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The protein encoded by CCT5 is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). Additionally we are shipping CCT5 Antibodies (76) and CCT5 Kits (1) and many more products for this protein.
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CCT5 complex caps (show CAPS Proteins) mutant mHTT fibrils at their tips and encapsulates mHTT oligomers, providing a structural description of the inhibition of mHTTQ46-Ex1 (show FRMD6 Proteins) by CCT5 complex and a shared mechanism of mHTT inhibition between TRiC (show MARVELD2 Proteins) chaperonin (show HSPD1 Proteins) and the CCT5 complex
H147R CCT5 was not as efficient in chaperoning these substrates as wild type CCT5.
Both CCT4 (show CCT4 Proteins) and CCT5 homo-oligomers have the property of forming 8-fold double rings absent the other subunits, and these complexes carry out chaperonin (show HSPD1 Proteins) reactions without other partner subunits.
introduction of the truncated human CCT epsilon subunit (show CHRNE Proteins) into yeast cells
A missense mutation within the CCT5 gene is associated with autosomal recessive mutilating sensory neuropathy with spastic paraplegia.
mRNA expression of CCT5, RGS3 (show RGS3 Proteins), and YKT6 (show YKT6 Proteins) was significantly up-regulated in p53 (show TP53 Proteins)-mutated tumors and associated with a low response rate to docetaxel.
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. In addition, three pseudogenes of this gene have been identified.
T-complex protein 1 subunit epsilon
, T-complex protein 1, epsilon subunit
, chaperonin subunit 5 (epsilon)
, TCP-1 epsilon
, chaperonin containing TCP1, subunit 5 (epsilon)
, chaperonin containing TCP1, subunit 5 (epsilon) a
, T-complex protein 1 subunit epsilon-like
, t-complex protein 1 subunit epsilon-like