Chromogranin B (Secretogranin 1) Proteins (CHGB)

CHGB encodes a tyrosine-sulfated secretory protein abundant in peptidergic endocrine cells and neurons. Additionally we are shipping CHGB Antibodies (66) and CHGB Kits (35) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CHGB 1114 P05060
CHGB 12653 P16014
CHGB 24259 O35314
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Top CHGB Proteins at antibodies-online.com

Showing 10 out of 19 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,626.73
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,626.73
Details
Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 15 to 18 Days
$666.00
Details
Escherichia coli (E. coli) Rat His tag,GST tag 100 μg Log in to see 15 to 18 Days
$816.00
Details
Escherichia coli (E. coli) Cow His tag,GST tag 100 μg Log in to see 15 to 18 Days
$848.00
Details
Escherichia coli (E. coli) Wild boar His tag,GST tag 100 μg Log in to see 15 to 18 Days
$864.00
Details
Escherichia coli (E. coli) Mouse Un-conjugated SDS-PAGE analysis of Mouse CHGB Protein. 100 μg Log in to see 11 to 18 Days
$696.46
Details
Escherichia coli (E. coli) Pig Un-conjugated SDS-PAGE analysis of Pig Chromogranin B Protein. 100 μg Log in to see 11 to 18 Days
$838.60
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$325.44
Details
Escherichia coli (E. coli) Human His tag 50 μg Log in to see 15 to 19 Days
$492.31
Details

CHGB Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,

Rat (Rattus) ,
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More Proteins for Chromogranin B (Secretogranin 1) (CHGB) Interaction Partners

Human Chromogranin B (Secretogranin 1) (CHGB) interaction partners

  1. evidence suggests that the P413L variant of chromogranin B is not associated with amyotrophic lateral sclerosis (ALS) risk or age at ALS onset (meta-analysis).

  2. Data suggest that chromogranin B (CGB) is a promising emerging biomarker in heart failure (HF) patients with unique potential to integrate information from myocardial stress and neuro-endocrine activation.

  3. Circulating chromogranin B (CgB) levels measured on Intensive Care Unit (ICU) admission provided additional prognostic information to established risk indices in acute respiratory failure (ARF) patients.

  4. results presented here suggest that CHGB variant alleles, the rare CHGB-L413 and common CHGB-P413, may act as modifiers of ALS disease dependent on their expression levels which is higher in females because of a sex-determining region Y element in the CHGB gene promoter.

  5. Compared with chromogranin A, chromogranin B may be more useful during proton pump inhibitor treatment and can detect tumors without liver metastases.

  6. our results suggest that genetic variants of CHGB may have sex-specific effects on the risk of schizophrenia and provide useful preliminary information for further study.

  7. Data indicate that measurement of chromogranin A (CgA) alone is sufficient in the management of patients with neuroendocrine tumours (NETs) and that routine additional measurement of chromogranin B (CgB) provides little added value.

  8. intracellular calcium binding protein Sg1 is increased in early multiple sclerosis (MS) patients compared to relapsing-remitting MS and neurological controls.

  9. The polymorphism P413L in the CHGB gene was not associated with sporadic amyotrophic lateral sclerosis in a group of Italian patients.

  10. CgA and CgB have been used as general NEN biomarkers for many years, while CART has only recently been identified

  11. A heterogeneous response to short- and long-term physical activities among circulating granin proteins, particularly chromogranin B.

  12. CgA, CgB, and secretoneurin are detectable in feces, and collagenous colitis patients express higher values than patients with inflammatory bowel disease and controls. In treatment, fecal secretoneurin decreased to control levels in collagenous colitis.

  13. Our findings suggest that altered PTEN, ATRX, CHGA, and CHGB expression are associated with aggressive PNET phenotype in VHL and may serve as useful adjunct prognostic markers to Ki-67 in PNETs.

  14. Results do not support the 413L variant of chromogranin B as a risk factor for sporadic amyotrophic lateral sclerosis in the French population.

  15. This short review deals with investigations in neuroendocrine tumors (NETs) with antibodies against defined epitopes of chromogranins (Cgs) A and B and secretogranins (Sgs) II and III.

  16. The roles of Cgs A and B in maintaining the intravesicular environment of secretory vesicles and in exocytosis, bringing together the most recent findings from adrenal chromaffin cells, are discussed.

