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CXCR3 encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant).
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Human CXCR3 ELISA Kit for Sandwich ELISA - ABIN366833
Zhang, Liu, Su, Shi, Chen: Serum fractalkine and interferon-gamma inducible protein-10 concentrations are early detection markers for acute renal allograft rejection. in Transplantation proceedings 2014
the expression of chemokine (show CCL1 ELISA Kits) receptors in different peripheral blood T-cell subsets in patients with polymyositis (PM) and dermatomyositis, was examined.
Results suggest that infiltration of chemokine (C-X-C motif) receptor 3 (CXCR3)-positive plasma cells is a characteristic feature of Hunner type interstitial cystitis (HIC).
Results of this study indicate that CXCR3 overexpression in GC is associated with increased DC and TIL (show TLR1 ELISA Kits) infiltration and improved OS.
Following activation with T-cell receptor and co-culture with various concentrations of chrysotile fibers using freshly isolated CD4 (show CD4 ELISA Kits)+ surface CXCR3 positive and negative fractions, the intracellular expression of CXCR3, IFNgamma and IL-17 (show IL17A ELISA Kits) remained unchanged when co-cultured with chrysotile.
In conclusion, it seems that decreased expression of CXCR3 and higher expression of CCR6 (show CCR6 ELISA Kits) were associated with HTLV-1 infection, what indicate that these alterations may favor virus dissemination but not disease manifestation.
Alternatively spliced variant of CXCR3 mediates the metastasis of liver cancer.
The CXCL4 (show PF4 ELISA Kits) monomer acts as the minimal active unit for interacting with CXCR3 N-Terminal Sulfated (show SULF1 ELISA Kits) Peptide, and sulfation of N-terminal tyrosine residues on the receptor is important for binding.
approach has been able to describe the structural events which dynamically characterize the molecular mechanisms involved in the binding of CXCR3 to CXCL11 (show CXCL11 ELISA Kits) and the critical role exerted by its N-terminal region in "hunting" and capturing the ligand.
High CXCR3 expression is associated with chronic lymphocytic leukaemia in comparison to small lymphocytic lymphoma.
CD4(+)CXCR3(+) T cells are h (show LY75 ELISA Kits)ighly enriched in the inflamed mucosa (show IL10 ELISA Kits) of intestinal bowel disease patients.
Study provided the evidence that CXCL10 (show CXCL10 ELISA Kits)/CXCR3 signaling in periaqueductal gray is involved in the development of morphine analgesic tolerance via neuron-microglia interaction.
The results demonstrate that the recruitment of peripheral immune cells into the CNS, induction of neuroinflammation, and consecutive weight loss during herpes encephalitis is modulated by CXCR3 signaling.
results show an important role for CXCR3 and CXCL10 (show CXCL10 ELISA Kits) in the tissue distribution of preimmune memory phenotype CD8 (show CD8A ELISA Kits) T- cells
Our data suggests that the altered gene profiles induced by CXCR3 deficiency promotes autoimmune cholangitis through pathogenic CD8 (show CD8A ELISA Kits)(+) T cells.
Data suggest that the CXCL9 (show CXCL9 ELISA Kits)-CXCR3 axis plays a pivotal role in the liver-specific distribution of TRAIL+ NK cells in mice.
ATF3 (show ATF3 ELISA Kits)-KO mice escape from PE-dependent maladaptive cardiac remodeling by suppressing the IFNgamma-CXCL10 (show CXCL10 ELISA Kits)-CXCR3 axis at multiple levels.
study thus shows that lung mucosal-resident memory T cells are not generated following systemic TB immunization and that local inflammation is required for systemically activated T cells to home to lung mucosa, which is mediated by interaction between CXCR3 upregulated in these cells and its ligands IP-10 (show CXCL10 ELISA Kits) and MIG (show CXCL9 ELISA Kits)
Antigen targeting to DEC-205 (show LY75 ELISA Kits) on dendritic cells leads to an IL-10 (show IL10 ELISA Kits)-dependent downregulation of CXCR3 expression on differentiated antigen-specific Th1 (show HAND1 ELISA Kits) cells in vivo. This downregulation interferes with the migration of Th1 (show HAND1 ELISA Kits) cells into the gut (show GUSB ELISA Kits) and protects mice against severe acute and relapsing intestinal inflammation.
this study shows that neutrophils and NK cells act as important disease-promoting immune cells in experimental osteoarthritis and their functional interaction is promoted by the CXCL10 (show CXCL10 ELISA Kits)/CXCR3 axis
These results demonstrate a critical role for both BLT1 and CXCR3 in cytotoxic T lymphocyte (CTL) migration to tumors and thus may be targeted to enhance efficacy of CTL-based immunotherapies.
Transcript analysis showed that antigen stimulation of WC1(+)gammadelta T cells substantially increased CXCR3 expression
This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716).
chemokine (C-X-C motif) receptor 3
, C-X-C chemokine receptor type 3
, G protein-coupled receptor 9
, IP-10 receptor
, IP10 receptor
, Mig receptor
, chemokine (C-X-C) receptor 3
, interferon-inducible protein 10 receptor
, CXC chemokine receptor 3
, Interferon-inducible protein 10 receptor