anti-Calpastatin (CAST) Antibodies

The protein encoded by CAST is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. Additionally we are shipping Calpastatin Kits (18) and Calpastatin Proteins (10) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CAST 831 P20810
CAST 12380  
CAST 25403 P27321
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Top anti-Calpastatin Antibodies at

Showing 10 out of 86 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC (p), WB   100 μg Log in to see 4 to 6 Days
Human Rabbit Un-conjugated IHC (p), WB WB Image Sample (30 ug of whole cell lysate) A: A549 7.5% SDS PAGE antibody diluted at 1:2000 IHC-P Image Calpastatin antibody detects Calpastatin protein at cytoplasm in human lung cancer by immunohistochemical analysis. Sample: Paraffin-embedded human lung cancer. Calpastatin antibody , diluted at 1:500. 100 μL Log in to see 1 to 2 Days
Cow Mouse Un-conjugated ICC, IF, IHC (p), IHC, WB Immunohistochemistry-Paraffin: Calpastatin Antibody (1F7E3D10) [ABIN267335] - Both normal and cancer biopsies of deparaffinized Human breast carcinoma tissues. Immunohistochemistry-Paraffin: Calpastatin Antibody (1F7E3D10) [ABIN267335] - Both normal and cancer biopsies of deparaffinized Human tonsil tissues. 0.1 mL Log in to see 7 to 9 Days
Human Rabbit Un-conjugated FACS, IF (p), IHC (p) Mouse spleen cells probed with Rabbit Anti-Calpastatin Polyclonal Antibody, PE Conjugated at 1:50 for 30 minutes. 100 μL Log in to see 3 to 7 Days
Human Rabbit Un-conjugated IF, IHC, WB 100 μL Log in to see 16 Days
Human Rabbit Un-conjugated IHC (p), WB 100 μL Log in to see 7 to 9 Days
Human Mouse Un-conjugated FACS, IHC, WB HEK293T cells transfected with either RC211776 overexpress plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-CAST antibody (ABIN2455597), and then analyzed by flow cytometry. HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CAST (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-CAST. 100 μL Log in to see 2 to 3 Days
Human Mouse Un-conjugated IF, ELISA, WB CAST monoclonal antibody (M03), clone 2C5. Western Blot analysis of CAST expression in NIH/3T3 . Detection limit for recombinant GST tagged CAST is 0.03 ng/ml as a capture antibody. 100 μg Log in to see 11 to 12 Days
Cow Mouse Un-conjugated ICC, IHC, IHC (fro), IHC (p), WB Immunohistochemistry-Paraffin: Calpastatin Antibody (2G11D6) [ABIN267178] - Biopsies of deparaffinized Human skeletal muscle tissue. Immunohistochemistry-Paraffin: Calpastatin Antibody (2G11D6) [ABIN267178] - Cancer biopsies of deparaffinized Human breast carcinoma tissue. 0.1 mL Log in to see 7 to 9 Days
Human Rabbit PE FACS   100 μL Log in to see 3 to 7 Days

CAST Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Calpastatin Antibodies

  1. Human Polyclonal Calpastatin Primary Antibody for FACS, IF (p) - ABIN720161 : Huang, Rose, Hoffmann, Hashimoto, Bertino, Denk, Takano, Iwata, Saido, Hoffmann: Calpastatin prevents NF-?B-mediated hyperactivation of macrophages and attenuates colitis. in Journal of immunology (Baltimore, Md. : 1950) 2013 (PubMed)

  2. Cow (Bovine) Monoclonal Calpastatin Primary Antibody for ICC, IF - ABIN267335 : Kaur, Mencl, Sahaboglu, Farinelli, van Veen, Zrenner, Ekström, Paquet-Durand, Arango-Gonzalez: Calpain and PARP activation during photoreceptor cell death in P23H and S334ter rhodopsin mutant rats. in PLoS ONE 2011 (PubMed)

  3. Cow (Bovine) Monoclonal Calpastatin Primary Antibody for ICC, WB - ABIN283976 : Zór, Castellarnau, Pascual, Pich, Plasencia, Bardsley, Nistor: Design, development and application of a bioelectrochemical detection system for meat tenderness prediction. in Biosensors & bioelectronics 2011 (PubMed)

More Antibodies against Calpastatin Interaction Partners

Human Calpastatin (CAST) interaction partners

  1. single nucleotide polymorphisms in CAST gene confer risk for keratoconus susceptibility in Han Chinese population

  2. Kaposi sarcoma-associated herpesvirus reduces CAST (calpastatin) and consequently decreases ATG5 (show ATG5 Antibodies) expression in both THP-1 (show GLI2 Antibodies) monocytoid cells and primary monocytes.

