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The product of CLSPN is an essential upstream regulator of checkpoint kinase 1 and triggers a checkpoint arrest of the cell cycle in response to replicative stress or DNA damage.
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The functions of claspin are discussed and how its deregulation may contribute to cancer initiation and progression. [REVIEW]
Results unveil a new aspect of PERK (show EIF2AK3 ELISA Kits) function and previously unknown roles for Claspin and Chk1 (show CHEK1 ELISA Kits) as negative regulators of DNA replication in the absence of genotoxic stress.
found that USP9X regulated the expression and stability of CLASPIN in an S-phase-specific manner. USP9X depletion profoundly impairs the progression of DNA replication forks, causing unscheduled termination events with a frequency similar to CLASPIN depletion, resulting in excessive endogenous DNA damage
Functional analyses indicat that the expression TopBP1 and Claspin positively affects the survival of brain cancer cells after exposure to radiation.
And-1 coordinates with Claspin for efficient Chk1 (show CHEK1 ELISA Kits) activation in response to replication stress.
USP29 interacts with Claspin and is able to deubiquitinate it both in vivo and in vitro.
Rad9, Rad17, TopBP1 and claspin play essential roles in heat-induced activation of ATR kinase and heat tolerance.
findings identify claspin as an in vivo substrate for the BRCA1 E3 ligase and suggest that its modification selectively triggers CHK1 (show CHEK1 ELISA Kits) activation for the homology-directed repair of a subset of genotoxic lesions
analysis of claspin expression could be clinically relevant in the diagnosis of HPV-related cervical lesions, in particular when applied to cervico-vaginal cytology
The conserved C terminus of Claspin interacts with Rad9 and ensures timely activation of the ATR (show ANTXR1 ELISA Kits)-Chk1 (show CHEK1 ELISA Kits) pathway.
Tethering DNA damage checkpoint mediator proteins topoisomerase IIbeta-binding protein 1 (TopBP1) and Claspin to DNA activates ataxia-telangiectasia mutated and RAD3-related (ATR) phosphorylation of checkpoint kinase 1 (Chk1 (show CHEK1 ELISA Kits)).
Rad9A-mediated Claspin localization is a vital step during checkpoint activation.
Claspin localizes to mitotic centromeres depending on mitotic SUMOylation.
Claspin is phosphorylated at the midblastula transition at both DNA replication checkpoint-dependent and -independent sites.
recent findings and mechanisms of checkpoint regulation by claspin
the interaction of DDK with Claspin mediates a checkpoint-independent function of Claspin related to DNA replication.
Claspin has roles in the Chk1 (show CHEK1 ELISA Kits) pathway and functions in checkpoint control [review]
our findings suggest that only transient interaction of Claspin with replication forks potentiates its Chk1 (show CHEK1 ELISA Kits)-activating function. Also, stable binding of Claspin to chromatin may play a role in other functions besides the activation of Chk1 (show CHEK1 ELISA Kits).
The product of this gene is an essential upstream regulator of checkpoint kinase 1 and triggers a checkpoint arrest of the cell cycle in response to replicative stress or DNA damage. The protein is also required for efficient DNA replication during a normal S phase. Multiple transcript variants encoding different isoforms have been found for this gene.
claspin homolog (Xenopus laevis)
, claspin homolog