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CIDEC encodes a member of the cell death-inducing DNA fragmentation factor-like effector family. Additionally we are shipping CIDEC Antibodies (99) and CIDEC Proteins (8) and many more products for this protein.
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CIDEC may affect body measurement traits and meat quality traits in Qinchuan cattle, and could be used in marker-assisted selection.
This paper examined the tissue expression profile of CIDEC gene in cattle.
FTO (show FTO ELISA Kits) increased the lipid accumulation in hepatocytes by increasing nuclear translocation of SREBP1c (show SREBF1 ELISA Kits) and SREBP1c (show SREBF1 ELISA Kits) maturation, thus improving the transcriptional activity of lipid droplet-associated protein (show PLIN1 ELISA Kits) CIDEC.
this study has indicated that 3' UTR (show UTS2R ELISA Kits) variation in CIDEC is associated with the risk of elevated fasting glucose, the progression of hypertriglyceridemia and hypertension, and the efficacy of angiotensin II-targeted antihypertensive agents.
Two tissue-specific CIDEc isoforms had different roles in lipid deposition.
data suggested that Cidec could interact with and down-regulate AMPKalpha through an ubiquitin-proteasome degradation pathway, which provided a possible mechanism of Cidec in promoting human adipocytes differentiation
Hepatic expression of FSP27/CIDEC is highly up-regulated in in patients with alcoholic steatohepatitis and this up-regulation contributes to alcohol-induced liver damage.
It is insinuated that VAT is associated with late phase obesity CIDEC decrease and insulin (show INS ELISA Kits) resistance, while pioglitazone enhances CIDEC through activation of PPAR-gamma (show PPARG ELISA Kits), increases its expression, and decreases lipolysis.
After bariatric surgery-induced weight loss, CIDEC/FSP27 gene/protein expression in SAT increased significantly. Findings suggest a positive functional interaction between CIDEC/FSP27 & mitochondrial biogenesis-related genes in human adipose tissue
Data indicate that fat-specific protein 27 (FSP27) increases the inhibitory effect of transcription factor Egr1 (show EGR1 ELISA Kits) on the adipose triglyceride lipase (ATGL (show PNPLA2 ELISA Kits)) promoter.
results demonstrate a crucial role for FSP27-ATGL (show PNPLA2 ELISA Kits) interactions in regulating lipolysis, triglyceride accumulation, and insulin (show INS ELISA Kits) signaling in human adipocytes
homo-dimeric structure of the CIDE-N domain of FSP27 will provide important information that will enable better understanding of the function of FSP27.
the role of gp78 (show AMFR ELISA Kits) and cidec in hepatic steatosis, were investigated.
The current study demonstrated that insulin (show INS ELISA Kits) represses fasting-induced Fsp27 expression in the liver. The Fsp27 decreased by insulin (show INS ELISA Kits) is likely to cause the lower fat accumulation in liver.
Fatty acids prevent CIDEC deacetylation by promoting the dissociation of CIDEC from HDAC6 (show HDAC6 ELISA Kits), resultin in increased association of CIDEC with PCAF (show KAT2B ELISA Kits) on the endoplasmic reticulum.
We show that partial silencing Fsp27 in either model results in the robust decrease in visceral fat, improved insulin (show INS ELISA Kits) sensitivity and whole-body glycemic control, and tissue-specific changes in transcripts controlling lipid oxidation and synthesis
results suggest that FSP27beta negatively regulates CideA-promoted enlargement of lipid droplet size in brown adipocytes.
Lipid droplet (LD) expansion depends on the FSP27 carboxy-terminal domain (amino acids 131-239). The negative charge of acidic residues D215, E218, E219 and E220 in the polar carboxy-terminal region (amino acids 202-239) is essential for LD enlargement.
Data (including data from studies in knockout mice) suggest Cideb promotes lipid storage as droplets in hepatocytes under normal diet conditions; Cidea/Cidec promote fusion of lipid droplets leading to liver steatosis in fasting (16h) and obese mice.
Cidea is highly associated with adiposity and insulin (show INS ELISA Kits) resistance, whereas Cidec is related to insulin (show INS ELISA Kits) sensitivity
Hepatic expression of FSP27/CIDEC is highly up-regulated in mice following chronic-plus-binge ethanol feeding and this up-regulation contributes to alcohol-induced liver damage.
Insulin (show INS ELISA Kits) resistance and white adipose tissue inflammation are uncoupled in energetically challenged Fsp27-deficient mice.
CIDEC protects lipid droplets (LDs) by decreasing the specific surface area of LDs and is involved in the regulation of hepatic lipid deposition.
CIDEa and CIDEc mRNA level in white adipose tissues and liver were significantly higher in obese pigs than in their lean counterparts
This gene encodes a member of the cell death-inducing DNA fragmentation factor-like effector family. Members of this family play important roles in apoptosis. The encoded protein promotes lipid droplet formation in adipocytes and may mediate adipocyte apoptosis. This gene is regulated by insulin and its expression is positively correlated with insulin sensitivity. Mutations in this gene may contribute to insulin resistant diabetes. A pseudogene of this gene is located on the short arm of chromosome 3. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene.
cell death-inducing DFFA-like effector c
, cell death activator CIDE-3
, cell death-inducing DFFA-like effector protein C
, fat-specific protein FSP27 homolog
, Cell death activator CIDE-3
, fat specific protein 27
, fat specific gene 27
, fat-specific protein FSP27
, cell-death-inducing DNA-fragmentation-factor-like effector C