Chromosome 12 Open Reading Frame 52 Proteins (C12orf52)

Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Additionally we are shipping Chromosome 12 Open Reading Frame 52 Antibodies (28) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
C12orf52 84934 Q96K30
Mouse C12orf52 C12orf52 100764 Q9D1H0
C12orf52 288683 Q2KJ10
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Top Chromosome 12 Open Reading Frame 52 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 11 Days
$814.00
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 60 to 71 Days
$2,607.00
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Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$2,665.67
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Yeast REACT_Panda His tag   1 mg Log in to see 60 to 71 Days
$2,700.50
Details
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$2,700.50
Details

C12orf52 Proteins by Origin and Source

Origin Expressed in Conjugate
Human

Rat (Rattus)

More Proteins for Chromosome 12 Open Reading Frame 52 (C12orf52) Interaction Partners

Xenopus laevis Chromosome 12 Open Reading Frame 52 (C12orf52) interaction partners

  1. The study reports the identification and functional characterization of rbpj interacting and tubulin associated (RITA) (C12ORF52) as a novel rbpj/CBF-1-interacting protein.

Human Chromosome 12 Open Reading Frame 52 (C12orf52) interaction partners

  1. structural and biophysical studies demonstrate that RITA binds RBP-J similarly to the RAM (RBP-J-associated molecule) domain of Notch, our biochemical and cellular assays suggest that RITA interacts with additional regions in RBP-J.

  2. RITA overexpression increased expression of p53 and Fbxw7 and downregulated expression of cyclin D1, cyclin E, CDK2, Hes-1 and NF-kappaB p65. These changes led to growth inhibition and induced G0/G1 cell cycle arrest and apoptosis in SMMC7721 and HepG2 cells.

  3. human RITA, binding to Drosophila Su(H) and tubulin, cannot influence the Notch signalling pathway in the fly

  4. RITA might suppress tumor growth and induce apoptosis in hepatocellular carcinoma.

Mouse (Murine) Chromosome 12 Open Reading Frame 52 (C12orf52) interaction partners

  1. structural and biophysical studies demonstrate that RITA binds RBP-J similarly to the RAM (RBP-J-associated molecule) domain of Notch, our biochemical and cellular assays suggest that RITA interacts with additional regions in RBP-J.

Chromosome 12 Open Reading Frame 52 (C12orf52) Protein Profile

Protein Summary

Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis (By similarity).

Gene names and symbols associated with C12orf52

  • RBPJ interacting and tubulin associated 1 (RITA1)
  • RBPJ interacting and tubulin associated 1 L homeolog (rita1.L)
  • RBPJ interacting and tubulin associated 1 (Rita1)
  • AI853657 protein
  • C12orf52 protein
  • C86297 protein
  • Rita protein

Protein level used designations for C12orf52

chromosome 12 open reading frame 52 , RBP-J interacting and tubulin associated , RBPJ-interacting and tubulin-associated protein

GENE ID SPECIES
712837 Macaca mulatta
100381047 Xenopus laevis
84934 Homo sapiens
533158 Bos taurus
100764 Mus musculus
288683 Rattus norvegicus
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