Coagulation Factor IX Proteins (F9)

F9 encodes vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. Additionally we are shipping Coagulation Factor IX Antibodies (290) and Coagulation Factor IX Kits (71) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
F9 2158 P00740
F9 14071 P16294
F9 24946 P16296
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Top Coagulation Factor IX Proteins at antibodies-online.com

Showing 10 out of 39 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Human Cells Human His tag 50 μg Log in to see 14 to 16 Days
$382.80
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,749.58
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,749.58
Details
Human Cells Mouse His tag 10 μg Log in to see 14 to 16 Days
$206.80
Details
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 18 Days
$576.00
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Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 15 to 18 Days
$736.00
Details
Escherichia coli (E. coli) Rat His tag 100 μg Log in to see 15 to 18 Days
$749.00
Details
Escherichia coli (E. coli) Rabbit His tag,GST tag 100 μg Log in to see 15 to 18 Days
$781.00
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Human Cells Human His tag   50 μg Log in to see 4 Days
$354.26
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$325.44
Details

F9 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
,
Mouse (Murine) , , ,

Rat (Rattus) , ,

Top referenced Coagulation Factor IX Proteins

  1. Human Coagulation Factor IX Protein expressed in Human Cells - ABIN2004307 : Espinós, Casaña, Haya, Cid, Aznar: Molecular analyses in hemophilia B families: identification of six new mutations in the factor IX gene. in Haematologica 2003 (PubMed)
    Show all 5 Pubmed References

More Proteins for Coagulation Factor IX (F9) Interaction Partners

Human Coagulation Factor IX (F9) interaction partners

  1. F8 and F9 gene variants result from a founder effect in two large French haemophilia cohorts

  2. available to predict the inhibitory activity on FIXa. On the basis of pharmacophore modeling, molecular docking, and 3D-QSAR modeling screening, six molecules are

  3. Report induced pluripotent stem cell model characterizing mutated F9 mRNA in hemophilia B.

  4. genetic association studies in cohort of patients in Switzerland: Data suggest that F9 propeptide mutation-associated hypersensitivity to vitamin K antagonist anticoagulants is rare phenomenon; F9 propeptide mutation Ala37Thr confers high sensitivity to warfarin.

  5. Higher FIX antigen levels are associated with incident coronary heart disease in blacks but not in whites; the association of FXI levels with ischemic stroke is slightly attenuated after adjusting for stroke risk factors.

  6. Report a diagnostic algorithm that can reliably identify pathogenic variants of factor 8/9 and von Willebrand factor and diagnose patients with hemophilia A, hemophilia B or von Willebrand disease.

  7. a computational approach was conducted to select suitable location(s) for introducing new N-glycosylation sites into the human coagulation factor IX.

  8. The pathogenic basis for one synonymous mutation (Val107Val) in the F9 gene associated with haemophilia B was determined.

  9. caspase-3 inhibitors also suppressed the attenuation of cell adhesion and phosphorylation of p38 MAPK by EGF-F9. Our data indicated that EGF-F9 activated signals for apoptosis and induced de-adhesion in a caspase-3 dependent manner.

  10. Specific factor IX mRNA and protein features that favor drug-induced readthrough over recurrent nonsense mutations have been reported.

  11. Here we optimize the transient transfection of HEK293T/17 cells for the production of AAV human factor IX in a disposable fixed-bed bioreactor, the iCELLis((R)) Nano (PALL Corporation).

  12. Our results confirm the rare event of Haemophilia A and haemophilia B in the same patient originating from two distinct genetic defects in F8 and F9 genes.

  13. Thus, splicing and protein alterations contribute to define at the molecular level the disease-causing effect of a number of exonic mutations in coagulation FIX exon 5. In addition, our results have a significant impact in the development of splicing-switching therapies in particular for mutations that affect both splicing and protein function

  14. This study confirms the high heterogeneity of molecular defects leading to hemophilia B in Belgium. Six missense variants and 1 in-frame deletion, previously unreported, were predicted to affect FIX protein function.

  15. this study shows that targeted high-throughput sequencing is an effective technique to detect the F9 gene mutations in hemophilia patients

  16. Patient 1 had a 149-kb deletion with breakpoints 90-kb upstream and 30-kb downstream from F9. Patients 2 and 3 showed 273-kb and 1.19-Mb deletions respectively. Patient 4 had two deleted regions: a 1663-bp deletion 1.34-Mb upstream from F9 and a 7.2-Mb deletion including F9.

  17. Factor IX mutation was found in every family: eight had large deletions, three had small deletions (<10 base pair) and 102 had single base pair substitutions (69 missense, 26 nonsense, four splice site and three promoter).

  18. Data suggest that coagulation factor IX (hFIX) minigene containing beta-globin (hBG) introns could represent a particular interest in stem cell-based gene therapy of hemophilias.

  19. miR-128 and miR-125 could help to increase the nonsense-mutant F9 levels by repressing nonsense-mediated mRNA decay.

  20. In 293T cells, the addition of 0.5 mM Ca(+2) and 1 mM Mg(+2) resulted in higher recombinant human Factor IX concentration. SK-Hep-1 cell line proved to be very effective in rhFIX production, and it can be used as a novel biotechnological platform for the production of recombinant proteins.

