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CSPP1 interacts with centrosomes and microtubules and plays a role in cell-cycle progression and spindle organization (Patzke et al., 2005. Additionally we are shipping and many more products for this protein.
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Cow (Bovine) Polyclonal Cspp1 Primary Antibody for ELISA, WB - ABIN4265162
Patzke, Redick, Warsame, Murga-Zamalloa, Khanna, Doxsey, Stokke: CSPP is a ciliary protein interacting with Nephrocystin 8 and required for cilia formation. in Molecular biology of the cell 2010
Microtubule-independent but desmoplakin (show DSP Antibodies)-dependent localization of CSPP-L to desmosomes occurs in apical-basal polarized epithelial cells. CSPP-L depletion promoted multi-lumen spheroid formation in Caco-2 cells.
propose that CSPP1 cooperates with CENP-H (show CENPH Antibodies) on kinetochores to serve as a novel regulator of kinetochore microtubule dynamics for accurate chromosome segregation
Differential expression of a nuclear CSPP1 isoform identified biologically and clinically distinct subgroups of basal-like breast carcinoma.
mutations in CSPP1 were associated with variable ciliopathy phenotypes ranging from Joubert syndrome to the more severe Meckel-Gruber syndrome with perinatal lethality and occipital encephalocele
Our data suggest that CSPP1 is required for proper primary cilium formation or stability and that CSPP1 mutations result in abnormal mid-hindbrain development.
CSPP1 mutations are a major cause of the Joubert-Jeune phenotype in humans.
CSPP isoforms require their common C-terminal domain to interact with Nephrocystin 8 (NPHP8/RPGRIP1L (show RPGRIP1L Antibodies)) and to form a ternary complex with NPHP8 (show RPGRIP1L Antibodies) and NPHP4 (show NPHP4 Antibodies).
Novel centrosome/microtubule-associated coiled-coil protein (CSPP)is associated with centrosomes and microtubules and may play a role in the regulation of G(1)/S-phase progression and spindle assembly [CSPP].
Taken together, CSPP and CSPP-L interact with centrosomes and microtubules and can differently affect microtubule organization.[CSPP-L]
CSPP interacts with and recruits MyoGEF (show PLEKHG6 Antibodies) to the central spindle, where MyoGEF (show PLEKHG6 Antibodies) contributes to the spatiotemporal regulation of cytokinesis.
CSPP1 interacts with centrosomes and microtubules and plays a role in cell-cycle progression and spindle organization (Patzke et al., 2005
centrosome and spindle pole-associated protein 1
, centrosome and spindle pole associated protein 1
, centrosome/spindle pole-associated protein 2
, centrosome/spindle pole-associated protein 3