anti-Cholinergic Receptor, Nicotinic, beta 4 (Neuronal) (CHRNB4) Antibodies

may act as a subunit of a neuronal nicotinic acetylcholine receptor. Additionally we are shipping and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CHRNB4 1143 P30926
CHRNB4 25103 P12392
CHRNB4 108015 Q8R493
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Top anti-CHRNB4 Antibodies at antibodies-online.com

Showing 10 out of 58 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Goat Un-conjugated ELISA, IHC   100 μg Log in to see 6 to 7 Days
$429.84
Details
Human Goat Un-conjugated ELISA, IHC, IHC (p) Anti-CHRNB4 antibody IHC staining of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN962642 concentration 41396 ug/ml. Anti-CHRNB4 antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml. 50 μg Log in to see 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated ELISA, IHC, WB Western blot analysis of CHRNB4 using HuvEc whole cell lysates ABIN6279610 at 1/100 staining Human liver cancer tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22¡ãC. An HRP conjugated goat anti-rabbit antibody was used as the secondary 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Mouse Un-conjugated ELISA, FACS, ICC, WB Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng) Western blot analysis using CHRNB4 mAb against human CHRNB4 (AA: extra 22-236) recombinant protein. (Expected MW is 51 kDa) 100 μg Log in to see 3 to 4 Days
$430.10
Details
Human Rabbit Un-conjugated WB Western blot analysis in 293 cell line lysates (35ug/lane). 400 μL Log in to see 2 to 3 Days
$515.63
Details
Human Goat Un-conjugated IHC (p), ELISA 50 μg Log in to see 12 to 14 Days
$686.14
Details
Cow Goat Un-conjugated ELISA   0.1 mg Log in to see 7 to 9 Days
$375.73
Details
Human Rabbit Un-conjugated WB   100 μg Log in to see 11 to 14 Days
$1,013.83
Details
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (38.21 KDa) . 50 μL Log in to see 11 to 12 Days
$238.67
Details
Human Mouse Un-conjugated ELISA, WB Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng) Western blot analysis using CHRNB4 mAb against human CHRNB4 (AA: extra 22-236) recombinant protein. (Expected MW is 51 kDa) 100 μg Log in to see 3 to 4 Days
$430.10
Details

Top referenced anti-CHRNB4 Antibodies

  1. Human Polyclonal CHRNB4 Primary Antibody for WB - ABIN1881200 : Zhang, Kranzler, Poling, Gelernter: Variation in the nicotinic acetylcholine receptor gene cluster CHRNA5-CHRNA3-CHRNB4 and its interaction with recent tobacco use influence cognitive flexibility. in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2010 (PubMed)
    Show all 4 Pubmed References

  2. Cow (Bovine) Polyclonal CHRNB4 Primary Antibody for ELISA - ABIN451672 : Liang, Salas, Marubio, Bercovich, De Biasi, Beaudet, Dani: Functional polymorphisms in the human beta4 subunit of nicotinic acetylcholine receptors. in Neurogenetics 2005 (PubMed)

  3. Human Polyclonal CHRNB4 Primary Antibody for ELISA, WB - ABIN560371 : Rezvani, Teng, De Biasi: The ubiquitin-proteasome system regulates the stability of neuronal nicotinic acetylcholine receptors. in Journal of molecular neuroscience : MN 2010 (PubMed)

More Antibodies against CHRNB4 Interaction Partners

Human Cholinergic Receptor, Nicotinic, beta 4 (Neuronal) (CHRNB4) interaction partners

  1. Results indicate rs4887074 is associated with nicotinic receptor CHRNB4 expression, and along with two regulatory variants of nicotinic receptors CHRNA3 and CHRNA5, modulates the effect of rs16969968 on nicotine dependence risk.

  2. We discovered a genome-wide significant interaction of the marker rs12440014 within the gene CHRNB4. The well-established association of the genomic region 15q25 to lung cancer might be influenced by exposure to radon among uranium miners.

  3. our results show that a genomic region with functionally related genes, such as the CHRNA5/CHRNA3/CHRNB4 cluster, is under coordinated regulatory control.

