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Mediates resistance to sphinganine-analog mycotoxins (SAMs) by restoring the sphingolipid biosynthesis.
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Novel mutations in CERS3 co-segregated with the ichthyosis (show LBR Proteins) phenotype in six Iranian families.
testis-specific (show THEG Proteins) SLs (show ALDH3A2 Proteins), which we also link to CerS3 in human testis, are quintessential for male fertility.
Our findings demonstrate that synthesis of very long chain ceramides by CerS3 is a crucial early step for the skin barrier formation and link disorders presenting with congenital ichthyosis (show LBR Proteins) to defects in sphingolipid metabolism and lipid architecture.
these data present a novel pathway involved in ARCI development and, moreover, provide the first evidence that CERS3 plays an essential role in human sphingolipid metabolism for the maintenance of epidermal lipid homeostasis.
testis-specific (show AIF1 Proteins) SLs (show ALDH3A2 Proteins), which we also link to CerS3 in human testis, are quintessential for male fertility.
Data indicate that oxidized phospholipids (OxPLs)-induced ceramide synthases (CerS1 (show CERS1 Proteins)-Cers6 (show CERS6 Proteins)) activity in macrophages is responsible for the accumulation of ceramide.
Deficiency of CerS3 in mice results in complete loss of ceramides with ultra-long-chain acyl moities (>/=C26), lack of continuous extracellular lipid lamellae and a non-functional cornified lipid envelope.
The isolation and characterization of LASS3 and LASS3-long are reported.
Mediates resistance to sphinganine-analog mycotoxins (SAMs) by restoring the sphingolipid biosynthesis. Could salvage the transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi apparatus in ceramides-depleted cells after SAM exposure (By similarity).
LAG1 longevity assurance homolog 3
, LAG1 homolog, ceramide synthase 3
, longevity assurance homolog 3
, related to TRH3