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The protein encoded by CHL1 is a member of the L1 gene family of neural cell adhesion molecules.
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Results indicate that close homolog of L1 protein (CHL1) is downregulated by hypermethylation and that this epigenetic alteration is an independent prognostic factor in breast cancer (BC).
CHL1 expression patient-derived lymphoblasts correlated with clinical outcome in depressive disorder patients.
our findings suggest that miR-590-5p acts as an oncogene by targeting the CHL1 gene and promotes cervical cancer proliferation
There was no statistical association between polymorphisms of the CHL1 gene and idiopathic scoliosis in a Chinese population.
Our data collectively indicate that miR (show MLXIP Antibodies)-182 in PTC (show F9 Antibodies) promotes cell proliferation and invasion through direct suppression of CHL1 (show DDX11 Antibodies), supporting the potential utility of miR (show MLXIP Antibodies)-182 inhibition as a novel therapeutic strategy against PTC (show F9 Antibodies).
The rs2272522 polymorphism (in the CHL1 gene) was found to exhibit a highly significant association with schizophrenia in the Qatari population.
In 1 of 113 Colombian children with refractory epilepsy, MLPA showed a subtelomeric duplication of exon 3 of CHL1, also present in 2 relatives.
CHL1 has a role in human breast tumorigenesis and progression
The miRNA miR (show MLXIP Antibodies)-151-3p had 6.7-fold higher basal expression in paroxetine-sensitive LCLs. This corresponds with lower expression of CHL1 (show DDX11 Antibodies), a target of miR (show MLXIP Antibodies)-151-3p
BACE1(-/-) axon guidance defects are likely the result of abrogated BACE1 processing of CHL1 and BACE1 deficiency produces a CHL1 loss-of-function phenotype
The protein encoded by this gene is a member of the L1 gene family of neural cell adhesion molecules. It is a neural recognition molecule that may be involved in signal transduction pathways. The deletion of one copy of this gene may be responsible for mental defects in patients with 3p- syndrome. This protein may also play a role in the growth of certain cancers. Alternate splicing results in both coding and non-coding variants.
L1 cell adhesion molecule 2
, cell adhesion molecule with homology to L1CAM (close homolog of L1)
, cell adhesion molecule with homology to L1CAM (close homologue of L1)
, close homolog of L1
, neural cell adhesion molecule L1-like protein