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CLCN6 encodes a member of the voltage-dependent chloride channel protein family. Additionally we are shipping Chloride Channel, Voltage-Sensitive 6 Antibodies (27) and Chloride Channel, Voltage-Sensitive 6 Proteins (6) and many more products for this protein.
These findings implicate the effect of rare coding variants in CLCN6 in Blood Pressure variation and offer new insights into Blood Pressure regulation.
A non-synonymous single nucleotide variation (SNV) was identified in the voltage-sensitive chloride channel 6 gene.
late endosomal ClC-6 mediates proton/chloride countertransport in heterologous plasma membrane expression
differential sorting of endogenous (late endosomal) versus overexpressed (early and recycling endosomal) ClC-6 is reminiscent of that of other late endosomal/lysosomal membrane proteins
This study demonistrated that clcn6 gene expression in mouse dorsal raphe nucleus
Chloride channel 6 (Clcn6) deficient mice have a later-onset form of mild neurologic dysfunction similar to neuronal ceroid lipofuscinosis.
ClC-6 protein is almost exclusively expressed in neurons of the central and peripheral nervous systems, with a particularly high expression in dorsal root ganglia.
This gene encodes a member of the voltage-dependent chloride channel protein family. Members of this family can function as either chloride channels or antiporters. This protein is primarily localized to late endosomes and functions as a chloride/proton antiporter. Alternate splicing results in both coding and non-coding variants. Additional alternately spliced variants have been described but their full-length structure is unknown.
chloride transport protein 6
, chloride channel protein 6
, chloride channel 6
, chloride channel CLC-6
, chloride transport protein 6-like