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The product of CHD4 belongs to the SNF2/RAD54 helicase family.
Showing 5 out of 6 products:
RNA interference identifies CHD4 as an essential gene in regulating breast cancer growth.
Data suggest TCF19 (show TCF19 Proteins) interacts with histone 3 lysine 4 trimethylation through its plant homeodomain finger; TCF19 (show TCF19 Proteins) expression appears to regulate gluconeogenesis in hepatocytes; TCF19 (show TCF19 Proteins) interacts with CHD4 causing NuRD complex recruitment to gene promoters of enzymes involved in gluconeogenesis. (TCF19 (show TCF19 Proteins) = transcription factor 19 (show TCF19 Proteins); CHD4 = chromodomain helicase DNA binding protein 4; NuRD = nucleosome-remodeling-deacetylase)
CHD3 (show CHD3 Proteins) and CHD4 exhibit distinct nuclear localization patterns in unperturbed cells, revealing a subset of specific target genes.
The findings identify that CHD4 deficiency preferentially impairs cell survival via increasing the level of p21 (show CDKN1A Proteins).
Mutation in CHD4 gene is associated with congenital heart defects.
this work identifies CHD4 as an epigenetic coregulator of PAX3 (show PAX3 Proteins)-FOXO1 (show FOXO1 Proteins) activity, providing rational evidence for CHD4 as a potential therapeutic target in alveolar rhabdomyosarcoma.
CHD4 recruits repressive chromatin proteins to sites of DNA damage repair, including DNA methyltransferases where it imposes de novo DNA methylation (show HELLS Proteins). At TSGs, CHD4 retention helps maintain DNA hypermethylation-associated transcriptional silencing.
this study identifies the Chd4-Tbx3 (show TBX3 Proteins) axis in controlling ESC fate and a role of H2A.Z (show H2AFZ Proteins) in maintaining the stability of Chd4 proteins.
report provides evidence for the role of CHD4 in human development and expands an increasingly recognized group of Mendelian disorders involving chromatin remodeling and modification
complex lacking CHD4 that has HDAC (show HDAC3 Proteins) activity can exist as a stable species. The addition of recombinant CHD4 to this nucleosome deacetylase complex reconstitutes a NuRD complex with nucleosome remodeling activity.
Chd4 mutant embryos died before birth and exhibited severe edema, blood-filled lymphatics, and liver hemorrhage. CHD4-deficient embryos developed normal lymphovenous (LV) valves, which regulate the return of lymph to the blood circulation; however, these valves lacked the fibrin-rich thrombi that prevent blood from entering the lymphatic system.
This secreted effector, toxoplasma inhibitor of STAT1 (show STAT1 Proteins)-dependent transcription (TgIST), translocates to the host cell nucleus, where it recruits mouse Mi-2/NuRD to STAT1 (show STAT1 Proteins)-dependent promoters, resulting in altered chromatin and blocked transcription.
this study shows that the chromatin remodeler Mi-2beta controls epidermal homeostasis by regulating the genes involved in keratinocyte and immune-cell activation to maintain an inactive state
preservation of the identity of the two striated (show NSDHL Proteins) muscle types depends on epigenetic repression of the alternate lineage gene program by the chromatin remodeling complex Chd4/NuRD.
CHD4 depletion modulates expression of acute myeloid leukemia (show BCL11A Proteins) cell genes that regulate tumor formation in vivo and colony formation in vitro.
CHD4 allows cells to undertake lineage commitment in vivo by modulating the frequency with which lineage-specification genes are expressed.
Chromatin immunoprecipitation assays showed that CHD4-containing NuRD complexes directly bound the promoters of these genes in endothelial cells
Chd4, interacting with Hdac1 (show HDAC1 Proteins)/2, cooperates with its related proteins Kap1 (show TRIM28 Proteins) and Cbx1 (show CBX1 Proteins) to bind at -207/-148 of the Sox9 (show SOX9 Proteins) promoter.
CHD4 functions as a MAP required for MT stabilization and is involved in generating spindle bipolarity.
The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein.
chromodomain helicase DNA binding protein 4
, chromodomain-helicase-DNA-binding protein 4
, ATP-dependent helicase CHD4
, Mi-2 autoantigen 218 kDa protein
, Mi-2 autoantigen
, Mi-2 beta