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Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. Additionally we are shipping Chitinase 3-Like 1 (Cartilage Glycoprotein-39) Antibodies (105) and Chitinase 3-Like 1 (Cartilage Glycoprotein-39) Kits (71) and many more products for this protein.
Showing 10 out of 24 products:
Human CHI3L1 Protein expressed in HEK-293 Cells - ABIN2713970
Cantó, Tintoré, Villar, Costa, Nurtdinov, Álvarez-Cermeño, Arrambide, Reverter, Deisenhammer, Hegen, Khademi, Olsson, Tumani, Rodríguez-Martín, Piehl, Bartos, Zimova, Kotoucova, Kuhle, Kappos et al.: Chitinase 3-like 1: prognostic biomarker in clinically isolated syndromes. ... in Brain : a journal of neurology 2015
The mouse model was used to validate the function of CHI3L1 in cancer metastasis in vivo
CHI3L1-mediated cell proliferation/survival involves partial downregulation of the pro-apoptotic S100A9 (show S100A9 Proteins) protein that is highly expressed during the acute phase of colitis, by binding to the S100A9 (show S100A9 Proteins) receptor, RAGE (show AGER Proteins) (Receptor for Advanced Glycation End products).
IL-18 (show IL18 Proteins) is a potent stimulator of Chi3l1 and that Chi3l1 is an important mediator of IL-18 (show IL18 Proteins)-induced inflammatory, fibrotic, alveolar remodeling, and cytotoxic responses.
CHI3L1 is induced during fungal infection, and it regulated antifungal innate immune responses in the cornea.
Astrocytic expression of chitinase 3-like protein 1 limits the extent of both astrocytic and microglial/macrophage facets of neuroinflammation.
Results do not support a role of BRP (show GDF5 Proteins)-39 in the pathogenesis of experimental autoimmune encephalitis.
CHI3L1 was increased in plasma and brain tissue in experimental cerebral malaria, but targeted Chi3l1 deletion did not alter cytokine production or survival in this model.
mechanism of BRP (show GDF5 Proteins)-39 in bleomycin-induced pulmonary fibrosis
Sem7a and its receptors regulate Chi3l1 in pulmonary melanoma metastasis
Data show that IL-1 (show IL1A Proteins)-induced transcriptin factor RelB (show RELB Proteins)/NF-kappa B p50 (show NFKB1 Proteins) Subunit complex formation was further promoted by oncostatin M (show OSM Proteins) and that these complexes directly bound to the secreted protein cartilage glycoprotein 39 (YKL-40) promoter.
the level of CHI3L1 protein in the sera of patients with gastric or breast cancer was significantly elevated compared with those of healthy donors. M2 macrophage-secreted CHI3L1 promoted the metastasis of gastric and breast cancer cells in vitro and in vivo
Besides being associated with tau pathology, CSF (show CSF2 Proteins) YKL-40 adds to the growing array of biomarkers reflecting distinct molecular brain mechanisms potentially useful for stratifying individuals for biomarker-guided, targeted anti-inflammatory therapies emerging from precision medicine.
SNPs in CHI3L1 and cord blood YKL-40 were not associated with lung function measurements at 5 weeks and 6 years, respiratory symptoms in the first year, and allergic sensitisation at 6 years. Genetic variation in CHI3L1 might be related to the development of milder forms of asthma.
Increased serum YKL-40 was related with poor collateral development and high SYNTAX score in patients with coronary artery disease.
Plasma YKL-40 and IL-6 (show IL6 Proteins) had less diagnostic impact than CA 19.9
Findings show high level of both YKL-40 and GAP-43 (show GAP43 Proteins) in CSF (show CSF2 Proteins) of older women with suicidal ideation which suggest that a disrupted synaptic glial functioning and inflammation may be related to the aetiology of suicidal ideation in older adults.
fibroblast-derived Chi3L1 as a novel key player in the complex reciprocal interactions of stromal cells that facilitate tumor progression and metastasis.
Findings suggest that elevated serum YKL-40 levels are associated with the existence of uterine leiomyomas, and YKL-40 might be a potential adjunct biomarker for diagnosis of uterine leiomyomas.
Collagen binds in two locations at the YKL-40 surface, potentially related to a role in fibrillar formation. Finally, heparin non-specifically binds at the YKL-40 surface, as predicted from structural studies
This is the first report on the association between low-frequency and common variants in the chitinases-related genes CHIA and CHI3L1 with the intensity of specific IgE to ABA-1 in a population naturally exposed to Ascaris and with Bet v 1 in a Swedish population.
chitinase-like lectin, YKL-40, binds specifically to type I collagen and modulates the rate of type I collagen fibril formation
Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes a glycoprotein member of the glycosyl hydrolase 18 family. The protein lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. The protein is thought to play a role in the process of inflammation and tissue remodeling.
, cartilage glycoprotein 39
, chitinase-3-like protein 1
, 39 kDa synovial protein
, 38 kDa heparin-binding glycoprotein
, signal-processing protein
, 39 kDa whey protein
, 40 kDa secretory signalling glycoprotein
, cartilage glycoprotein-39
, chitinase-like protein 1
, signal processing protein
, chitinase 3-like 1 protein
, mammary gland protein 40