Cartilage Oligomeric Matrix Protein Proteins (COMP)

The protein encoded by COMP is a noncollagenous extracellular matrix (ECM) protein. Additionally we are shipping COMP Antibodies (130) and COMP Kits (81) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
COMP 25304 P35444
COMP 1311 P49747
COMP 12845 Q9R0G6
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Top COMP Proteins at antibodies-online.com

Showing 10 out of 22 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Human Cells Human His tag 100 μg Log in to see 14 to 16 Days
€338.76
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
€12,160.77
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
€12,160.77
Details
HEK-293 Cells Human His tag 50 μg Log in to see 2 to 3 Days
€544.25
Details
Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 15 to 18 Days
€589.38
Details
Escherichia coli (E. coli) Rat His tag 100 μg Log in to see 15 to 18 Days
€625.66
Details
HEK-293 Cells Human His tag Human COMP, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 88%. 100 μg Log in to see 2 to 3 Days
€243.36
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
€484.78
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
€3,673.16
Details
HEK-293 Cells Human His tag   0.1 mg Log in to see 2 to 3 Days
€456.31
Details

COMP Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus) ,

Human , , ,
, ,
Mouse (Murine) ,

Top referenced COMP Proteins

  1. Rat (Rattus) COMP Protein expressed in - ABIN1047991 : Spitznagel, Nitsche, Paulsson, Maurer, Zaucke: Characterization of a pseudoachondroplasia-associated mutation (His587-->Arg) in the C-terminal, collagen-binding domain of cartilage oligomeric matrix protein (COMP). in The Biochemical journal 2004 (PubMed)

More Proteins for Cartilage Oligomeric Matrix Protein (COMP) Interaction Partners

Horse (Equine) Cartilage Oligomeric Matrix Protein (COMP) interaction partners

  1. The aims of this study were to investigate the proteomic composition of injured tendons during early and late disease stages to identify disease-specific cleavage patterns of the extracellular matrix protein cartilage oligomeric matrix protein (COMP).

  2. The present results suggest that not only type III collagen but also cartilage oligomeric matrix protein is involved in the repair and remodeling processes of the digital flexor tendon.

  3. Within the limitations of the study design, production of COMP during healing of skin wounds does not appear to be influenced by wound type or anatomic site, nor does it appear to be correlated with TGF-beta1 concentrations.

  4. COMP concentrations in digital flexor tendon sheath synovial fluid were significantly greater than those in normal horses with noninfected tenosynovitis caused by intrathecal tendon/ligament tearing, but not by other lesions.

  5. The present study indicates that dynamic in vivo compression at high load and frequency lowers matrix content of COMP in the articular cartilage of the third carpal bone.

Human Cartilage Oligomeric Matrix Protein (COMP) interaction partners

  1. Adolescent idiopathic scoliosis patients had significantly high COMP promoter methylation and low gene expression. Positive and high COMP promoter methylation was correlated with young age and high Cobb angle of main curve

  2. Our findings indicated that hepatic stellate cells-derived COMP collaborated with CD36 and subsequently played an essential role in MEK/ERK and PI3K/AKT-mediated hepatocellular carcinoma (HCC) progression. COMP might act as a promising target for the diagnosis and treatment of aggressive HCC.

  3. These findings suggest that Zalpha domain of human ADAR1 binding with the GAC hairpin stem in COMP can lead to a non-genetic, RNA editing-mediated substitution in COMP that may then play a crucial role in the development of pseudoachondroplasia.

  4. Higher serum COMP levels in knee osteoarthritis reflect knee structural damage.

  5. COMP (and C-reactive protein) serum levels were both associated with the incidence of knee osteoarthritis.

  6. Data indicate cartilage oligomeric matrix protein (COMP) homozygote missense variant [c.1423G>A; p.(D475N)] in 2 severely affected pseudoachondroplasia individuals.

  7. The serum COMP is a promising biomarker in rheumatoid arthritis which reflects disease activity and damage to the articular cartilage.

  8. the novel mutation of COMP may result in intracellular accumulation of the mutant protein. Decreased plasma COMP and increased plasma CTX-II may potentially serve as diagnostic markers of PSACH but may not be applicable in the presymptomatic carrier.

  9. COMP promoted colon cancer cell proliferation partially through the activation of PI3K/ Akt/ mTOR/ p70S6K pathway.

  10. The findings suggest that upregulation of ADAMTS-7 and down regulation of COMP are associated with human AA.

  11. Data show that a rare missense variant in the COMP gene (cartilage oligomeric matrix protein) and a frameshift variant in the CHADL gene (chondroadherin-like protein) strongly associate with osteoarthritis total hip replacement.

  12. COMP is a novel biomarker in breast cancer, which contributes to the severity of the disease by metabolic switching and increasing invasiveness and tumor cell viability, leading to reduced survival in animal models and human patients.

  13. The average sCOMP level was highest among the controls and lowest among the infected children. In the juvenile idiopathic arthritis patients, the level of sCOMP was not associated with the level of CRP or with clinical signs of disease activity.

  14. COMT Val158Met polymorphism may influence responses to dextromethorphan (30 mg/d) by decreasing depressive symptoms in BD patients.

  15. The serum COMP level has the potential to be used as a biological marker for differentiating between patients with rheumatoid arthritis and healthy individuals.

  16. The current study expanded the mutation spectrum of the COMP gene, and contributes to the understanding of phenotype/genotype of COMPassociated diseases.

