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CMBL (EC 18.104.22.168) is a cysteine hydrolase of the dienelactone hydrolase family that is highly expressed in liver cytosol. Additionally we are shipping CMBL Antibodies (34) and CMBL Proteins (9) and many more products for this protein.
By comparing the enzyme kinetics and chemical inhibition properties between the recombinant protein and tissue preparations, CMBL was shown to be the primary olmesartan medoxomil bioactivating enzyme in the liver and intestine.
CMBL (EC 22.214.171.124) is a cysteine hydrolase of the dienelactone hydrolase family that is highly expressed in liver cytosol. CMBL preferentially cleaves cyclic esters, and it activates medoxomil-ester prodrugs in which the medoxomil moiety is linked to an oxygen atom (Ishizuka et al., 2010
, carboxymethylenebutenolidase-like (Pseudomonas)
, liver regeneration-related protein LRRG072