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CENPO encodes a component of the interphase centromere complex.
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Data propose that CENP-P (show CENPP Proteins)/O/R/Q/U self-assembles on kinetochores with varying stoichiometry and undergoes a pre-mitotic maturation step that could be important for kinetochores switching into the correct conformation for microtubule-attachment.
CENP-O protein is a novel centromere antigen that is recognized by a very minor population of ACA-positive patients with scleroderma.
This gene encodes a component of the interphase centromere complex. The encoded protein is localized to the centromere throughout the cell cycle and is required for bipolar spindle assembly, chromosome segregation and checkpoint signaling during mitosis. Alternatively spliced transcript variants encoding multiple protein isoforms have been observed for this gene.
centromere protein O
, centromeric protein O
, interphase centromere complex protein 36