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May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. Additionally we are shipping Ceramide Synthase 4 Antibodies (53) and many more products for this protein.
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These results suggest that the phosphorylation of ceramide synthases may be a key regulatory point in the control of the distribution and levels of sphingolipids of various acyl-chain lengths.
CerS4-directed epidermal ceramide composition is essential to control hair follicle stem and progenitor cell behavior potentially through its regulation of BMP and Wnt signaling
Loss of CerS4 protein leads to an altered lipid composition of the sebum, which is more solidified and therefore might cause progressive hair loss due to physical blocking of the hair canal.
Data indicate that oxidized phospholipids (OxPLs)-induced ceramide synthases (CerS1-Cers6) activity in macrophages is responsible for the accumulation of ceramide.
Lag1p family members trh1 and trh4 regulate (dihydro)ceramide synthases responsible for production of sphingolipids containing different fatty acids
nine SNPs in the ceramide synthase 4 (CERS4) region were associated with circulating C23:0 levels (adjusted P<5x10-2)
mRNA level of CerS4 is higher in cancerous cell lines and decreases following the induction of apoptosis.
Co-expression of CerS2 with CerS4/CerS6 reversed the inhibitory effect of long chain ceramides on cell proliferation and the induction of apoptosis. we detected no effect on cell proliferation.
The linkage and association of phospholipid transfer protein activity to LASS4 were studied.
May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing different fatty acid donors (N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner (By similarity).
LAG1 longevity assurance homolog 4
, LAG1 homolog, ceramide synthase 4
, TRAM homolog 1
, longevity assurance homolog 4
, translocating chain-associating membrane protein homolog 1
, longevity assurance-like protein 4