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CLCN3 encodes a calcium-independent phospholipid-binding protein whose expression increases in serum-starved cells. Additionally we are shipping Chloride Channel 3 Antibodies (106) and Chloride Channel 3 Proteins (7) and many more products for this protein.
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This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
H(+)/Cl(-) exchange transporter 3
, chloride channel 3
, chloride channel protein 3
, chloride transporter ClC-3
, protein kinase C-regulated chloride channel
, chloride channel Clc-3
, Chloride channel protein 3
, H(+)/Cl(-) exchange transporter 3-like
, putative chloride channel ClC-3