  17. common polymorphism in the 3'-UTR (C+84A) of CHGB, which disrupts an A/U-rich messenger ribonucleic acid stability element, associates with not only CHGB secretion but also excretion of isoprostane

  18. The common CHGB promoter variants A-296C and A-261T, and their consequent haplotypes, alter binding of specific transcription factors to influence gene expression in cella as well as BP in vivo

  19. Genetic variation at the CHGB locus, in the proximal promoter, influences CHGB expression as well as catecholamine secretion and later the early heritable responses to environmental stress, and resting/basal Blood Pressure in the population.

  20. finding that CHGB may act as a susceptibility gene and modifier of onset in ALS is consistent with the emerging view that dysfunction of the secretory pathway may contribute to increased vulnerability of motor neurons

Mouse (Murine) Chromogranin B (Secretogranin 1) (CHGB) interaction partners

  1. This analysis of mice lacking Cgs highlights the important roles of CgA and CgB in glucose and cardiovascular homeostasis. This study also unveils the existence of direct implications of Cgs in the control of behaviour and mood.

  2. Chromogranin B contributes to a highly efficient system that directly mediates monoamine accumulation and exocytosis in large dense core secretory vesicles.

  3. Although chromogranins regulate the amine concentration in LDCVs, they are not completely essential.

  4. C-terminal domain of chromogranin B regulates intracellular calcium signaling.

  5. CgB is not required for normal insulin granule biogenesis or maintenance in vivo, but is essential for adequate secretion of islet hormones

  6. Chromogranin B gene ablation reduces the catecholamine cargo and decelerates exocytosis in chromaffin secretory vesicles in mice.

  7. CGB was localized in the nucleus; transcription control role of CGB in the nucleus

  8. These data suggest that RAGE signaling is capable of driving neuronal differentiation involving CREB activation and induction of chromogranin expression.

  9. Chromogranin B has a role in secretory granule biogenesis

  10. CGB may play an important modulatory role in the control of Ca2+ release from the endoplasmic reticulum

  11. Neuroendocrine-specific expression of Chgb is mediated by the CRE and G/C boxes in cis and the transcription factors CREB, AP-2, Egr-1 and Sp1.

  12. Striatal neuropeptide mechanisms in experimental parkinsonism were elucidated.

Pig (Porcine) Chromogranin B (Secretogranin 1) (CHGB) interaction partners

  1. expression and localization of chromogranin A (CgA), chromogranin B (CgB), synaptophysin, and insulin were ultrastructurally studied with the immunogold technique in porcine and human pancreatic islet neuroendocrine cells

Cow (Bovine) Chromogranin B (Secretogranin 1) (CHGB) interaction partners

  1. chromogranin B has a role in the IP(3)-mediated Ca(2+) release mechanism of secretory granules

  2. CGB may play an important modulatory role in the control of Ca2+ release from the endoplasmic reticulum

  3. colocalization of all three inositol 1,4,5-trisphosphate receptor (IP(3)R)isoforms with chromogranin B to the extent that the majority of each IP(3)R isoform-labeling gold particles found in the nucleoplasm

  4. determination of the subcellular distribution of chromogranins A and B in chromaffin cells; results suggest that chromogranins are at the center of intracellular Ca(2+) homeostasis in secretory cells

  5. Chromogranin B was found to co-localize with secretogranin II and IP3 receptors in the nucleus, more specifically, in the IP3-sensitive nucleoplasmic Ca2+ store vesicles.

CHGB Protein Profile

Protein Summary

This gene encodes a tyrosine-sulfated secretory protein abundant in peptidergic endocrine cells and neurons. This protein may serve as a precursor for regulatory peptides.

Gene names and symbols associated with CHGB

  • chromogranin B (CHGB)
  • chromogranin B (Chgb)
  • chromogranin B (chgb)
  • CGB protein
  • CHGB protein
  • Scg-1 protein
  • SCG1 protein
  • si:ch73-355e4.2 protein
  • si:cu075930.2 protein

Protein level used designations for CHGB

cgB , chromogranin-B , secretogranin B , secretogranin I , secretogranin-1 , sgI , Chromogranin B, parathyroid secretory protein , glucagonoma peptide , secretogranin-I , chromogranin B , chromogranin B (secretogranin 1)

GENE ID SPECIES
1114 Homo sapiens
12653 Mus musculus
24259 Rattus norvegicus
397154 Sus scrofa
719171 Macaca mulatta
792853 Danio rerio
281071 Bos taurus
421312 Gallus gallus
100735858 Cavia porcellus
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