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In case of murine coronavirus (MHV) infection, does probably not serve as functional receptor for the virus..
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disruption of CEACAM2 induces a moderate integrin alphaIIbbeta3-mediated platelet function defect, and that CEACAM2 is essential to maintain a normal integrin alphaIIbbeta3-mediated platelet function.
CEACAM2 regulates insulin (show INS Antibodies) secretion, at least in part, by a GLP-1 (show GCG Antibodies)-mediated mechanism, independent of confounding metabolic factors.
Functional studies of platelets from Ceacam2(-/-)-deficient mice (Cc2 (show TSG101 Antibodies)(-/-)) revealed that CEACAM2 serves to negatively regulate collagen glycoprotein VI (platelet) (GPVI (show GP6 Antibodies))-FcRgamma (show FCER1G Antibodies)-chain and the C-type lectinlike receptor 2 (CLEC-2 (show CLEC1B Antibodies)) signaling
Sertoli cells recognize the excess cytoplasm of elongated spermatids through the PVR (show PVRL2 Antibodies)-CEACAM2-L interaction in mouse testis
CEACAM2-L might be a novel adhesion molecule (show NCAM1 Antibodies) contributing to cell-to-cell adhesion between elongating spermatids and Sertoli cells within the seminiferous epithelium
Data suggest that CEACAM2 has a role in regulation of metabolic rate and insulin (show INS Antibodies) sensitivity/resistance via effects on brown adipogenesis, sympathetic nervous outflow to brown adipose tissue, and energy expenditure in skeletal muscle.
In case of murine coronavirus (MHV) infection, does probably not serve as functional receptor for the virus.
, CEA-related cell adhesion molecule 2
, biliary glycoprotein 2
, carcinoembryonic antigen-related cell adhesion molecule 2- Long