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Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity). Additionally we are shipping CXCL16 Antibodies (209) and CXCL16 Kits (84) and many more products for this protein.
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Data suggest that primary cells from papillary renal cell carcinoma (show MOK Proteins) secrete the chemokines IL8 (show IL8 Proteins), CXCL16, and chemerin (show RARRES2 Proteins); these chemokines attract primary human monocytes and induce shift/transdifferentiation in monocytes toward M2 macrophage/foam cell phenotype. (IL8 (show IL8 Proteins) = interleukin-8 (show IL8 Proteins); CXCL16 = C-X-C motif chemokine (show CCL1 Proteins) ligand 16)
Our study demonstrated that CXCL16-CXCR6 (show CXCR6 Proteins) mediates CD8 (show CD8A Proteins)(+) T-cell skin trafficking under oxidative stress in patients with vitiligo (show MITF Proteins), and CXCL16 expression in human keratinocytes induced by ROS (show ROS1 Proteins) is, at least in part, caused by unfolded protein response activation
eGFR (show EGFR Proteins) and serum albumin (show ALB Proteins) had an independent and significant negative correlation with plasma CXCL16 in diabetic kidney disease.
The expression of CXCL16 and and its receptor, CXCR6 (show CXCR6 Proteins), their immunolocalization in disc tissue and their presence following exposure of cultured human annulus fibrosus cells to proinflammatory cytokines are reported.
Inflammation contributed to foam cell formation in the radial arteries of ESRD patients via activation of the CXCL16/CXCR6 (show CXCR6 Proteins) pathway, which may be regulated by P2X7R (show P2RX7 Proteins).
CXCL16 single nucleotide polymorphisms significantly impacted myocardial infarction risk in a Chinese Han population.
Transmembrane-CXCL16 specifically acts as a receptor for soluble-CXCL16 in human meningioma cells.
Higher levels CXCL16 may be a biomarker for predicting stroke incidence and might contribute to plaque destabilization.
CXCL16 is released into the circulation as a result of cardiac surgery and that high post-operative CXCL16 levels are associated with an increased severity of post-operative organ dysfunctions.
Serum CXCL16 may be a novel biomarker for the diagnosis of patients with diabetic coronary artery disease.
These findings suggest that the CXCL16 gene product promotes inflammatory factors and cell infiltration factors, and inhibits the expression of antioxidant factors to accelerate the development of DN, and CXCL16 deficiency attenuates DN may be involved in the AKT (show AKT1 Proteins) signaling pathway.
Results indicate that CXCL16 plays a pivotal role in the pathogenesis of renal artery stenosis-induced renal injury and fibrosis through regulation of bone marrow-derived fibroblast accumulation and macrophage and T-cell infiltration.
Simvastatin exerts a protective effect on renal function and structure in mice with ADR (show SARS Proteins) nephropathy which related to the decreasing expression of CXCL16 in glomerular podocytes followed by the decreasing endocytosis of ox-LDL in podocytes and inhibition of NF-kappaB (show NFKB1 Proteins) pathway activation.
These results indicate that MEK (show MDK Proteins) inhibitor diminishes Nasopharyngeal carcinoma cell proliferation and NPC (show NPC1 Proteins)-induced osteoclastogenesis via modulating CCL2 (show CCL2 Proteins) and CXCL16 expressions.
Serum CXCL16 is increased in severe pancreatitis with infected pancreatic necrosis and identifies patients who benefit from surgical necrosectomy
injured hepatocytes up-regulated CXCL16 expression, indicating that scavenging functions of CXCL16 might be additionally involved in the pathogenesis of NAFLD.
role of IFN-gamma (show IFNG Proteins), CXCL16, and ADAM10 (show ADAM10 Proteins) in oxLDL-induced lipid accumulation in glomerular podocytes
CXCL16 suppresses liver metastasis of colorectal cancer by promoting TNF-alpha (show TNF Proteins)-induced apoptosis by tumor-associated macrophages.
Loss of sst2 (show SSTR2 Proteins) from pancreatic tissues activates PI3K signaling via AKT (show AKT1 Proteins), leading to activation of NF-kappaB (show NFKB1 Proteins), amplification of oncogenic KRAS signaling, increased expression of CXCL16, and pancreatic tumor formation.
CXCL16 was constitutively expressed by CX3CR1 (show CX3CR1 Proteins)(+) intestinal dendritic cells (DCs) and coexpressed with IL-23 (show IL23A Proteins) after Citrobacter rodentium infection.
Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity). Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo.
chemokine (C-X-C motif) ligand 16
, small inducible cytokine B14
, C-X-C motif chemokine 16
, CXC chemokine ligand 16
, scavenger receptor for phosphatidylserine and oxidized low density lipoprotein
, small-inducible cytokine B16
, transmembrane chemokine CXCL16
, Cxc chemokine ligand 16
, zinc finger, MYND-type containing 15
, Transmembrane chemokine CXCL16