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may be a member of the chemokine receptor family [RGD, Feb 2006].. Additionally we are shipping CMKLR1 Antibodies (165) and CMKLR1 Kits (6) and many more products for this protein.
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Chemerin (show RARRES2 Proteins)-CMKLR1 activates Akt (show AKT1 Proteins)/mTOR (show FRAP1 Proteins) and ERK (show EPHB2 Proteins) pathways and facilitates preadipocyte proliferation, adipogenesis, and angiogenesis. Gax (show MEOX2 Proteins) weakens the effect of chemerin (show RARRES2 Proteins) on preadipocyte biofunctions.
CMKLR1 exacerbated the proliferation and migration of VSMCs by activating ERK1/2.
CMKLR1 gene deletion attenuates the effects of chronic DHT treatment on ovarian function in experimental PCOS, likely via BMP4 (show BMP4 Proteins) signaling.
Loss of CMKLR1 exacerbates glucose intolerance and insulin (show INS Proteins) resistance in mice fed high fat diets.
The chemerin15 (C15) precursor, chemerin, and its receptor, ChemR23, are both upregulated after skin damage and the receptor is expressed by macrophages, neutrophils, and keratinocytes. C15 delivery dampens immediate inflammatory events.
Results indicate that Abeta42 activates CMKLR1, leading to glia cell migration and clearance of Abeta42; and is involved in Abeta (show APP Proteins) processing and clearance
Increased chemerin (show RARRES2 Proteins) expression in dermal blood vessels may be associated with the development of digital ulcers in systemic sclerosis.
In brown adipose tissue, cold acclimation strongly diminished chemerin (show RARRES2 Proteins) gene expression, whereas obesogenic diets augmented expression.
Hematopoietic Deletion of Cmklr1 Does not Affect the Development of Insulin (show INS Proteins) Resistance or nonalcoholic fatty liver disease.
ChemR23 is expressed in neutrophil granules and rapidly upregulated upon neutrophil activation.
Both ALX and ChemR23 were present in human synovium and medial tibial plateau bone obtained following total knee replacement surgery for osteoarthritis.
fact, leukotriene B4 (LTB4) is an eicosanoid lipid derivative of arachidonic acid, which primarily binds itself to the high-affinity G protein-coupled receptor BLT1. BLT1 plays an indispensable role in atherosclerosis. Hence, the BLT1 antagonist might have a therapeutic role in treating atherosclerosis. [review]
Results show that ChemR23 is highly expressed in squamous oesophageal cancer tumors and cell lines.
A novel regulatory mechanism for SNAP23-dependent mast cell activation of T. vaginalis-secreted LTB4 involving surface trafficking of BLT1.
We demonstrated that chemerin (show RARRES2 Proteins) is linked to metabolic syndrome components. Moreover, serum chemerin (show RARRES2 Proteins) levels were associated significantly with obesity, especially visceral adipose tissue, in subjects with T2DM [type 2 diabetes mellitus].
Study shows that hepatic CMKLR1 mRNA is weakly associated with features of NASH (show SAMSN1 Proteins) in male patients only.
Our results show that higher levels of circulating chemerin (show RARRES2 Proteins), CRP (show CRP Proteins), fibrinogen, and ESR (show ESR1 Proteins) are associated with an increased risk of developing colorectal cancer
Data show inverse Relationship of the CMKLR1 Relative Expression and Chemerin (show RARRES2 Proteins) Serum Levels in Obesity with Dysmetabolic Phenotype and Insulin (show INS Proteins) Resistance
RAGE has been identified as a novel binding protein for BLT1; RAGE modulates downstream signaling from BLT1 and affects cell migration through BLT1 both in vitro and in vivo.
may be a member of the chemokine receptor family
G-protein coupled receptor ChemR23
, G-protein coupled receptor DEZ
, chemerin receptor
, chemokine receptor-like 1
, orphan G-protein coupled receptor, Dez
, resolvin E1 receptor
, G-protein coupled receptor 27
, G-protein coupled chemoattractant-like receptor
, chemokine-like receptor 1
, seven transmembrane helix receptor