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CSNK2B encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication.
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a functional analysis using rBmCK2alpha and beta subunits of Drosophila melanogaster CK2 (show CSNK2A1 Antibodies) revealed that a difference in the C-terminal amino acid of the CK2beta subunit influenced the phosphorylation activity of rBmCK2alpha.
Patients described are the first cases presenting a loss-of-function variant in the CSNK2B gene in the context of intellectual disability (ID), suggesting that CSNK2Bvariants can cause ID.
ALMS1, (show GLT8D1 Antibodies) GLT8D1, and CSNK2B are schizophrenia risk genes.
CK2 (show CSNK2A1 Antibodies) is required to mediate FXR (show NR1H4 Antibodies) SUMOylation.
We report interactions between CSNK (show CSN3 Antibodies)-2beta and IGFBP-1 (show IGFBPI Antibodies) as well as mTOR (show FRAP1 Antibodies) and CSNK (show CSN3 Antibodies)-2beta, providing strong evidence of a mechanistic link between mTOR (show FRAP1 Antibodies) and IGF-I (show IGF1 Antibodies) signaling, two critical regulators of cell growth via CSNK (show CSN3 Antibodies)-2.
The lack of intermediate species of CK2 (show CSNK2A1 Antibodies) alpha2beta2 in solution suggests that the holoenzyme is a strong/stable multimeric complex that does not spontaneously dissociate; a considerable amount of monomer, the active form of CK2 (show CSNK2A1 Antibodies), is present in low ionic strength solutions. Multimer assembly appears driven by electrostatic interactions between the CK2alpha P+1 loop and the CK2beta acidic loop.
These data support a role for casein kinase 2 in regulation of protein synthesis by downregulating stress granule formation through G3BP1 (show G3BP1 Antibodies).
Casein kinase 2 role in the proliferation of human osteosarcoma cells.
Data suggest that cryptochromes mediate periodic binding of Ck2b (casein kinase 2beta) to Bmal1 (aryl hydrocarbon receptor nuclear translocator-like (show ARNTL Antibodies) protein) and thus inhibit Bmal1 (show ARNTL Antibodies)-Ser90 phosphorylation by Ck2a (show CSNK2A1 Antibodies) (casein kinase 2alpha). [SYNOPSIS]
Data suggest that cryptochromes (Cry1 (show CRY1 Antibodies) and Cry2 (show CRY2 Antibodies)) mediate periodic binding of Ck2b (casein kinase 2beta) to Bmal1 (aryl hydrocarbon receptor nuclear translocator-like (show ARNTL Antibodies) protein) and thus inhibit Bmal1 (show ARNTL Antibodies)-Ser90 phosphorylation by Ck2a (show CSNK2A1 Antibodies) (casein kinase 2alpha).
AMPKalpha (show GRK4 Antibodies) signalling suppresses EMT (show ITK Antibodies) and secretion of chemokines in renal tubular epithelia through interaction with CK2beta to attenuate renal injury.
GLT8D1 (show GLT8D1 Antibodies) and CSNK2B knockdown promote the proliferation and inhibit the differentiation abilities of neural stem cells, and alter morphology and synaptic transmission of mouse neurons.
thrombotic vascular occlusion in vivo was significantly blunted in ck2beta(-/-) mice, accompanied by a slight prolongation of bleeding time
These data suggest that CK2 is a negative regulator of BMP signaling and osteoblast differentiation.
Data suggest that CK2beta appears to play an essential and uncompensated role in central nervous system development.
Data show that casein kinase 2beta interacts specifically with Tctex4 both in a yeast two-hybrid system and in an in vitro interaction assay.
there is a functional link between S6K1 (show RPS6KB1 Antibodies) II and CK2 (show CSNK2A1 Antibodies) signaling, which involves the regulation of S6K1 (show RPS6KB1 Antibodies) II nuclear export by CK2 (show CSNK2A1 Antibodies)-mediated phosphorylation of Ser (show SIGLEC1 Antibodies)-17
CK2 (show CSNK2A1 Antibodies) can inhibit G protein-coupled receptor (show GPR34 Antibodies) action by enabling faster receptor internalization, possibly through a direct association with Galpha (show SUCLG1 Antibodies)(s)
These data demonstrate that BoHV-1 VP22 interacts with both CK2 (show CSNK2A1 Antibodies) and US3, and that CK2 (show CSNK2A1 Antibodies) is the major kinase phosphorylating VP22, with US3 playing a minor role.
CK2 (show CSNK2A1 Antibodies)-activated phosphorylation cascade controlling PACS-1 (show PACS1 Antibodies)- and GGA3 (show GGA3 Antibodies)-mediated CI-MPR (show IGF2R Antibodies) sorting, is reported.
The CK2alpha/beta complex stimulates Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signalling, and the physical interaction of CK2beta with PAPC (show PCDH8 Antibodies) antagonizes this activity.
Structure of the regulatory subunit of CK2 in the presence of a p21WAF1 peptide
This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme is composed of three subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic, while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus.
casein kinase 2 beta subunit
, CK II beta
, casein kinase II subunit beta
, Casein kinase II beta subunit
, alternative name: G5a, phosvitin
, protein G5a
, casein kinase II, beta subunit
, Csnk2b splicing isoform 662
, casein kinase 2, beta subunit
, casein kinase II beta subunit
, casein kinase II b subunit splicing isoform 666
, casein kinase II b subunit splicing isoform 663
, chimera Csnk2b-Ly6g5b splicing isoform 1239
, Beta subunit of casein kinase II