Mouse (Murine) Coagulation Factor IX (F9) interaction partners

  1. Authors investigated the interaction of coagulation factor IX in the development of atherosclerosis. Severe deficiency of FIX did not protect the animals from the development of atherosclerotic plaques in the aortic areas.

  2. activation peptide of factor IX regulates endothelial intercellular adhesion and thus could be used in the treatment of vascular hyperpermeability.

  3. structural features within residues of the 39-loop contribute to the resistance of FIXa to inhibition by plasma inhibitors ZPI and TFPI.

  4. Data indicate that the hyperactivating factor IX (FIX)-R338L mutation resulted in a robust 15-fold gain in potency and therefore provides a promising strategy to improve the efficacy, feasibility, and safety of hemophilia gene therapy.

  5. hnRNP A3 is a major liver nuclear protein binding to age related increase element of the factor IX gene.

  6. functional role of binding of F9 to collagen IV in hemostasis.

  7. FIX and FXI deficiency cause similar effects in the carotid artery injury model

  8. findings show coagulation factor IX & complement component C4-binding protein can bind Adenovirus fiber knob domain & provide a bridge for virus uptake through cell surface heparan sulfate proteoglycans & low-density lipoprotein receptor-related protein

  9. Mice lacking plasminogen and fIX (Plg(-/-)/fIX-/-) have lower mortality at age 6 months than Plg(-/-)/fIX+/+ mice

  10. activation of factor IX plays a more important role than that of TF/FVIIa complex activation of factor X in the early hemostatic response to vascular injury.

  11. important role for Lyn in VWF/GPIb-IX-induced integrin activation mediated via the cGMP signaling pathway independently of TXA2 synthesis and also indicate that Lyn is critically important in GPIb-IX-mediated activation of the cGMP pathway

  12. the heparin-binding exosite of factor IXa is a critical regulator of plasma thrombin generation and venous thrombosis

  13. Extravascular factor activity and joint-directed gene transfer may ameliorate hemophilic joint destruction, even in the absence of circulating FIX.

  14. new opportunities to observe genotype-phenotype and structure-function correlations regarding FIX, as well as the interaction of FIX with inflammatory, immune, and tissue repair systems

  15. age-related homeostasis mechanism is essential for spontaneous amelioration of hemophilia B Leyden

Cow (Bovine) Coagulation Factor IX (F9) interaction partners

  1. structural features within residues of the 39-loop contribute to the resistance of FIXa to inhibition by plasma inhibitors ZPI and TFPI.

  2. Mg2+ ions are required to maintain native conformation and in vivo function of factor IX gamma-carboxyglutamic acid domain

Coagulation Factor IX (F9) Protein Profile

Protein Summary

This gene encodes vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions, membrane phospholipids, and factor VIII. Alterations of this gene, including point mutations, insertions and deletions, cause factor IX deficiency, which is a recessive X-linked disorder, also called hemophilia B or Christmas disease.

Gene names and symbols associated with Coagulation Factor IX Proteins (F9)

  • coagulation factor IXa (f9a)
  • coagulation factor 9 (f9)
  • coagulation factor IX (CpipJ_CPIJ003776)
  • coagulation factor IX (CpipJ_CPIJ009129)
  • coagulation factor IX (CpipJ_CPIJ013063)
  • coagulation factor IX (CpipJ_CPIJ013624)
  • coagulation factor IX (Tsp_01441)
  • coagulation factor 9 S homeolog (f9.S)
  • Coagulation factor IX (fa9)
  • coagulation factor IX (F9)
  • AW111646 protein
  • Cf-9 protein
  • Cf9 protein
  • f9 protein
  • FIX protein
  • FIXA protein
  • HEMB protein
  • P19 protein
  • PTC protein
  • THPH8 protein
  • zgc:109775 protein

Protein level used designations for Coagulation Factor IX Proteins (F9)

coagulation factor IX , coagulation factor 9 (plasma thromboplastic component, Christmas disease, hemophilia B) , gla domain , coagulation factor 9 , Coagulation factor IX , coagulation factor IX-like , Christmas factor , F9 p22 , FIX F9 , factor 9 , factor IX F9 , plasma thromboplastic component , plasma thromboplastin component , christmas factor , Coagulation factor IX (plasma thromboplastic component, Christmas disease, hemophilia B) , coagulation factor IX (plasma thromboplastic component, Christmas disease, hemophilia B) , factor IX activated protein , factor IX

GENE ID SPECIES
359826 Danio rerio
496659 Xenopus (Silurana) tropicalis
6035113 Culex quinquefasciatus
6041549 Culex quinquefasciatus
6046266 Culex quinquefasciatus
6047200 Culex quinquefasciatus
10911295 Trichinella spiralis
100049721 Xenopus laevis
100380442 Salmo salar
100398468 Callithrix jacchus
2158 Homo sapiens
14071 Mus musculus
24946 Rattus norvegicus
280688 Bos taurus
100009113 Oryctolagus cuniculus
100135464 Cavia porcellus
397518 Sus scrofa
493973 Felis catus
374258 Gallus gallus
404015 Canis lupus familiaris
443316 Ovis aries
465887 Pan troglodytes
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