  3. calpains and calpastatin in patients with idiopathic pulmonary arterial hypertension (PAH) and mice with hypoxic or spontaneous (SM22 (show TAGLN Antibodies)-5HTT (show SLC6A4 Antibodies)(+) strain) PH, were investigated.

  4. Loss of CAST in angiogenic ECs facilitates mu (show JAK3 Antibodies)-calp (show STAT1 Antibodies)ain-induced SOCS3 degradati (show SOCS3 Antibodies)on, which amplifies p (show VEGFC Antibodies)athological angiogenesis through interleukin-6/STAT3/VEGF-C axis.

  5. We describe PLACK syndrome, as a clinical entity of defective epidermal adhesion, caused by loss-of-function mutations in calpastatin.

  6. Calpastatin binds with Cav1.2 (show CACNA1C Antibodies) amino acid motifs in a calcium dependent manner.

  7. Calpastatin gene (CAST) is not associated with late onset sporadic Parkinson's disease in the Han Chinese population.

  8. HER2 (show ERBB2 Antibodies) inhibited calpain-1 (show CAPN1 Antibodies) activity through upregulating calpastatin, an endogenous calpain inhibitor.

  9. The results suggest that calpain-2 (show CAPN2 Antibodies) and calpastatin expression is important in pancreatic cancers, influencing disease progression

  10. Neuronal overexpression of calpastatin modulates amyloid precursor protein (show APP Antibodies) processing in brains of transgenic beta-amyloid depositing mice.

Mouse (Murine) Calpastatin (CAST) interaction partners

  1. calpains and calpastatin in patients with idiopathic pulmonary arterial hypertension (PAH) and mice with hypoxic or spontaneous (SM22 (show TAGLN Antibodies)-5HTT (show SLC6A4 Antibodies)(+) strain) PH, were investigated.

  2. Defective scar formation after myocardial infarction in calpastatin transgenic mice was associated with blunted CD4 (show CD4 Antibodies)(+) T-cell and M2-macrophage recruitment.

  3. Over-expression of Cast inhibits calpain activation and attenuates post-infarction myocardial remodeling.

  4. EC-specific transgenic CAST downregulated JAK (show JAK3 Antibodies)/STAT (show STAT1 Antibodies) signals, upregulated SOCS3 (show SOCS3 Antibodies), and depleted VEGF-C (show VEGFC Antibodies), counteracting unstable pathological neovessels and disease progression in tumors and oxygen-induced retinopathy lesions in mice.

  5. Overexpression of the calpain-specific inhibitor calpastatin reduces human alpha-synuclein processing, aggregation and synaptic impairment in transgenic mice.

  6. We observed that ischemia induction results in increased expression of CaN, Calp (show KCNIP4 Antibodies) and Calpn.

  7. Over-expression of calpastatin enhances doxorubicin-induced cardiac injuries through calpain inhibition.

  8. The calpain/calpastatin system has opposing roles in growth and metastatic dissemination of melanoma.

  9. Data show that genetic deficiency of calpastatin (CS) augmented Abeta (show APP Antibodies) amyloidosis, tau phosphorylation, microgliosis, and somatodendritic dystrophy, and increased mortality in amyloid precursor protein (APP (show APP Antibodies)) transgenic mice.

  10. PIN1 apparently restrains the ability of calpastatin to inhibit calpain, maintaining calpain activity in endothelial cells.

Cow (Bovine) Calpastatin (CAST) interaction partners

  1. The calpastatin gene (CAST), which is located on bovine chromosome 7 (BTAU7), is considered a strong functional candidate for meat tenderness in livestock species.