  4. The results of this study suggests a pleiotropic role of Chr15q25 CHRNA5-CHRNA3-CHRNB4 gene cluster with complex influences in ADHD, tobacco smoking and cognitive performance.

  5. focus on the CHRNA5/A3/B4 gene cluster and its role in nicotine dependence (review)

  6. MAFA controls autonomic nervous system-mediated insulin secretion by activating the transcription of nicotinic (ChrnB2 and ChrnB4) receptor genes, which is impaired in patients with type 2 diabetes.

  7. Our data suggest that gene variance in the CHRNA5-CHRNA3-CHRNB4 cluster is associated with an increased risk of death, incidence of COPD and tobacco-related cancer in smokers.

  8. two SNPs (rs6495308 and rs11072768) in CHRNA5-A3-B4 have a indirect effect on lung cancer through smoking behaviors

  9. Data suggest that CHRNA5-A3-B4 gene variants do not exhibit a robust association with smoking cessation and are unlikely to be useful for clinically optimizing smoking cessation pharmacotherapy for Caucasian smokers.

  10. CHRNA5-A3-B4 genotype associates with body mass index in never smokers.

  11. Identified a novel exon variant Ser140Gly of CHRNB4 , and validated two previously reported variants Tyr215Tyr and Asp398Asn are significantly associated with COPD risk in Chinese.

  12. Study provides new evidence that the overexpression of the CHRNA5/A3/B4 region disrupts pyramidal neuronal structure in the hippocampus, and thus affecting the cognitive capacities

  13. We identified 10 low frequency non-synonymous variants in CHRNB4, and found a highly significant correlation between carrier status weighted by either ACh EC50 or by low response to nicotine.

  14. Suggest no relationship between these smoking-related SNPs in the CHRNA5/A3/B4 gene cluster and psoriasis vulgaris in Chinese Han population.

  15. Unmethylation of the CHRNB4 gene is an unfavorable prognostic factor in non-small cell lung cancer.

  16. In Mendelian randomisation analyses, there was no strong evidence that the minor allele of rs16969968/rs1051730 was associated with depression, anxiety or psychological distress in current or former smokers. [Meta-analysis]

  17. The alpha3beta4* nicotinic ACh receptor subtype mediates physical dependence to morphine

  18. Increased expression of NeuroD1 subsequently leads to regulation of expression and function of the nicotinic acetylcholine receptor subunit cluster of alpha3, alpha5, and beta4.

  19. Genetic variants in the CHRNA5-A3-B4 gene cluster alter nicotine intake and body mass index in a population of Alaska Native people, who have a distinct haplotype structure, smoking behaviors and prevalence of obesity.

  20. Elucidation of molecular impediments in the alpha6 subunit for in vitro expression of functional alpha6beta4* nicotinic acetylcholine receptors.

Mouse (Murine) Cholinergic Receptor, Nicotinic, beta 4 (Neuronal) (CHRNB4) interaction partners

  1. These findings suggest that beta4* nAChRs in the interpeduncular nucleus have a role in maintaining nicotine intravenous self-administration.

  2. Data suggest that the nicotinic acetylcholine receptor beta4 subunit (beta4 subunit) is not involved in ethanol responses.

  3. MAFA controls autonomic nervous system-mediated insulin secretion by activating the transcription of nicotinic (ChrnB2 and ChrnB4) receptor genes, which is impaired in type 2 diabetes.

  4. The alpha3beta4* nicotinic ACh receptor subtype mediates physical dependence to morphine

  5. nAChRs that contain the beta4 subunit are important for social behaviors.

  6. Downregulation of nAChR subunit and PSD-93 expression after cavernous nerve injury, or even manipulation, could interrupt synaptic transmission within the MPG and thus contribute to the loss of neural control of urogenital organs after pelvic surgeries.

  7. findings suggest an important role for the a3b4* nAChR subtype in nicotine reward and physical aspects of the nicotine withdrawal syndrome.

  8. Chrnb4 is involved in anxiety- and perhaps depression-like behaviors and contribute to the analgesic effects of nicotine.

