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Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development.
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Cbx8 associates with non-PRC1 (show PRC1 Proteins) complexes containing the H3K4 methyltransferase complex component WDR5 (show WDR5 Proteins), which together regulate Notch (show NOTCH1 Proteins) gene expression.
CBX8 plates roles in epigenetic regulation in DNA damage response.
Cbx8 is upregulated and recruited to activated genes during embryonic stem cell differentiation.
CBX8 plays an essential role in MLL (show MLL Proteins)-AF9 (show MLLT3 Proteins) transcriptional regulation and leukemogenesis.
Pcl2 (show MTF2 Proteins)-PRC2 facilitates both PRC2 recruitment to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells.
Huntingtin (show HTT Proteins) is a novel stimulator of polycomb (show CBX2 Proteins) repressive complex 2.
CBX8 binds with the Snai1 (show SNAI1 Proteins) promoter, represses Snai1 (show SNAI1 Proteins) transcription and suppresses esophageal carcinoma metastasis.
The data suggest that high expression of CBX8 plays a critical oncogenic role in aggressiveness of urothelial carcinoma cells of the bladder through promoting cancer cell proliferation by repressing the p53 (show TP53 Proteins) pathway, and CBX8 could be used as a novel predictor for muscle invasive bladder cancer patients.
CBX8 binds to H3K27me3 at bivalent promoters during germinal center formation, and recruits a novel PRC1 (show PRC1 Proteins)-BCOR (show BCOR Proteins) complex at BCL6 (show BCL6 Proteins) binding sites to specifically silence genes in the germinal center and promote lymphomagenesis
IGF1 (show IGF1 Proteins) can promote the colon cancer cell line, HCT116 cell, proliferation via promoting Cbx8 expression
The difference in the SUZ12 and CBX8 genes expression were significantly divergent between tumors and their marginal tissues.
These data suggest that CBX8 modulates SIPS through the RB-E2F1 pathway in CML cells and provide important insight into its application in CML treatment.
Low CBX8 expression was associated with distant metastasis in colorectal cancer.
CBX8 might emerge as an oncogene (show RAB1A Proteins) for promoting the proliferation of tumor cells and raising the resistance of neoplasms to chemotherapy.
The presence of CBX8-GFP in the same focus had a minor impact on BMI1 and RING1 recovery kinetics.
Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones\; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
chromobox homolog 8
, chromobox protein homolog 8
, polycomb 3 homolog
, Pc class 3 homolog
, chromobox homolog 8 (Pc class homolog, Drosophila)
, polycomb 3
, rectachrome 1
, chromobox-like protein 8
, chromobox homolog 8 (Pc class homolog)
, chromobox homolog 8a