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CIB1 encodes a member of the EF-hand domain-containing calcium-binding superfamily.
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this study identifies CIB1 and CIB2 (show CIB2 ELISA Kits) as host helper factors for HIV-1 replication that are required for optimal receptor-mediated viral entry
In summary, as a multifunctional protein, CIB1 serving not only as a Ca2 (show CA2 ELISA Kits)+ modulating protein, most surprisingly, but also as an important potential tumor promoting factor. [review]
Results suggest that interaction of CIB1 with alphaIIb is one of the early events occurring during outside-in signaling. Furthermore, CIB1 recruits FAK to the alphaIIbbeta3 complex at the filopodia where FAK is activated, which in turn activates c-Src, resulting in propagation of outside-in signaling leading to platelet spreading.
we found that ectopic expression of oncogenic KRas and HRas (show HRAS ELISA Kits) in cells resulted in elevated CIB1 expression. We previously described the Ca(2 (show CA2 ELISA Kits)+)-myristoyl switch function of CIB1, and its ability to facilitate agonist-induced plasma membrane localisation of sphingosine kinase 1 (SK1 (show SPHK1 ELISA Kits)), a location where SK1 is known to elicit oncogenic signalling.
a large subset of TNBCs depend on CIB1 for cell survival and tumor growth, independent of CIB1 expression levels.
mRNA and protein expression levels of CIB1 were decreased in the oligoasthenozoospermia patients.CIB1 may be involved in the pathogenesis of oligoasthenozoospermia by the CDK1 (show CDK1 ELISA Kits) signaling pathway.
High serum CIB1 levels are associated with pancreatic cancer.s
KIP binding to TRF2 (show TERF2 ELISA Kits) enhances the telomere-binding activity of TRF2 (show TERF2 ELISA Kits), suggesting that KIP acts as a positive regulator of TRF2 (show TERF2 ELISA Kits) function.
these studies suggested that Kaposi's sarcoma-associated herpesvirus utilizes CIB1 as one of the key molecule(s) to coordinate and sustain the EphA2 (show EPHA2 ELISA Kits) mediated signaling involved in its entry
CIB1a is a novel mediator of PKD2 (show PKD2 ELISA Kits)-driven carcinogenesis.
results suggest that interaction of CIB1 with alphaIIb is one of the early events occurring during outside-in signaling. Furthermore, CIB1 recruits FAK to the alphaIIbbeta3 complex at the filopodia where FAK is activated, which in turn activates c-Src, resulting in propagation of outside-in signaling leading to platelet spreading.
CIB1 is involved in regulating endomitosis, perhaps through its interaction with Polo-like kinase 3 (show PLK3 ELISA Kits)
Data demonstrate that CIB1 is not required for AID to mediate antibody gene diversification processes. It remains possible that CIB1 has an alternative, a redundant or a subtle non-limiting regulatory role in AID biology.
CIB1 functions as a previously undescribed regulator of cardiac hypertrophy through its ability to regulate the association of calcineurin with the sarcolemma and its activation.
CIB1 is a key regulator of thrombosis, by affecting platelet spreading, but not platelet filopodia formation.
CIB co-immunoprecipitated with Snk and inhibited the kinase activity of Snk, suggesting that CIB is a negative regulator for Snk kinase activity.
MEFs derived from Cib1(-/-) mice exhibit a much slower growth rate compared to Cib1(+/+) MEFs, suggesting that CIB1 regulates the cell cycle, differentiation of spermatogenic germ cells, and/or differentiation of supporting Sertoli cells.
loss of CIB1 in endothelial cells decreases p21-activated kinase 1 (show PAK1 ELISA Kits) activation, downstream extracellular signal-regulated kinase 1/2 (show MAPK3 ELISA Kits) activation, and matrix metalloproteinase 2 (show MMP2 ELISA Kits) expression, all of which are known to contribute to angiogenesis.
This gene encodes a member of the EF-hand domain-containing calcium-binding superfamily. The encoded protein interacts with many other proteins, including the platelet integrin alpha-IIb-beta-3, DNA-dependent protein kinase, presenilin-2, focal adhesion kinase, p21 activated kinase, and protein kinase D. The encoded protein may be involved in cell survival and proliferation, and is associated with several disease states including cancer and Alzheimer's disease. Alternative splicing results in multiple transcript variants.
calcium and integrin-binding protein 1
, calcium and integrin binding protein 1
, Calcium and integrin-binding protein 1
, DNA-PK interaction protein
, DNA-PKcs-interacting protein
, DNA-dependent protein kinase interacting protein
, SNK-interacting protein 2-28
, calcium and integrin binding, protein kinase interacting protein
, kinase-interacting protein
, protein kinase, DNA activated, catalytic polypeptide interacting protein
, calcium- and integrin-binding protein