  17. In the absence of ultrasonographic knee cartilage deformation, the response of serum lubricin and COMP following acute vigorous exercise indicates an increase in joint lubrication and cartilage metabolism, respectively, which appears largely independent of exercise modality.

  18. Running appears to decrease knee intra-articular pro-inflammatory cytokine concentration and facilitates the movement of COMP from the joint space to the serum.

  19. Results suggest that serum oligomeric matrix protein and hyaluronic acid (COMP and HA) concentrations can be used to predict early cartilage lesions in the knee.

  20. Serum COMP levels are predictive of subsequent structural changes and incidence of painful knee osteoarthritis.

Mouse (Murine) Cartilage Oligomeric Matrix Protein (COMP) interaction partners

  1. COMP could normally have a protective role against PASMC phenotype switching

  2. these findings revealed the essential role of COMP in retarding the development of vascular aging and vascular smooth muscle cell senescence.

  3. COMP deficiency drove macrophages toward the atherogenic phenotype and thereby aggravated atherosclerotic calcification.

  4. COMP forms a complex with collagens intracellularly that is a prerequisite for collagen secretion.

  5. The accumulation and thereby the functionality of thrombospondin in extracellular matrix is controlled by concentration-dependent, intermolecular "matrix trapping" mechanism.

  6. COMP-Ang1 can enhance BMP2-induced cranial bone regeneration with increased pericyte recruitment. Combined delivery of the proteins might be a therapeutic strategy to repair cranial bone damage.

  7. COMP deficiency shortened tail-bleeding and clotting time and accelerated ferric-chloride-induced thrombosis. COMP specifically inhibited thrombin-induced platelet aggregation, activation, and retraction and the thrombin-mediated cleavage of fibrinogen.

  8. COMP immunoreactivity was observed in about half of the investigated plaques from the ApoE null mice, mainly located along the intima-medial border. Plaques in the brachiocephalic artery from ApoE mice lacking COMP were increased in size with 54%.

  9. study will facilitate better awareness of the differential diagnoses that might be associated with the PSACH/MED spectrum and subsequent care of PSACH/MED patients

  10. The lack of arthritis, together with high levels of COMP-specific antibodies, in COMP-deficient mice indicates that susceptibility to arthritis is COMP specific and that endogenous expression of COMP in wild-type mice tolerizes B cells in vivo.

  11. results imply that COMP is not a key upstream mediator of the anabolic effects of ML on the skeleton.

  12. Lack of COMP and matrilin 3 leads to increased deposition of TIMP-3, which causes partial inactivation of matrix metalloproteinases in bone, including MMP-13.

  13. A novel form of chondrocyte stress triggered by the expression of a human-like mutation in COMP is central to the pathogenesis of pseudoachondroplasia.

  14. reducing steady state levels of COMP mRNA alleviates intracellular retention of other extracellular matrix proteins associated with the pseudoachondroplasia cellular pathology

  15. Data show that cartilage oligomeric matrix protein (COMP) promotes cell attachment via independent mechanisms involving cell surface CD47 and alphaVbeta3 integrin and that cell attachment to COMP induces formation of fascin-stabilized actin microspikes.

  16. Loss of type IX collagen and COMP leads to matrix aberrations that may make cartilage more susceptible to degeneration.

  17. Cartilage oligomeric matrix protein-deficient mice have normal skeletal development.

  18. Comp was expressed in tendon clone cells.

  19. Negative regulation of transcription is an important mechanism for chondrocyte-specific expression of the COMP gene

  20. ADAMTS-7 is the first metalloproteinase found to bind directly to and degrade COMP

Cow (Bovine) Cartilage Oligomeric Matrix Protein (COMP) interaction partners

  1. COMP synthesis is differentially regulated by TGFbeta1 in the surface and middle zones of bovine articular cartilage.

  2. role for proteinases other than MMPs in the degradation of COMP in cartilage

  3. COMP mutant expression in tendon fibroblasts leads to increased apoptotic cell death irrespective of the secretory characteristics of mutant COMP

  4. COMP mRNA expression level was markedly increased by ball oscillation.

  5. COMP acts as a catalyst in collagen fibrillogenesis.

COMP Protein Profile

Protein Summary

The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Mutations can cause the osteochondrodysplasias pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED).

Gene names and symbols associated with COMP

  • cartilage oligomeric matrix protein (COMP)
  • cartilage oligomeric matrix protein (sce3551)
  • cartilage oligomeric matrix protein (CJA_1292)
  • cartilage oligomeric matrix protein (Comp)
  • COMP protein
  • EDM1 protein
  • EPD1 protein
  • MED protein
  • PSACH protein
  • THBS5 protein
  • TSP5 protein

Protein level used designations for COMP

cartilage oligomeric matrix protein , TSP5 , cartilage oligomeric matrix protein (pseudoachondroplasia, epiphyseal dysplasia 1, multiple) , cartilage oligomeric matrix protein(pseudoachondroplasia, epiphyseal dysplasia 1, multiple) , pseudoachondroplasia (epiphyseal dysplasia 1, multiple) , thrombospondin-5 , putative cartilage oligomeric matrix protein

GENE ID SPECIES
469068 Pan troglodytes
5808591 Sorangium cellulosum So ce56
6415089 Cellvibrio japonicus Ueda107
100033911 Equus caballus
25304 Rattus norvegicus
1311 Homo sapiens
12845 Mus musculus
281088 Bos taurus
100720040 Cavia porcellus
396554 Sus scrofa
476665 Canis lupus familiaris
420120 Gallus gallus
101107864 Ovis aries
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