5b occurs in intracellular membranes and at the plasma membrane of developing muscle cells, where they form a signaling complex capable of accelerating the rate of decline of calcium transients

  20. Upregulation of alpha(2)/delta subunit of VGCC in the frontal cortex and the limbic forebrain plays a critical role in development of morphine-induced rewarding effect and behavioral sensitization following neuronal plasticity.

CACNA2D1 Antigen Profile

Antigen Summary

This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

Gene names and symbols associated with CACNA2D1

  • calcium voltage-gated channel auxiliary subunit alpha2delta 1 (CACNA2D1) antibody
  • calcium channel, voltage-dependent, alpha 2/delta subunit 1 (cacna2d1) antibody
  • calcium voltage-gated channel auxiliary subunit alpha2delta 1 (cacna2d1) antibody
  • calcium voltage-gated channel auxiliary subunit alpha2delta 1 (Cacna2d1) antibody
  • calcium channel, voltage-dependent, alpha2/delta subunit 1 (Cacna2d1) antibody
  • Ca(v)alpha2delta1 antibody
  • Cacna2 antibody
  • CACNA2D1 antibody
  • CACNL2A antibody
  • Cchl2a antibody
  • CCHLA2 antibody
  • DHSCCA antibody
  • DKFZp469K2211 antibody

Protein level used designations for CACNA2D1

calcium channel, voltage-dependent, alpha 2/delta subunit 1 , voltage-dependent calcium channel subunit alpha-2/delta-1-like , calcium channel, L type, alpha 2 polypeptide , dihydropyridine-sensitive L-type, calcium channel alpha-2/delta subunit , voltage-dependent calcium channel subunit alpha-2/delta-1 , voltage-gated calcium channel subunit alpha-2/delta-1 , dihydropryridine-sensitive calcium channel alpha-2 subunit , dihydropyridine-sensitive calcium channel alpha 2 , Calcium channel subunit alpha 2 delta (dihydropyridine - sensitive L-type)

463504 Pan troglodytes
708215 Macaca mulatta
100012746 Monodelphis domestica
100036724 Xenopus (Silurana) tropicalis
100171724 Pongo abelii
100463812 Ailuropoda melanoleuca
100566428 Anolis carolinensis
100595072 Nomascus leucogenys
781 Homo sapiens
100009105 Oryctolagus cuniculus
100728887 Cavia porcellus
768444 Gallus gallus
610342 Canis lupus familiaris
397377 Sus scrofa
282608 Bos taurus
12293 Mus musculus
25399 Rattus norvegicus
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