  9. mutation depressed fusion rates of alpha4beta4 receptor-containing vesicles with the plasma membrane by approximately 2-fold, with only a small decrease in the number of nAChRs per vesicle. The mutation also decreased the number of endoplasmic reticulum exit sites

  10. At higher doses, varenicline is an agonist of Chrnb4 producing physiological changes in mice.

  11. the present results indicate an important role for Chrna7 and Chrnb4 -containing nicotinic acetylcholine receptors in the anhedonic or somatic signs of nicotine withdrawal

  12. A mechanistic model provides sharpening of mitral cell receptive fields by activation of the alpha3beta4 subtype of nicotinic receptor, which could aid in odor discrimination and perceptual learning.

  13. This study demonstrated thatalpha3beta4alpha5 receptor-mediated mechanisms contributing to nicotine consumption, and identifies the medial habenula as a critical element in the circuitry controlling nicotine-dependent phenotypes.

  14. CA box is critical for beta4 promoter activity in vivo.

  15. Polymorphisms located within the Chrna5-Chrna3-Chrnb4 cluster on mouse chromosome 9 were found to co-segregate with alcohol preference, with high-drinking F(2) mice carrying B6 alleles and low-drinking F(2) mice carrying D2 alleles.

  16. beta 4 subunits are important components of nAChRs in autonomic ganglia. Deficiency of beta 4 subunits altered ion channel properties, conductance, and sensitivity and affinity of receptors to agonists and antagonists, affecting ganglionic transmission.

  17. Tests on beta4-knockout mice revealed beta4-containing nAChRs influence behavioral responses during anxiety-related tests, and that this effect depends on the type of anxiety-provoking experience

  18. Immunohistochemical analysis of nAChRbeta4 in the mouse brain suggests an extensive and potentially diverse role for this subunit in both excitatory and inhibitory neurotransmission.

  19. There is a a major role for beta4-containing nicotinic acetylcholine receptors in the appearance of nicotine withdrawal symptoms.

  20. The involvement of the beta4 nAChR subunit in both core body temperature homeostasis and nicotine-elicited thermo-alterations in mice.

Cow (Bovine) Cholinergic Receptor, Nicotinic, beta 4 (Neuronal) (CHRNB4) interaction partners

  1. Data show that a basic residue at position 210 of the beta4 subunit slightly decreases alpha3beta4 receptor expression.

  2. Bovine chromaffin cells express nicotinic alpha3beta4 acetylcholine receptors

  3. Bovine chromaffin cells have an alpha3alpha7beta4 nicotinic receptor

CHRNB4 Antigen Profile

Protein Summary

may act as a subunit of a neuronal nicotinic acetylcholine receptor

Gene names and symbols associated with CHRNB4

  • cholinergic receptor nicotinic beta 4 subunit (CHRNB4) antibody
  • cholinergic receptor nicotinic beta 4 subunit (Chrnb4) antibody
  • cholinergic receptor, nicotinic, beta polypeptide 4 (Chrnb4) antibody
  • Acrb-4 antibody
  • Acrb4 antibody

Protein level used designations for CHRNB4

acetylcholine receptor, nicotinic, beta 4 (neuronal) , cholinergic receptor, nicotinic, beta polypeptide 4 , neuronal acetylcholine receptor subunit beta-4 , neuronal nicotinic receptor beta 4 subunit , Acetylcholine receptor beta 4 , N-alpha 2 , neuronal acetylcholine receptor non-alpha-2 chain , nicotinic acetylcholine receptor beta4 subunit , N-alpha 3 , neuronal acetylcholine receptor non-alpha-3 chain , nicotinic acetylcholine receptor beta-4 (non-alpha-3) subunit , cholinergic receptor, nicotinic, beta 4

GENE ID SPECIES
1143 Homo sapiens
25103 Rattus norvegicus
108015 Mus musculus
100231842 Taeniopygia guttata
282181 Bos taurus
395613 Gallus gallus
453570 Pan troglodytes
482110 Canis lupus familiaris
100595897 Nomascus leucogenys
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