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Histone demethylase that specifically demethylates 'Lys- 4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code.
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PHF19 (show PHF19 Proteins) associates with the H3K36me3 demethylase (show MBD2 Proteins) NO66, and it is required to recruit the PRC2 complex and NO66 to stem cell genes during differentiation
our findings clearly indicated that epigenetic regulation by NO66 plays an important role in cancer metastatic processes in CRC (show CALR Proteins).
Results show that high expression levels of SMYD2 (show SMYD2 Proteins), SETD3 (show SETD3 Proteins), and NO66 in renal cell tumors. Their low expression levels were significantly associated with shorter disease-specific and disease-free survival.
confirmed the hydroxylase activity of NO66 and showed that oligomerization is required for NO66 to efficiently catalyze the hydroxylation of Rpl8 (show RPL8 Proteins)
hinge domain-dependent oligomerization of NO66 is essential for inhibition of Osx (show MID1 Proteins)-dependent gene activation.
NO66 crystallized in space group P3(1) or P3(2), with unit-cell parameters a = 89.35, b = 89.35, c = 304.86 A, alpha = beta = 90, gamma = 120 degrees , and the crystal is likely to contain four molecules in the asymmetric unit
interactions between NO66 and Osx (show MID1 Proteins) regulate Osx (show MID1 Proteins)-target genes in osteoblasts by modulating histone methylation states
NO66 has functions in ribosome biogenesis and in the replication or remodeling of certain heterochromatic regions
NO66 regulates bone formation, at least in part, via regulating the number of bone-forming cells and expression of multiple genes that are critical for these processes
Data indicate that mesenchymal overexpression of nucleolar protein 66 (NO66) inhibits skeletal cell proliferation.
propose that Osx (show SP7 Proteins) is a molecular switch for the formation of an active chromatin state during osteoblast differentiation, whereas NO66 helps gene repression through histone demethylation and/or formation of a repressor complex
Histone demethylase that specifically demethylates 'Lys- 4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Acts as a regulator of osteoblast differentiation via its interaction with sp7/osx by demethylating H3K4me and H3K36me, thereby inhibiting sp7/osx-mediated promoter activation. May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region (By similarity).
chromosome 14 open reading frame 169
, bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66
, histone lysine demethylase NO66
, lysine-specific demethylase NO66
, myc-associated protein with JmjC domain
, nucleolar protein 66
, 60S ribosomal protein L8 histidine hydroxylase
, MYC-associated protein with JmjC domain
, ribosomal oxygenase NO66
, myc associated protein with JmjC domain
, chromosome 14 open reading frame 169-like