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Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Additionally we are shipping Chromosome 12 Open Reading Frame 52 Antibodies (28) and many more products for this protein.
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The study reports the identification and functional characterization of rbpj interacting and tubulin associated (RITA) (C12ORF52) as a novel rbpj/CBF-1-interacting protein.
structural and biophysical studies demonstrate that RITA binds RBP-J similarly to the RAM (RBP-J-associated molecule) domain of Notch, our biochemical and cellular assays suggest that RITA interacts with additional regions in RBP-J.
RITA overexpression increased expression of p53 and Fbxw7 and downregulated expression of cyclin D1, cyclin E, CDK2, Hes-1 and NF-kappaB p65. These changes led to growth inhibition and induced G0/G1 cell cycle arrest and apoptosis in SMMC7721 and HepG2 cells.
human RITA, binding to Drosophila Su(H) and tubulin, cannot influence the Notch signalling pathway in the fly
RITA might suppress tumor growth and induce apoptosis in hepatocellular carcinoma.
Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis (By similarity).
chromosome 12 open reading frame 52
, RBP-J interacting and tubulin associated
, RBPJ-interacting and tubulin-associated protein