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C8orf4 encodes a member of the vitamin B12-binding protein family.
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Decreased capacity of fibrotic lung fibroblasts to up-regulate COX-2 expression and COX-2-derived PGE2 synthesis is due to an indirect epigenetic mechanism involving hypermethylation of the transcriptional regulator, c8orf4.
C8orf4 negatively regulates the self-renewal of liver CSCs via suppression of NOTCH2 (show NOTCH2 Proteins) signalling
the high expression of TC1 was common in oral tongue squamous cell carcinomas and correlated with the expression of b-catenin and cyclin D1 (show CCND1 Proteins) and the progression of oral tongue squamous cell carcinomas
TC-1 overexpression promotes cell proliferation in human non-small cell lung cancer that can be inhibited by PD173074.
TC-1 expression is associated with aggressive biologic behavior in lung cancer and might coordinate with the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway as a positive upstream regulator that induces these behaviors.
The higher expression of TC-1 in ovarian compared to colorectal adenocarcinomas suggests its potential use as a marker
The SNP rs10958605 in the C8orf4 gene had the smallest p value in analyses of the motor outcome.
A significant association was found between the copy-number deletions of C8orf4 and the risk of hematological malignancies.
Overexpression of TC-1 may be important in thyroid carcinogenesis.
data indicate that TC1 is a novel upstream regulator of the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway that enhances aggressive behavior of cancers
This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt\\/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. The encoded protein may also play a role in the NF-kappaB and ERK1\\/2 signaling pathways. Expression of this gene may play a role in the proliferation of several types of cancer including thyroid cancer, breast cancer and hematological malignancies.
human thyroid cancer 1
, thyroid cancer protein 1
, uncharacterized protein C8orf4
, chromosome 8 open reading frame 4