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May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. Additionally we are shipping Ceramide Synthase 4 Antibodies (52) and many more products for this protein.
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CerS4-directed epidermal ceramide composition is essential to control hair follicle stem and progenitor cell behavior potentially through its regulation of BMP and Wnt (show WNT2 Proteins) signaling
Loss of CerS4 protein leads to an altered lipid composition of the sebum, which is more solidified and therefore might cause progressive hair loss due to physical blocking of the hair canal.
Data indicate that oxidized phospholipids (OxPLs)-induced ceramide synthases (CerS1 (show CERS1 Proteins)-Cers6 (show CERS6 Proteins)) activity in macrophages is responsible for the accumulation of ceramide.
Lag1p family members trh1 and trh4 (show LASS5 Proteins) regulate (dihydro)ceramide synthases responsible for production of sphingolipids containing different fatty acids
mRNA level of CerS4 is higher in cancerous cell lines and decreases following the induction of apoptosis.
Co-expression of CerS2 (show CERS2 Proteins) with CerS4/CerS6 (show CERS6 Proteins) reversed the inhibitory effect of long chain ceramides on cell proliferation and the induction of apoptosis. we detected no effect on cell proliferation.
The linkage and association of phospholipid transfer protein (show PLTP Proteins) activity to LASS4 were studied.
May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing different fatty acid donors (N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner (By similarity).
LAG1 longevity assurance homolog 4
, LAG1 homolog, ceramide synthase 4
, TRAM homolog 1
, longevity assurance homolog 4
, translocating chain-associating membrane protein homolog 1
, longevity assurance-like protein 4