Claspin (CLSPN) ELISA Kits

The product of CLSPN is an essential upstream regulator of checkpoint kinase 1 and triggers a checkpoint arrest of the cell cycle in response to replicative stress or DNA damage. Additionally we are shipping Claspin Antibodies (18) and and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Rat CLSPN CLSPN 298534  
CLSPN 63967 Q9HAW4
CLSPN 269582 Q80YR7
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More ELISA Kits for Claspin Interaction Partners

Human Claspin (CLSPN) interaction partners

  1. Results unveil a new aspect of PERK (show EIF2AK3 ELISA Kits) function and previously unknown roles for Claspin and Chk1 (show CHEK1 ELISA Kits) as negative regulators of DNA replication in the absence of genotoxic stress.

  2. found that USP9X (show USP9X ELISA Kits) regulated the expression and stability of CLASPIN in an S-phase-specific manner. USP9X (show USP9X ELISA Kits) depletion profoundly impairs the progression of DNA replication forks, causing unscheduled termination events with a frequency similar to CLASPIN depletion, resulting in excessive endogenous DNA damage

  3. Functional analyses indicat that the expression TopBP1 (show TOPBP1 ELISA Kits) and Claspin positively affects the survival of brain cancer cells after exposure to radiation.

  4. And-1 coordinates with Claspin for efficient Chk1 (show CHEK1 ELISA Kits) activation in response to replication stress.

  5. USP29 interacts with Claspin and is able to deubiquitinate it both in vivo and in vitro.

  6. Rad9, Rad17, TopBP1 and claspin play essential roles in heat-induced activation of ATR kinase and heat tolerance.

  7. findings identify claspin as an in vivo substrate for the BRCA1 E3 ligase and suggest that its modification selectively triggers CHK1 (show CHEK1 ELISA Kits) activation for the homology-directed repair of a subset of genotoxic lesions

  8. analysis of claspin expression could be clinically relevant in the diagnosis of HPV-related cervical lesions, in particular when applied to cervico-vaginal cytology

  9. The conserved C terminus of Claspin interacts with Rad9 (show RAD9A ELISA Kits) and ensures timely activation of the ATR (show ANTXR1 ELISA Kits)-Chk1 (show CHEK1 ELISA Kits) pathway.

  10. the functions of Claspin and the functional relationship between Claspin and Rad17 (show RAD17 ELISA Kits) were studied.

Mouse (Murine) Claspin (CLSPN) interaction partners

  1. Tethering DNA damage checkpoint mediator proteins topoisomerase IIbeta-binding protein 1 (TopBP1 (show TOPBP1 ELISA Kits)) and Claspin to DNA activates ataxia-telangiectasia mutated and RAD3-related (ATR (show ATR ELISA Kits)) phosphorylation of checkpoint kinase 1 (Chk1 (show CHEK1 ELISA Kits)).

  2. Rad9A (show RAD9A ELISA Kits)-mediated Claspin localization is a vital step during checkpoint activation.

Xenopus laevis Claspin (CLSPN) interaction partners

  1. Claspin localizes to mitotic centromeres depending on mitotic SUMOylation.

  2. Claspin is phosphorylated at the midblastula transition at both DNA replication checkpoint-dependent and -independent sites.

  3. recent findings and mechanisms of checkpoint regulation by claspin

  4. the interaction of DDK with Claspin mediates a checkpoint-independent function of Claspin related to DNA replication.

  5. Claspin has roles in the Chk1 (show CHEK1 ELISA Kits) pathway and functions in checkpoint control [review]

  6. our findings suggest that only transient interaction of Claspin with replication forks potentiates its Chk1 (show CHEK1 ELISA Kits)-activating function. Also, stable binding of Claspin to chromatin may play a role in other functions besides the activation of Chk1 (show CHEK1 ELISA Kits).

Claspin (CLSPN) Antigen Profile

Antigen Summary

The product of this gene is an essential upstream regulator of checkpoint kinase 1 and triggers a checkpoint arrest of the cell cycle in response to replicative stress or DNA damage. The protein is also required for efficient DNA replication during a normal S phase. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Claspin (CLSPN) ELISA Kits

  • claspin (Clspn) antibody
  • claspin (CLSPN) antibody
  • claspin (clspn) antibody
  • claspin S homeolog (clspn.S) antibody
  • B130025E01 antibody
  • C85083 antibody
  • CLSPN antibody
  • E130314M08Rik antibody
  • xClaspin antibody

Protein level used designations for Claspin (CLSPN) ELISA Kits

claspin homolog (Xenopus laevis) , claspin , claspin homolog , hClaspin , xClaspin

298534 Rattus norvegicus
100055244 Equus caballus
456746 Pan troglodytes
100124314 Xenopus (Silurana) tropicalis
100347850 Oryctolagus cuniculus
100482920 Ailuropoda melanoleuca
100525928 Sus scrofa
100543387 Meleagris gallopavo
100567034 Anolis carolinensis
100597024 Nomascus leucogenys
63967 Homo sapiens
269582 Mus musculus
398192 Xenopus laevis
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