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CHRD encodes a secreted protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta-like bone morphogenetic proteins and sequestering them in latent complexes.
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Human Polyclonal CHRD Primary Antibody for IHC (p), ELISA - ABIN4369824
Moll, Millet, Noël, Orsetti, Bardin, Katsaros, Jorgensen, Garcia, Theillet, Pujol, François: Chordin is underexpressed in ovarian tumors and reduces tumor cell motility. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006
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Data show that BMP-2 (show BMP2 Antibodies), BMP-4 (show BMP4 Antibodies), and BMP-7 (show BMP7 Antibodies), noggin (show NOG Antibodies), and chordin were colocalized in rimming osteoblasts, osteoclasts, and chondrocytes.
Data suggest CHRD (chordin) cleavage by tolloid-like metalloproteinases is insufficient to regulate BMP(bone morphogenetic protein)/BMPR signaling; CHRD fragments and TSG (twisted gastrulation protein) contribute to inhibition of BMP/BMPR signaling.
C-terminal chordin domains play an important role in Bone morphogenetic protein regulation.
chordin silencing increased osteogenic differentiation without supplemented BMP-2 (show BMP2 Antibodies).
results suggest that CHRD could participate in regulating BMP activity in normal ovarian surface epithelium physiology, and that its mis (show AMH Antibodies)-expression in ovarian surface epithelium may facilitate cancer incidence and/or progression
Bone morphogenetic protein (BMP) chordin is produced endogenously during osteogenic differentiation of human mesenchymal stem cells (MSCs); blockade of bone morphogenetic inhibitor chordin increases the rate of osteogenic differentiation of MSCs in vitro.
Noggin (show NOG Antibodies) and chordin were also expressed most intensely in areas of cartilage formation and there was no difference in their expression between the non-hypertrophic and hypertrophic chondrocytes.
there was no difference in the expression of the noggin (show NOG Antibodies) and chordin between healing and nonhealing fractures
Alternatively spliced variants have different patterns of expression to influence BMP activity in varying physiolgical situations.
Chordin upregulated in primary satellite cell cultures and in regenerating muscles
The data indicate a role for CV2 and Chd in the establishment of the vertebral morphogenetic field through the long-range relocalization of Chd/BMP complexes.
Data show that Brorin-like was predominantly expressed in the adult brain and embryonic neural tissues.
the BMP antagonists chordin and noggin (show NOG Antibodies) promote the inductive and trophic activities of rostral organizing centers in early development of the mammalian head
products of Bmp1 (show BMP1 Antibodies) and Tll1 (show TLL1 Antibodies) are responsible for in vivo cleavage of Chordin in mammals
chordin antagonism of bone morphogenetic protein signaling and cellular uptake of chordin require cell-surface heparan sulfate proteoglycans
results suggest that twisted gastrulation and chordin are involved in osteoblast differentiation and mineralization by regulating BMP signaling
These results demonstrate that the chordin contributes to synaptic plasticity and learning likely through a presynaptic mechanism.
chordin has a role in venous and arterial patterning and the Bone Morphogenetic Protein pathway is necessary for the process
chordin is a modifier for the craniofacial anomalies of Tbx1 (show TBX1 Antibodies) mutations.
The authors found that BMP2b and Chordin diffuse and rapidly form extracellular protein gradients, Chordin does not modulate the diffusivity or distribution of BMP2b, and Chordin is not required to establish peak levels of BMP signaling.
activation of the FGF signaling pathway induces the formation of a dorsal axis with a complete head structure through the expression of chd and subsequent maintenance of dkk1b (show DKK1 Antibodies) expression levels.
Binding of CV2 (show BMPER Antibodies) to Chordin promotes BMP-2 (show BMP4 Antibodies) signaling.
Targeted knockdown of Sox17 (show SOX17 Antibodies) and Chd in dorsal forerunner cells led to aberrant Left-Right (L-R) asymmetry establishment, as visualized by the expression of southpaw and lefty (show LEFTY2 Antibodies), and heart and pancreas placement in the embryo.
Chl (show CHRDL2 Antibodies), like Chd, dorsalizes embryos upon overexpression and is cleaved by BMP1 (show BMP1 Antibodies); loss-of-function experiments show Chl (show CHRDL2 Antibodies) serves as a BMP antagonist with functions that overlap and are redundant with those of Chd in forming the dorsoventral axis.
Data show that The inhibition of Brorin-like functions in zebrafish resulted in the impairment of neural development.
by regulating the expression of her5, the Bmp2b (show BMP4 Antibodies)/Chordin gradient directs the anteroposterior patterning of endoderm in zebrafish embryos
chd, a bone morphogenetic protein antagonist expressed in gastrulation, is dispensable for neural crest induction.
Twisted (show POMT2 Antibodies) gastrulation enhances BMP signaling through chordin dependent and independent mechanisms
specification of anterior neural tissue requires later activities of Chordin and mesodermal factors.
Chordin protein formed a smooth gradient that encircled the embryo, reaching the ventral-most Brachet cleft.
This study demonstrates a crucial role of Sizzled in coupling dorsal-ventral axis size information with Chordin stability.
Chordin, Noggin (show NOG Antibodies), beta-Catenin (show CTNNB1 Antibodies), and Cerberus (show CER1 Antibodies) have roles in neural induction in Xenopus
Bone morphogenetic protein 4 (show BMP4 Antibodies) knockdown was sufficient to rescue the ventralizing effects caused by loss of Chordin activity.
complex containing Smicl and the newly induced Xlim1 (show LHX1 Antibodies) induces expression of Chordin
Several lines of evidence support the hypothesis that chordin influences pronephros development by directing the formation of anterior somites.
Embryo elongation can occur through the synergistic effect(s) of the organizer molecule chordin, and each of the 'verall posteriorizing molecules'eFGF, VegT and Xbra.
Xld (show TLL2 Antibodies) cleaves Chordin, an inhibitory binding protein for BMP2/4 (show BMP4 Antibodies), releasing fragments with reduced affinity for these important ventralizing signals.
CV2/Chordin interaction may help coordinate bone morphogenetic protein (BMP) diffusion to the ventral side of the embryo, ensuring that BMPs liberated from Chordin inhibition by tolloid proteolysis cause peak signaling levels.
Study shows that Xenopus ONT1 (show OLFML3 Antibodies), an Olfactomedin-class secreted protein, stabilizes axial formation by restricting Chordin activity on the dorsal side. [ONT1 (show OLFML3 Antibodies)]
This gene encodes a secreted protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta-like bone morphogenetic proteins and sequestering them in latent complexes. The encoded protein may also have roles in organogenesis and during adulthood. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their full length sequence has not been determined.
, chordin protein
, dino (din)
, protein chordino
, organizer-specific secreted-dorsalizing factor