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CHRNA6 encodes an alpha subunit of neuronal nicotinic acetylcholine receptors. Additionally we are shipping CHRNA6 Antibodies (31) and CHRNA6 Proteins (7) and many more products for this protein.
Using behavioral and cellular measures of alpha6 * nAChR function, study demonstrated that the ventral tegmental area is a key site of action for nicotine at alpha6 * nAChRs
these data indicate that a6)nAChR (show CHRNA4 ELISA Kits) do not have an impact on motor output.
enhanced alpha6beta2* nAChR (show CHRNA4 ELISA Kits) activity in nucleus accumbens can stimulate dopamine production
Chrna6 expression decreases with death of RGCs in glaucomatous DBA/2J mice and after optic nerve cr (show THY1 ELISA Kits)ush injury, further supporting Chrna6 as a reliable RGC marker.
While the Chrna6 gene did not significantly influence ethanol consumption (g/kg) or ataxia, mice lacking the alpha6 subunit took significantly longer to recover their righting reflex than WT animals
beta3 subunit coexpression promotes function of alpha6*-nAChR
analysis of N-terminal extracellular domain determinants in nicotinic acetylcholine receptor (nAChR (show CHRNA4 ELISA Kits)) alpha6 subunits that influence effects of wild-type or mutant beta3 subunits on function of alpha6beta2*- or alpha6beta4*-nAChR (show CHRNA4 ELISA Kits)
Data show that in Prkce (show PRKCE ELISA Kits)(-/-) mice, conditioned place preference and self-administer behaviors are associated with reduced levels of alpha(6) and beta(3) nicotinic receptor subunit mRNA in the ventral midbrain and striatum.
and chrna4 (show CHRNA4 ELISA Kits) RNAs were each expressed in a unique pattern, which changed during development
To gain a better understanding of the pathological processes underlying ND and ND-related behaviors and to promote the development of effective smoking cessation therapies, we here present the most recent studies concerning the genetic effects of the CHRNB3-CHRNA6 gene cluster in ND.
More low frequency variants in the CHRNA6/CHRNB3 gene region were observed in cases compared to controls.
Chrna6 has a cellular expression signature for retinal ganglion cells with high correlation to Thy1 (show THY1 ELISA Kits), a known marker. Immunofluorescence confirms this gene is preferentially expressed by RGCs in the young and adult mouse retina and expression is reduced in glaucoma.
the CHRNB3-A6 locus contains multiple variants affecting risk for vulnerability to cocaine and nicotine dependence as well as bipolar disorder, suggesting that they have pleiotropic effects.
Polymorphism in CHRNA6 gene is associated with esophageal adenocarcinoma.
The common variant rs13273442 in the CHRNB3 (show CHRNB3 ELISA Kits)-CHNRA6 region is associated significantly with nicotine dependence in European Americans and African Americans.
these results demonstrate that the combined effect of rs6474412-C/T polymorphism in smoking-related CHRNB3-CHRNA6 region gene and smoking behavior may not confer risk to psoriasis vulgaris (PV), but may have impact on PV severity in Chinese Han population.
findings indicate that both CHRNA2 and CHRNA6 play a significant role in the etiology of ND in AA and EA smokers
Results demonstrate the association between SNPs in CHRNA6 nicotinic acetylcholine receptor genes and the risk of smoking in ADHD
Cross sectional data of US adults from the NHANES linked with genotype and geocodes were used to identify tobacco use phenotypes, state-level taxation rates, and variation in the nicotinic acetylcholine receptor (CHRNA6) genotype
This gene encodes an alpha subunit of neuronal nicotinic acetylcholine receptors. These receptors consist of five subunits and function as ion channels involved in neurotransmission. The encoded protein is a subunit of neuronal nicotinic acetylcholine receptors that mediate dopaminergic neurotransmission and are activated by acetylcholine and exogenous nicotine. Alternatively spliced transcript variants have been observed for this gene. Single nucleotide polymorphisms in this gene have been associated with both nicotine and alcohol dependence.
cholinergic receptor, nicotinic, alpha polypeptide 6
, neuronal acetylcholine receptor subunit alpha-6
, alpha 6 nicotinic acetylcholine receptor subunit
, acetylcholine receptor alpha 6 neural
, alpha6 nAChR
, nicotinic acetylcholine receptor subunit alpha 6
, neuronal acetylcholine receptor protein, alpha-6 subunit
, neuronal nicotinic acetylcholine receptor alpha 6
, acetylcholine receptor, nicotinic, alpha 6 (neuronal)
, cholinergic receptor, nicotinic, alpha 6
, neuronal acetylcholine receptor subunit alpha-6-like