  2. The suppression of calpastatin resulted in the increased expression of mu-calpain (show CAPNL1 Antibodies), caspases, and HSPs which in turn regulate apoptotic cell death.

  3. This work is supportive of the importance of CAPN1 (show CAPNL1 Antibodies) and CAST for mean tenderness in beef.

  4. bovine CAPN-CAST interaction were well reflected in the geometry between the pharmacophore features and its shape constraints identified using our modeled bovine CAPN1 (show CAPNL1 Antibodies)/CAST4 complex structures

  5. CAST binds and inhibits CAPN via its CAPN-inhibitor domains(CAST1 (show ERC2 Antibodies)-4) .CAST4 docks near the flexible active site of CAPN1 (show CAPNL1 Antibodies), conformational changes at the interaction site after binding could be directly related to CAST4 inhibitory activity.

  6. This work confirms the importance of CAPN1 (show CAPNL1 Antibodies) and CAST for tenderness in beef, provides a new effect of CAST on beef tenderness, and questions the utility of GHR (show GHR Antibodies) as a selection marker for beef quality.

  7. The association of single nucleotide polymorphisms in calpastatin with muscle tenderness was studied.

  8. Association of polymorphisms in calpain 1 (show CAPN1 Antibodies), (mu/I) large subunit, calpastatin, and cathepsin D (show CTSD Antibodies) genes with meat quality traits in double-muscled Piemontese cattle.

  9. The CAST28 genotypes showing allele frequencies of C (0.429) and T (0.571) were significantly associated with calpastatin activity and Warner-Bratzler Shear Force in beef.

  10. The association of polymorphisms in calpastatin and mu-calpain (show CAPNL1 Antibodies) genes with meat tenderness in 3 French beef breeds is reported.

Pig (Porcine) Calpastatin (CAST) interaction partners

  1. CT1 (show SLC6A8 Antibodies) decreases cell death through a mechanism related to Stat3 (show STAT3 Antibodies) and Akt (show AKT1 Antibodies) phosphorylation and activation of calpastatin in D-galactosamine-treated hepatocytes.

  2. CAST gene affected post-mortem activation time of calpain and drip loss.

  3. The quality of meat influenced by RYR1 (show RYR1 Antibodies) genotype may be modified by the simultaneous influence of genotype as regards the CAST locus

  4. The effect of the beta-adrenergic agonist clenbuterol and porcine ST (pST (show SULT1A1 Antibodies)) treatment on calpastatin promoter usage in vivo and in vitro are reported.

  5. The Decreased expression of calpastatin mRNA during development is highly correlated with muscle protein accumulation in neonatal Sus scrofa.

Calpastatin (CAST) Antigen Profile

Protein Summary

The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Alternatively spliced transcript variants encoding different isoforms have been described.

Gene names and symbols associated with anti-Calpastatin (CAST) Antibodies

  • calpastatin (CAST) antibody
  • calpastatin (Cast) antibody
  • calpastatin S homeolog (cast.S) antibody
  • calpastatin (cast) antibody
  • calpastatin (VDBG_09182) antibody
  • Calpastatin (ical) antibody
  • BS-17 antibody
  • calp3 antibody
  • cast antibody
  • DKFZp469E0716 antibody
  • sb:cb966 antibody
  • zgc:194249 antibody

Protein level used designations for anti-Calpastatin (CAST) Antibodies

calpain inhibitor , sperm BS-17 component , calpastatin type III , calpastatin isoform III , calpastatin type I , calpastatin type II , calpastatin , Calpastatin , calpastatin-like

831 Homo sapiens
12380 Mus musculus
25403 Rattus norvegicus
281039 Bos taurus
397135 Sus scrofa
398115 Xenopus laevis
427121 Gallus gallus
443364 Ovis aries
462348 Pan troglodytes
479148 Canis lupus familiaris
563084 Danio rerio
703623 Macaca mulatta
9528399 Verticillium alfalfae VaMs.102
100009098 Oryctolagus cuniculus
100073225 Equus caballus
100136674 Oncorhynchus mykiss
100145371 Xenopus (Silurana) tropicalis
100174647 Pongo abelii
100380407 Salmo salar
100391897 Callithrix jacchus
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